Coxsackievirus A24 causing acute conjunctivitis in a 2023 outbreak in Vietnam

•RNA-sequence analysis can identify causes of conjunctivitis outbreaks.•Coxsackievirus A24 was likely responsible for a conjunctivitis epidemic in Asia in 2023.•Purulence and itching can be seen commonly with viral eye infections.•Phylogenic analysis links this coxsackie virus to similar outbreaks w...

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Vydané v:	International journal of infectious diseases Ročník 146; s. 107133
Hlavní autori:	Tran, Huy, Ha, Thao, Hoang, Linh, Tran, Yen, Ruder, Kevin, Liu, YuHeng, Yu, Danny, Abraham, Thomas, Hinterwirth, Armin, Deiner, Michael, Porco, Travis C., Lietman, Thomas M., Doan, Thuy, Seitzman, Gerami D., Prajna, Lalitha, Prajna, N. Venkatesh, Gunasekaran, Ramesh, Sharma, Sankalp Singh, Teja, Vishnu, Chaudhary, Meenu, Sitaula, Sanjeeta, Sié, Ali, Coulibaly, Boubacar, Bountogo, Mamadou, Satitpitakul, Vannarut, Mai, Linh Hoàng, Xuân, Thảo Hạ, Urzua, Cristhian A., Vega, Fabian, Cuitino, Loreto, Pérez, Fernando Pérez, Martínez, Jaime Macías, Lansingh, Van Charles, Thanapaisal, Sukhumal, Laovirojjanakul, Wipada, McKie, George, Chavez, Kenia, Redd, Travis, Chamberlain, Winston, Cheng, Angel, Sansanayudh, Wiwan, Yakoura, Abba Kaka Hajia, Amza, Abdou, Souley, Abdoul Salam Youssoufou, Diori, Adam Nouhou, Nassirou, Beido, Kadri, Boubacar, Mariama, Boubacar, Ibrahim, Cissé Mamadou, Roufaye, Lamyne Aboubacar, Boulhassane, Ramatou, Ali, Saley, Abdou, Zakou, Goren, Lee, Bahar, Irit, Sella, Ruti, Ong, Hon Shing, Mehta, Jod, Liu, Yu-Chi, Hwang, De-Kuang, Fan, Nai-Wen, Chiong, Hong Sheng, Cabrera-Aguas, Maria, Watson, Stephanie, Cherian, Nina M., Feit-Leichman, Rachel, Hughes, Reginald E., Onclinx, Tania, McClean, Esmeralda, Molina, Iliana, Chen, Cindi, Liu, David, Lebas, Elodie, Colby, Emily, Seitzman, Gerami, Lietman, Thomas, McLeod, Stephen, Kanai, Kuniyoshi, Whiteside, Meredith, Yeh, Steven, Fashina, Tolulope, Chodosh, James, Tarkap, Bridgit, Garap, Jambi N., Mangot, Magdalene, Amel, Edwin, Taleo, Fasihah, Kasso, Johnson, Willie, Kalbule, Nanu, Madopule, Rymill, Prudence, Solomon, Anthony W.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Canada Elsevier Ltd 01.09.2024 Elsevier
Predmet:	Adolescent Adult Child Child, Preschool Conjunctivitis Conjunctivitis, Acute Hemorrhagic - epidemiology Conjunctivitis, Acute Hemorrhagic - virology Conjunctivitis, Viral - epidemiology Conjunctivitis, Viral - virology Coxsackievirus Coxsackievirus Infections - epidemiology Coxsackievirus Infections - virology Disease Outbreaks Epidemic Female Humans Keratoconjunctivitis (EKC) Male Middle Aged Phylogeny Vietnam Vietnam - epidemiology Young Adult Vietnam Epidemic Coxsackievirus Vietnam Conjunctivitis Keratoconjunctivitis (EKC)
ISSN:	1201-9712, 1878-3511, 1878-3511
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Shrnutí:	•RNA-sequence analysis can identify causes of conjunctivitis outbreaks.•Coxsackievirus A24 was likely responsible for a conjunctivitis epidemic in Asia in 2023.•Purulence and itching can be seen commonly with viral eye infections.•Phylogenic analysis links this coxsackie virus to similar outbreaks worldwide. To determine the associated pathogen during the 2023 conjunctivitis outbreak in Vietnam RNA-sequencing was used to identify pathogens before and during the outbreak. 24 patients with infectious conjunctivitis between March and October 2023 from Hai Yen Vision Institute in Vietnam were swabbed. Coxsackievirus A24v was the most common pathogen identified. Phylogenetic analysis of these strains demonstrates similarities to the Coxsackievirus identified in the 2022 India outbreak. Human adenovirus D was also circulating. Ocular findings of tearing, purulence, and itching were common in this outbreak. Multiple viruses can co-circulate during conjunctivitis outbreaks. Hemorrhagic conjunctivitis, commonly associated with coxsackievirus conjunctivitis, was not a common clinical sign in this outbreak. Repeat genetic surveillance, with the notable inclusion of RNA virus detection strategies, is important for outbreak detection.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 See Members of the SCORPIO Study Group in Appendix. Huy Tran: Study implementation, Data Collection, analysis and interpretation of data, contributed to writing, approved final manuscript. Thao Ha, Linh Hoang, and Yen Tran: Study implementation, Data Collection, read and approved final manuscript. Kevin Ruder, Lina Zhong, Cindi Chen, YuHeng Liu, Danny Yu, and Thomas Abraham: Study implementation, read approved final manuscript. Armin Hinterwirth, Michael Deiner, and Travis C. Porco: Study implementation, data analysis, read and approved final manuscript. Thomas M. Lietman: Study design, data analysis, approved final mansucript. Thuy Doan and Gerami D. Seitzman: Study design, Study implementation, data analysis, major contributing to writing, read and approved final manuscript. Author contributions
ISSN:	1201-9712 1878-3511 1878-3511
DOI:	10.1016/j.ijid.2024.107133