Roles of Marine Macroalgae or Seaweeds and Their Bioactive Compounds in Combating Overweight, Obesity and Diabetes: A Comprehensive Review
Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin res...
Saved in:
| Published in: | Marine drugs Vol. 21; no. 4; p. 258 |
|---|---|
| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Switzerland
MDPI AG
21.04.2023
MDPI |
| Subjects: | |
| ISSN: | 1660-3397, 1660-3397 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin resistance, suggesting a strong association with type 2 diabetes (T2D). The available therapies for these diseases have side effects and some still need to be approved by the Food and Drug Administration (FDA), and they are expensive for underdeveloped countries. Hence, the need for natural anti-obesity and anti-diabetic drugs has increased in recent years due to their lower costs and having virtually no or negligible side effects. This review thoroughly examined the anti-obesity and anti-diabetic effects of various marine macroalgae or seaweeds and their bioactive compounds in different experimental settings. According to the findings of this review, seaweeds and their bioactive compounds have been shown to have strong potential to alleviate obesity and diabetes in both in vitro and in vivo or animal-model studies. However, the number of clinical trials in this regard is limited. Hence, further studies investigating the effects of marine algal extracts and their bioactive compounds in clinical settings are required for developing anti-obesity and anti-diabetic medicines with better efficacy but lower or no side effects. |
|---|---|
| AbstractList | Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin resistance, suggesting a strong association with type 2 diabetes (T2D). The available therapies for these diseases have side effects and some still need to be approved by the Food and Drug Administration (FDA), and they are expensive for underdeveloped countries. Hence, the need for natural anti-obesity and anti-diabetic drugs has increased in recent years due to their lower costs and having virtually no or negligible side effects. This review thoroughly examined the anti-obesity and anti-diabetic effects of various marine macroalgae or seaweeds and their bioactive compounds in different experimental settings. According to the findings of this review, seaweeds and their bioactive compounds have been shown to have strong potential to alleviate obesity and diabetes in both in vitro and in vivo or animal-model studies. However, the number of clinical trials in this regard is limited. Hence, further studies investigating the effects of marine algal extracts and their bioactive compounds in clinical settings are required for developing anti-obesity and anti-diabetic medicines with better efficacy but lower or no side effects. Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin resistance, suggesting a strong association with type 2 diabetes (T2D). The available therapies for these diseases have side effects and some still need to be approved by the Food and Drug Administration (FDA), and they are expensive for underdeveloped countries. Hence, the need for natural anti-obesity and anti-diabetic drugs has increased in recent years due to their lower costs and having virtually no or negligible side effects. This review thoroughly examined the anti-obesity and anti-diabetic effects of various marine macroalgae or seaweeds and their bioactive compounds in different experimental settings. According to the findings of this review, seaweeds and their bioactive compounds have been shown to have strong potential to alleviate obesity and diabetes in both in vitro and in vivo or animal-model studies. However, the number of clinical trials in this regard is limited. Hence, further studies investigating the effects of marine algal extracts and their bioactive compounds in clinical settings are required for developing anti-obesity and anti-diabetic medicines with better efficacy but lower or no side effects.Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a severe metabolic problem that results in energy imbalance that is persistent over a long period of time, and it is characterized by insulin resistance, suggesting a strong association with type 2 diabetes (T2D). The available therapies for these diseases have side effects and some still need to be approved by the Food and Drug Administration (FDA), and they are expensive for underdeveloped countries. Hence, the need for natural anti-obesity and anti-diabetic drugs has increased in recent years due to their lower costs and having virtually no or negligible side effects. This review thoroughly examined the anti-obesity and anti-diabetic effects of various marine macroalgae or seaweeds and their bioactive compounds in different experimental settings. According to the findings of this review, seaweeds and their bioactive compounds have been shown to have strong potential to alleviate obesity and diabetes in both in vitro and in vivo or animal-model studies. However, the number of clinical trials in this regard is limited. Hence, further studies investigating the effects of marine algal extracts and their bioactive compounds in clinical settings are required for developing anti-obesity and anti-diabetic medicines with better efficacy but lower or no side effects. |
| Audience | Academic |
| Author | Magwaza, S’thandiwe Islam, Md |
| AuthorAffiliation | Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa |
| AuthorAffiliation_xml | – name: Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal (Westville Campus), Durban 4000, South Africa |
| Author_xml | – sequence: 1 givenname: S’thandiwe orcidid: 0000-0003-4885-6126 surname: Magwaza fullname: Magwaza, S’thandiwe – sequence: 2 givenname: Md orcidid: 0000-0003-0309-9491 surname: Islam fullname: Islam, Md |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37103396$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkl1v0zAYhSM0xD7ghh-AInGDEB3Oh2ObG1TK16ShSmNcW479JvWU2MVOW-0v8Kt5025snSahXDg-fs5R_OYcJwfOO0iSlxk5LQpB3vcmz0hJcsqfJEdZVZEJyuzg3vthchzjFSEF5aJ8lhwWLCOoV0fJnwvfQUx9k_5QwTrARQevulZB6kP6E9QGwMRUOZNeLsCG9JP1Sg92DenM90u_cnhq3bip1WBdm87XEDZg28XwLp3XEO1wvbV_tqqGAeKHdLq1BliAi2PQBawtbJ4nTxvVRXhxs54kv75-uZx9n5zPv53NpucTTVkxTDIlmOI8r0jFDKN1XRooal4ammnKmyLXeYVXq1DPM9XUigNtqKm50JyyRhUnydku13h1JZfB9ipcS6-s3Ao-tFKFweoOZM6UZqZiWSNUmVOG8USUWjCqiSlMhVkfd1nLVd2D0eCGoLq90P0TZxey9WuZkazMs7LEhDc3CcH_XkEcZG-jhq5TDvwqygL_bMEKzv-P5pxUQpQVE4i-foBe-VVwONYtRenYijuqVXhZ6xqP36jHUDlllCAiBEXq9BEKHwO91VjFxqK-Z3h1fyj_pnHbOgTIDsCqxRigkdoOWB4_zsh2OBw5FlveFRstbx9YblMfgf8CJDr2aQ |
| CitedBy_id | crossref_primary_10_1002_fsn3_70956 crossref_primary_10_3390_md22120528 crossref_primary_10_1002_biof_70027 crossref_primary_10_1111_1751_7915_70058 crossref_primary_10_1016_j_intimp_2025_114844 crossref_primary_10_1016_j_algal_2025_104048 crossref_primary_10_3389_fmars_2024_1438955 crossref_primary_10_3390_antiox12091743 crossref_primary_10_3390_md22050210 crossref_primary_10_1016_j_fbio_2025_107371 crossref_primary_10_3390_biology13110904 crossref_primary_10_1016_j_sciaf_2023_e02051 crossref_primary_10_3390_life13091831 crossref_primary_10_4490_algae_2025_40_4_24 crossref_primary_10_1016_j_ecoenv_2025_119034 crossref_primary_10_1016_j_aquaculture_2024_742035 crossref_primary_10_3390_phycology5020025 crossref_primary_10_1177_1934578X251350769 crossref_primary_10_1016_j_biortech_2025_132424 crossref_primary_10_1016_j_fitote_2024_106252 |
