Secretion of Angiogenic Growth Factors by Villous Cytotrophoblast and Extravillous Trophoblast in Early Human Pregnancy

Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth fact...

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Veröffentlicht in:Placenta (Eastbourne) Jg. 31; H. 6; S. 545 - 548
Hauptverfasser: Lash, G.E., Naruse, K., Innes, B.A., Robson, S.C., Searle, R.F., Bulmer, J.N.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Kidlington Elsevier Ltd 01.06.2010
Elsevier
Schlagworte:
Angiogenesis
Angiogenic Proteins - secretion
Biological and medical sciences
Cells, Cultured
Chorionic Villi - secretion
Embryology: invertebrates and vertebrates. Teratology
Enzyme-Linked Immunosorbent Assay
Extravillous trophoblast
Female
First trimester pregnancy
Fundamental and applied biological sciences. Psychology
Humans
Immunohistochemistry
Internal Medicine
Neovascularization, Physiologic - physiology
Obstetrics and Gynecology
Placentation - physiology
Pregnancy
Pregnancy Trimester, First - physiology
Trophoblasts - cytology
Trophoblasts - secretion
Villous cytotrophoblast
First trimester pregnancy
Villous cytotrophoblast
Angiogenesis
Extravillous trophoblast
Human
Trophoblaste
Vertebrata
Mammalia
Angiogenic factor
Cytotrophoblast
Fetal membrane
Secretion
Early pregnancy
Growth factor
ISSN:0143-4004, 1532-3102, 1532-3102
Online-Zugang:Volltext
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Zusammenfassung:Angiogenesis is a key feature of placental and uterine development in early pregnancy. We hypothesized that trophoblast cells produce angiogenic growth factors, and that expression differs between villous cytotrophoblast (CTB) and extravillous trophoblast (EVT) cells. Fourteen angiogenic growth factors were measured by multiplex growth factor analysis or ELISA in tissue culture supernatants from EVT and CTB from pregnancies at 8–10 and 12–14 weeks' gestation. Gestational age and cell type differences were observed. EVT and CTB are major producers of angiogenic growth factors that likely contribute to placental vascular development and spiral artery remodeling.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2010.02.020