Ultrahigh-Speed Swept-Source OCT Angiography in Exudative AMD

BACKGROUND AND OBJECTIVE:To investigate the potential of ultrahigh-speed swept-source optical coherence tomography angiography (OCTA) to visualize retinal and choroidal vascular changes in patients with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS:Observational, prospective...

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Published in:Ophthalmic surgery, lasers & imaging Vol. 45; no. 6; pp. 496 - 505
Main Authors: Moult, Eric, Choi, WooJhon, Waheed, Nadia K., Adhi, Mehreen, Lee, ByungKun, Lu, Chen D., Jayaraman, Vijaysekhar, Potsaid, Benjamin, Rosenfeld, Philip J., Duker, Jay S., Fujimoto, James G.
Format: Journal Article
Language:English
Published: Thorofare, NJ SLACK Incorporated 01.11.2014
SLACK INCORPORATED
Subjects:
Adult
Age related diseases
Aged
Aged, 80 and over
Angiography
Choroid - blood supply
Choroidal Neovascularization - diagnosis
Ciliary Arteries - diagnostic imaging
Ciliary Arteries - pathology
Cross-Sectional Studies
Exudates and Transudates
Exudation
Eye diseases
Eyes & eyesight
Female
Flow velocity
Humans
Macular degeneration
Male
Medical diagnosis
Medical imaging
Middle Aged
Monitoring
Patients
Prospective Studies
Retinal Vessels - diagnostic imaging
Retinal Vessels - pathology
Tomography, Optical Coherence
Vascular endothelial growth factor
Visualization
Wet Macular Degeneration - diagnosis
Young Adult
ISSN:2325-8160, 2325-8179, 2325-8179
Online Access:Get full text
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Summary:BACKGROUND AND OBJECTIVE:To investigate the potential of ultrahigh-speed swept-source optical coherence tomography angiography (OCTA) to visualize retinal and choroidal vascular changes in patients with exudative age-related macular degeneration (AMD). PATIENTS AND METHODS:Observational, prospective cross-sectional study. An ultrahigh-speed swept-source prototype was used to perform OCTA of the retinal and choriocapillaris microvasculature in 63 eyes of 32 healthy controls and 19 eyes of 15 patients with exudative AMD. Main outcome measure: qualitative comparison of the retinal and choriocapillaris microvasculature in the two groups. RESULTS:Choroidal neovascularization (CNV) was clearly visualized in 16 of the 19 eyes with exudative AMD, located above regions of severe choriocapillaris alteration. In 14 of these eyes, the CNV lesions were surrounded by regions of choriocapillaris alteration. CONCLUSION:OCTA may offer noninvasive monitoring of the retinal and choriocapillaris microvasculature in patients with CNV, which may assist in diagnosis and monitoring.[Ophthalmic Surg Lasers Imaging Retina. 2014;45:496–505.]
Bibliography:SourceType-Scholarly Journals-1
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Dr. Duker did not participate in the editorial review of this manuscript. Mr. Moult and Dr. Choi contributed equally to this manuscript.
ISSN:2325-8160
2325-8179
2325-8179
DOI:10.3928/23258160-20141118-03