| Cites_doi | 10.1016/j.procbio.2010.05.016 10.1007/s10068-014-0125-1 10.1002/lipd.12002 10.1161/CIRCULATIONAHA.111.039453 10.3389/fphar.2020.00831 10.1007/s13765-012-2108-3 10.1111/j.1559-4572.2008.00044.x 10.3390/md14080148 10.1186/1476-511X-11-112 10.1001/jama.2016.7602 10.1007/s00125-017-4318-z 10.1016/j.lfs.2006.04.022 10.3746/pnf.2012.17.1.001 10.1039/b600518g 10.3390/md17110612 10.1080/16549716.2022.2045092 10.3390/md13084799 10.1210/jc.2004-0395 10.3390/medicina56120634 10.1016/j.jff.2014.10.015 10.1007/s00210-020-01861-x 10.3390/md17050272 10.1016/j.jfda.2015.06.003 10.1016/j.fitote.2012.04.027 10.1016/j.jff.2018.07.045 10.3390/md10030604 10.1155/2018/9354296 10.1016/j.etap.2013.10.011 10.1007/s10811-011-9679-y 10.1002/jsfa.5585 10.3390/cells9040871 10.1007/s12010-012-9602-2 10.1016/j.foodhyd.2009.10.007 10.1002/ptr.4813 10.1007/s11356-021-12347-5 10.1155/2012/418912 10.3390/nu12113325 10.4162/nrp.2017.11.1.17 10.1093/bbb/zbab138 10.1007/s10068-017-0028-z 10.1007/s10126-008-9170-1 10.1038/414799a 10.4103/0976-500X.130158 10.1002/mnfr.201500021 10.1089/jmf.2013.0053 10.5650/jos.57.345 10.3390/md9081359 10.1016/j.ijbiomac.2014.10.013 10.4103/0973-7847.125514 10.1016/S0140-6736(10)60171-7 10.1007/s10753-013-9757-1 10.3390/md14120222 10.1271/bbb.60521 10.3945/jn.114.200931 10.1016/j.nut.2010.09.006 10.12691/jfnr-3-10-5 10.3390/md15040119 10.1016/j.bbrc.2007.12.019 10.1271/bbb.110137 10.1039/C9FO02857A 10.1016/j.fitote.2013.12.003 10.1093/ajcn/nqy147 10.1016/j.ijbiomac.2018.04.042 10.1016/j.ejphar.2009.05.017 10.3892/ijmm.2017.2869 10.1016/j.cbi.2010.04.003 10.1016/j.fct.2009.11.004 10.3390/molecules25163598 10.3390/md9061101 10.3390/molecules24203708 10.1016/j.nutres.2020.02.001 10.1016/j.fct.2010.06.032 10.1016/j.jff.2020.104168 10.1016/j.jff.2015.12.006 10.1111/j.1753-4887.2007.tb00278.x 10.1002/fsn3.2301 10.1152/ajpendo.2002.282.1.E46 10.1016/j.foodhyd.2015.02.019 10.3390/md13042196 10.1021/jf900820x 10.1111/jpy.12945 10.1111/nure.12091 10.1016/j.foodres.2020.109589 10.3390/md17110637 10.3390/nu11112773 10.4103/0257-7941.165629 10.1016/j.jff.2018.07.048 10.1038/ejcn.2014.53 10.1016/j.phymed.2011.11.001 10.1016/j.procbio.2011.09.015 10.3390/nu12123798 10.1016/j.jff.2021.104511 10.1152/ajpendo.00561.2001 10.1097/MPG.0b013e31826d3c62 10.1177/1559325820926765 10.3390/jcm8060854 10.1021/acs.jafc.0c02555 10.3390/nu13020551 10.1016/j.fshw.2015.08.001 10.1021/jf071569n 10.1097/TP.0b013e3181f6e267 10.3390/nu13061754 10.3390/nu11071513 10.1016/j.appet.2008.06.013 10.3390/md17090532 10.1016/j.nutres.2012.04.003 10.3390/nu9040342 10.4014/kjmb.1210.10003 10.3390/md12010128 10.3746/pnf.2012.17.2.129 10.1002/ptr.4965 10.3892/mmr_00000189 10.1159/000471488 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2023 MDPI AG 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023 by the authors. 2023 |
| Copyright_xml | – notice: COPYRIGHT 2023 MDPI AG – notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023 by the authors. 2023 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T7 7TN 7X7 7XB 88E 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI BKSAR C1K CCPQU DWQXO F1W FR3 FYUFA GHDGH GNUQQ H95 H99 HCIFZ K9. L.F L.G LK8 M0S M1P M7P P64 PCBAR PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI 7X8 7S9 L.6 5PM DOA |
| DOI | 10.3390/md21040258 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Industrial and Applied Microbiology Abstracts (Microbiology A) Oceanic Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Korea ASFA: Aquatic Sciences and Fisheries Abstracts Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources ASFA: Marine Biotechnology Abstracts SciTech Premium Collection (via ProQuest) ProQuest Health & Medical Complete (Alumni) Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts Aquatic Science & Fisheries Abstracts (ASFA) Professional Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts Earth, Atmospheric & Aquatic Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Aquatic Science & Fisheries Abstracts (ASFA) Professional ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Oceanic Abstracts Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ASFA: Aquatic Sciences and Fisheries Abstracts Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | Publicly Available Content Database AGRICOLA MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1660-3397 |
