Secretion of Angiogenic Growth Factors by Villous Cytotrophoblast and Extravillous Trophoblast in Early Human Pregnancy

Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth fact...

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Veröffentlicht in:	Placenta (Eastbourne) Jg. 31; H. 6; S. 545 - 548
Hauptverfasser:	Lash, G.E., Naruse, K., Innes, B.A., Robson, S.C., Searle, R.F., Bulmer, J.N.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Kidlington Elsevier Ltd 01.06.2010 Elsevier
Schlagworte:	Angiogenesis Angiogenic Proteins - secretion Biological and medical sciences Cells, Cultured Chorionic Villi - secretion Embryology: invertebrates and vertebrates. Teratology Enzyme-Linked Immunosorbent Assay Extravillous trophoblast Female First trimester pregnancy Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Internal Medicine Neovascularization, Physiologic - physiology Obstetrics and Gynecology Placentation - physiology Pregnancy Pregnancy Trimester, First - physiology Trophoblasts - cytology Trophoblasts - secretion Villous cytotrophoblast First trimester pregnancy Villous cytotrophoblast Angiogenesis Extravillous trophoblast Human Trophoblaste Vertebrata Mammalia Angiogenic factor Cytotrophoblast Fetal membrane Secretion Early pregnancy Growth factor
ISSN:	0143-4004, 1532-3102, 1532-3102
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Abstract	Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8–10 and 12–14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling.
AbstractList	AbstractAngiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8–10 and 12–14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling. Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8-10 and 12-14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling.Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8-10 and 12-14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling. Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8-10 and 12-14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling.
Author	Naruse, K. Bulmer, J.N. Lash, G.E. Innes, B.A. Robson, S.C. Searle, R.F.
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Keywords	First trimester pregnancy Villous cytotrophoblast Angiogenesis Extravillous trophoblast Human Trophoblaste Vertebrata Mammalia Angiogenic factor Cytotrophoblast Fetal membrane Secretion Early pregnancy Growth factor
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Snippet	Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth... AbstractAngiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth...
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SubjectTerms	Angiogenesis Angiogenic Proteins - secretion Biological and medical sciences Cells, Cultured Chorionic Villi - secretion Embryology: invertebrates and vertebrates. Teratology Enzyme-Linked Immunosorbent Assay Extravillous trophoblast Female First trimester pregnancy Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Internal Medicine Neovascularization, Physiologic - physiology Obstetrics and Gynecology Placentation - physiology Pregnancy Pregnancy Trimester, First - physiology Trophoblasts - cytology Trophoblasts - secretion Villous cytotrophoblast
Title	Secretion of Angiogenic Growth Factors by Villous Cytotrophoblast and Extravillous Trophoblast in Early Human Pregnancy
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