Distributed coding of choice, action and engagement across the mouse brain

Vision, choice, action and behavioural engagement arise from neuronal activity that may be distributed across brain regions. Here we delineate the spatial distribution of neurons underlying these processes. We used Neuropixels probes 1 , 2 to record from approximately 30,000 neurons in 42 brain regi...

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Vydané v:	Nature (London) Ročník 576; číslo 7786; s. 266 - 273
Hlavní autori:	Steinmetz, Nicholas A., Zatka-Haas, Peter, Carandini, Matteo, Harris, Kenneth D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 12.12.2019 Nature Publishing Group
Predmet:	631/378/2629/1409 631/378/3920 Animals Basal ganglia Brain Brain - physiology Brain Mapping Cerebral cortex Choice Behavior Female Forebrain Ganglia Humanities and Social Sciences Male Mesencephalon Mice multidisciplinary Neocortex Neural coding Neurons Potassium channels Reward Science Science (multidisciplinary) Spatial distribution Task Performance and Analysis Visual discrimination Visual Perception Visual stimuli Visual tasks
ISSN:	0028-0836, 1476-4687, 1476-4687
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Shrnutí:	Vision, choice, action and behavioural engagement arise from neuronal activity that may be distributed across brain regions. Here we delineate the spatial distribution of neurons underlying these processes. We used Neuropixels probes 1 , 2 to record from approximately 30,000 neurons in 42 brain regions of mice performing a visual discrimination task 3 . Neurons in nearly all regions responded non-specifically when the mouse initiated an action. By contrast, neurons encoding visual stimuli and upcoming choices occupied restricted regions in the neocortex, basal ganglia and midbrain. Choice signals were rare and emerged with indistinguishable timing across regions. Midbrain neurons were activated before contralateral choices and were suppressed before ipsilateral choices, whereas forebrain neurons could prefer either side. Brain-wide pre-stimulus activity predicted engagement in individual trials and in the overall task, with enhanced subcortical but suppressed neocortical activity during engagement. These results reveal organizing principles for the distribution of neurons encoding behaviourally relevant variables across the mouse brain. Recordings from 30,000 neurons in 42 brain regions are used to delineate the spatial distribution of neuronal activity underlying vision, choice, action and behavioural engagement in mice.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Present address: Department of Biological Structure, University of Washington, Seattle, WA. These authors jointly supervised this work: Matteo Carandini, Kenneth D. Harris
ISSN:	0028-0836 1476-4687 1476-4687
DOI:	10.1038/s41586-019-1787-x