Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone

Methotrexate (MTX) is a drug used in treatment of various malignancies. Unfortunately, it leads to life-threatening complications including hepatorenal toxicity. Previous studies revealed the protective effects of metformin (MET) on hepatorenal toxicity in other models in addition to its anticancer...

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Veröffentlicht in:	Journal of inflammation research Jg. 11; S. 421 - 429
Hauptverfasser:	Rizk, Fatma H., El Saadany, Amira A., Dawood, Lamees, Elkaliny, Heba H., Sarhan, Naglaa I., Badawi, Rehab, Abd-Elsalam, Sherief
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New Zealand Dove Medical Press Limited 01.01.2018 Taylor & Francis Ltd Dove Medical Press
Schlagworte:	Antidiabetics Antineoplastic agents Antioxidants Antioxidants (Nutrients) Apoptosis Arthritis ATPases B cells Biochemistry Cancer therapies Cancer treatment Chemotherapy Complications and side effects COX-2 inhibitors Cytotoxicity Drug dosages EDTA Enzymes Experiments Hepatorenal toxicity Immunomodulators Kidneys Kinases Laboratory animals Liver Medical research Medicine Messenger RNA Metformin Methotrexate Mitochondria Original Research Oxidative stress Proteins RNA Toxicity Type 2 diabetes United States > US Egypt hepatorenal toxicity metformin methotrexate
ISSN:	1178-7031, 1178-7031
Online-Zugang:	Volltext
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