Roles of Marine Macroalgae or Seaweeds and Their Bioactive Compounds in Combating Overweight, Obesity and Diabetes: A Comprehensive Review

Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin res...

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Vydáno v:Marine drugs Ročník 21; číslo 4; s. 258
Hlavní autoři: Magwaza, S’thandiwe, Islam, Md
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 21.04.2023
MDPI
Témata:
Algae
Animals
Anti-Obesity Agents - pharmacology
Anti-Obesity Agents - therapeutic use
Bioactive compounds
Biological activity
Biological products
Body weight
Care and treatment
Carnitine
Chemical properties
Chronic illnesses
Clinical trials
Developing countries
diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
energy
Food and Drug Administration
Health aspects
In vivo methods and tests
Insulin
Insulin resistance
LDCs
macroalgae
Marine algae
marine macroalgae
noninsulin-dependent diabetes mellitus
Obesity
Obesity - drug therapy
Overweight - drug therapy
Review
Seaweed
Seaweeds
Side effects
Type 2 diabetes
South Africa
bioactive compounds
seaweeds
marine macroalgae
type 2 diabetes
diabetes
obesity
ISSN:1660-3397, 1660-3397
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Shrnutí:Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin resistance, suggesting a strong association with type 2 diabetes (T2D). The available therapies for these diseases have side effects and some still need to be approved by the Food and Drug Administration (FDA), and they are expensive for underdeveloped countries. Hence, the need for natural anti-obesity and anti-diabetic drugs has increased in recent years due to their lower costs and having virtually no or negligible side effects. This review thoroughly examined the anti-obesity and anti-diabetic effects of various marine macroalgae or seaweeds and their bioactive compounds in different experimental settings. According to the findings of this review, seaweeds and their bioactive compounds have been shown to have strong potential to alleviate obesity and diabetes in both in vitro and in vivo or animal-model studies. However, the number of clinical trials in this regard is limited. Hence, further studies investigating the effects of marine algal extracts and their bioactive compounds in clinical settings are required for developing anti-obesity and anti-diabetic medicines with better efficacy but lower or no side effects.
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ISSN:1660-3397
1660-3397
DOI:10.3390/md21040258