Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

Regulatory T cell (Treg)-mediated immunosuppression is considered a major obstacle for successful cancer immunotherapy. The association between clinical outcome and Tregs is being studied extensively in clinical trials, but unfortunately, no consensus has been reached about (a) the markers and (b) t...

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Bibliographic Details
Published in:	Cancer Immunology, Immunotherapy Vol. 64; no. 10; pp. 1271 - 1286
Main Authors:	Santegoets, Saskia J. A. M., Dijkgraaf, Eveline M., Battaglia, Alessandra, Beckhove, Philipp, Britten, Cedrik M., Gallimore, Awen, Godkin, Andrew, Gouttefangeas, Cecile, de Gruijl, Tanja D., Koenen, Hans J. P. M., Scheffold, Alexander, Shevach, Ethan M., Staats, Janet, Taskén, Kjetil, Whiteside, Theresa L., Kroep, Judith R., Welters, Marij J. P., van der Burg, Sjoerd H.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2015 Springer Nature B.V
Subjects:	Animals Antigens, CD - metabolism Biomarkers - metabolism Cancer Cancer Research Cell Separation Cells, Cultured Clinical trials Consensus Cytokines Female Flow Cytometry Forkhead Transcription Factors - metabolism Humans Immunology Immunotherapy International Cooperation Ki-67 Antigen - metabolism Lymphocyte Activation Lymphocytes Medical prognosis Medical research Medicine Medicine & Public Health Monitoring, Immunologic Oncology Original Original Article Ovarian Neoplasms - immunology Reference Standards T-Lymphocytes, Regulatory - immunology Tumor Escape Netherlands United Kingdom > UK United States > US Germany Flow cytometry Tregs Consensus Monitoring Phenotyping
ISSN:	0340-7004, 1432-0851
Online Access:	Get full text
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