Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial

Panobinostat is a potent oral pan-deacetylase inhibitor that in preclinical studies has synergistic anti-myeloma activity when combined with bortezomib and dexamethasone. We aimed to compare panobinostat, bortezomib, and dexamethasone with placebo, bortezomib, and dexamethasone in patients with rela...

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Vydáno v:	The lancet oncology Ročník 15; číslo 11; s. 1195 - 1206
Hlavní autoři:	San-Miguel, Jesús F, Hungria, Vânia T M, Yoon, Sung-Soo, Beksac, Meral, Dimopoulos, Meletios Athanasios, Elghandour, Ashraf, Jedrzejczak, Wieslaw Wiktor, Günther, Andreas, Nakorn, Thanyaphong Na, Siritanaratkul, Noppadol, Corradini, Paolo, Chuncharunee, Suporn, Lee, Je-Jung, Schlossman, Robert L, Shelekhova, Tatiana, Yong, Kwee, Tan, Daryl, Numbenjapon, Tontanai, Cavenagh, Jamie D, Hou, Jian, LeBlanc, Richard, Nahi, Hareth, Qiu, Lugui, Salwender, Hans, Pulini, Stefano, Moreau, Philippe, Warzocha, Krzysztof, White, Darrell, Bladé, Joan, Chen, WenMing, de la Rubia, Javier, Gimsing, Peter, Lonial, Sagar, Kaufman, Jonathan L, Ocio, Enrique M, Veskovski, Ljupco, Sohn, Sang Kyun, Wang, Ming-Chung, Lee, Jae Hoon, Einsele, Hermann, Sopala, Monika, Corrado, Claudia, Bengoudifa, Bourras-Rezki, Binlich, Florence, Richardson, Paul G
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.10.2014 Elsevier Limited
Témata:	Administration, Oral Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Boronic Acids - administration & dosage Bortezomib Dexamethasone - administration & dosage Disease-Free Survival Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Drug dosages Drug therapy Female Heart attacks Hematology, Oncology and Palliative Medicine Humans Hydroxamic Acids - administration & dosage Indoles - administration & dosage Infusions, Intravenous Kaplan-Meier Estimate Male Maximum Tolerated Dose Middle Aged Multiple Myeloma - drug therapy Multiple Myeloma - mortality Multiple Myeloma - pathology Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Patients Prognosis Pyrazines - administration & dosage Remission Induction Survival Analysis Transplants & implants Treatment Outcome
ISSN:	1470-2045, 1474-5488, 1474-5488
On-line přístup:	Získat plný text
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