Engineered T cells for cancer therapy

It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline o...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Vol. 63; no. 9; pp. 969 - 975
Main Authors: June, Carl H., Maus, Marcela V., Plesa, Gabriela, Johnson, Laura A., Zhao, Yangbing, Levine, Bruce L., Grupp, Stephan A., Porter, David L.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2014
Springer Nature B.V
Subjects:
Animals
Antigens
Cancer Research
Cancer therapies
Clinical trials
Focussed Research Review
Genes
Genetic engineering
Genetic Engineering - methods
HIV
Human immunodeficiency virus
Humans
Immunology
Immunotherapy
Immunotherapy, Adoptive - methods
Lymphocytes
Medicine
Medicine & Public Health
Melanoma
Multiple myeloma
Oncology
Receptors, Antigen, T-Cell - genetics
Synthetic biology
T cell receptors
T-Lymphocytes - immunology
Toxicity
United States > US
Gene transfer
Chimeric antigen receptor
Adoptive cell transfer
Leukemia
19th Danish Cancer Society Symposium
ISSN:0340-7004, 1432-0851, 1432-0851
Online Access:Get full text
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Summary:It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this focused research review.
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ISSN:0340-7004
1432-0851
1432-0851
DOI:10.1007/s00262-014-1568-1