Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

There has been a steep increase in allergic and autoimmune diseases, reaching epidemic proportions and now affecting more than one billion people worldwide. These diseases are more common in industrialized countries, and their prevalence continues to rise in developing countries in parallel to urban...

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Bibliographic Details
Published in:	Nature reviews. Immunology Vol. 21; no. 11; pp. 739 - 751
Main Author:	Akdis, Cezmi A
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.11.2021
Subjects:	Allergens Allergic rhinitis Allergies Alzheimer's disease Animals Ankylosing spondylitis Asthma Atopic dermatitis Autism Autoimmune diseases Autoimmune Diseases - epidemiology Autoimmunity Celiac disease Chronic Disease - epidemiology Chronic illnesses Dermatitis Dermatitis, Atopic - epidemiology Developing countries Diabetes mellitus Disease Epithelium Esophagitis Hepatitis Humans Hypersensitivity - epidemiology Hypotheses Immune response Industrial development Industrialization Inflammatory bowel diseases LDCs Leukocytes (eosinophilic) Metabolism Movement disorders Mucosa Multiple sclerosis Neurodegenerative diseases Parkinson's disease Pollutants Rheumatoid arthritis Rhinitis Rhinitis, Allergic - epidemiology Toxins Urbanization
ISSN:	1474-1733, 1474-1741, 1474-1741
Online Access:	Get full text
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