Electrospun Polyvinylpyrrolidone-Based Dressings Containing GO/ZnO Nanocomposites: A Novel Frontier in Antibacterial Wound Care

In recent years, the rapid emergence of antibiotic-resistant bacteria has become a significant concern in the healthcare field, and although bactericidal dressings loaded with various classes of antibiotics have been used in clinics, in addition to other anti-infective strategies, this alarming issu...

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Bibliographic Details
Published in:Pharmaceutics Vol. 16; no. 3; p. 305
Main Authors: Martín, Cristina, Ferreiro Fernández, Adalyz, Salazar Romero, Julia C., Fernández-Blázquez, Juan P., Mendizabal, Jabier, Artola, Koldo, Jorcano, José L., Rabanal, M. Eugenia
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 22.02.2024
MDPI
Subjects:
antibacterial
Antibacterial agents
Antibiotics
Bacterial infections
Care and treatment
dressings
Drug resistance
E coli
Electron microscopes
electrospinning
Escherichia coli
Graphene
graphene oxide
Health aspects
Nanocomposites
Nanomaterials
Nanoparticles
Povidone
Silver
Tetracycline
Tetracyclines
Wound healing
Wounds and injuries
Zinc oxide
Zinc oxides
ZnO
Spain
United States > US
dressings
graphene oxide
ZnO
antibacterial
electrospinning
ISSN:1999-4923, 1999-4923
Online Access:Get full text
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Summary:In recent years, the rapid emergence of antibiotic-resistant bacteria has become a significant concern in the healthcare field, and although bactericidal dressings loaded with various classes of antibiotics have been used in clinics, in addition to other anti-infective strategies, this alarming issue necessitates the development of innovative strategies to combat bacterial infections and promote wound healing. Electrospinning technology has gained significant attention as a versatile method for fabricating advanced wound dressings with enhanced functionalities. This work is based on the generation of polyvinylpyrrolidone (PVP)-based dressings through electrospinning, using a DomoBIO4A bioprinter, and incorporating graphene oxide (GO)/zinc oxide (ZnO) nanocomposites as a potent antibacterial agent. GO and ZnO nanoparticles offer unique properties, including broad-spectrum antibacterial activity for improved wound healing capabilities. The synthesis process was performed in an inexpensive one-pot reaction, and the nanocomposites were thoroughly characterized using XRD, TEM, EDX, SEM, EDS, and TGA. The antibacterial activity of the dispersions was demonstrated against E. coli and B. subtilis, Gram-negative and Gram-positive bacteria, respectively, using the well diffusion method and the spread plate method. Bactericidal mats were synthesized in a rapid and cost-effective manner, and the fiber-based structure of the electrospun dressings was studied by SEM. Evaluations of their antibacterial efficacy against E. coli and B. subtilis were explored by the disk-diffusion method, revealing an outstanding antibacterial capacity, especially against the Gram-positive strain. Overall, the findings of this research contribute to the development of next-generation wound dressings that effectively combat bacterial infections and pave the way for advanced therapeutic interventions in the field of wound care.
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16030305