| ExternalDocumentID | oai_doaj_org_article_27ac7d671f9a42578f3094c975c0d3d6 PMC10142144 A750397995 37103396 10_3390_md21040258 |
| Genre | Journal Article Review |
| GeographicLocations | South Africa |
| GeographicLocations_xml | – name: South Africa |
| GrantInformation_xml | – fundername: National Research Foundation grantid: 133137 |
| GroupedDBID | --- 29M 2WC 53G 5GY 5VS 7X7 88E 8CJ 8FE 8FH 8FI 8FJ AADQD AAHBH AAYXX ABUWG ACGFO ACIHN ACPRK ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFRAH AFZYC AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS BANNL BAWUL BBNVY BCNDV BENPR BHPHI BKSAR BPHCQ BVXVI CCPQU CITATION CS3 D1J DIK DU5 E3Z EBD EDH F5P FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IHR ITC KQ8 LK5 LK8 M1P M48 M7P M7R MK0 MODMG M~E O5R O5S OK1 OVT P2P PCBAR PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO RNS RPM TR2 UKHRP XSB 3V. ALIPV CGR CUY CVF ECM EIF NPM 7T7 7TN 7XB 8FD 8FK AZQEC C1K DWQXO F1W FR3 GNUQQ H95 H99 K9. L.F L.G P64 PKEHL PQEST PQUKI 7X8 PUEGO 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c573t-1a97a8826067d75bb4de3b84d51c58f32c263966b4d21afba8e5f5db89c857fa3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 21 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000977416100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1660-3397 |
| IngestDate | Mon Nov 10 04:34:03 EST 2025 Tue Nov 04 02:06:52 EST 2025 Wed Oct 01 14:01:43 EDT 2025 Thu Oct 02 11:45:20 EDT 2025 Sat Nov 29 14:59:58 EST 2025 Sat Nov 29 14:00:45 EST 2025 Sun Nov 23 09:03:53 EST 2025 Thu Jan 02 22:53:12 EST 2025 Sat Nov 29 07:18:19 EST 2025 Tue Nov 18 20:41:44 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | bioactive compounds seaweeds marine macroalgae type 2 diabetes diabetes obesity |
| Language | English |
| License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c573t-1a97a8826067d75bb4de3b84d51c58f32c263966b4d21afba8e5f5db89c857fa3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0003-0309-9491 0000-0003-4885-6126 |
| OpenAccessLink | https://doaj.org/article/27ac7d671f9a42578f3094c975c0d3d6 |
| PMID | 37103396 |
| PQID | 2806553397 |
| PQPubID | 2032365 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_27ac7d671f9a42578f3094c975c0d3d6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10142144 proquest_miscellaneous_3040373884 proquest_miscellaneous_2806994679 proquest_journals_2806553397 gale_infotracmisc_A750397995 gale_infotracacademiconefile_A750397995 pubmed_primary_37103396 crossref_citationtrail_10_3390_md21040258 crossref_primary_10_3390_md21040258 |
| PublicationCentury | 2000 |
| PublicationDate | 20230421 |
| PublicationDateYYYYMMDD | 2023-04-21 |
| PublicationDate_xml | – month: 4 year: 2023 text: 20230421 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland – name: Basel |
| PublicationTitle | Marine drugs |
| PublicationTitleAlternate | Mar Drugs |
| PublicationYear | 2023 |
| Publisher | MDPI AG MDPI |
| Publisher_xml | – name: MDPI AG – name: MDPI |
| References | Li (ref_28) 2011; 46 Erpel (ref_63) 2020; 137 ref_91 Jung (ref_30) 2014; 92 ref_10 Lee (ref_100) 2014; 19 Jin (ref_118) 2021; 82 Nascimento (ref_125) 2018; 2018 Kim (ref_85) 2006; 79 ref_97 ref_96 ref_95 Kim (ref_71) 2012; 83 ref_16 Kumar (ref_20) 2015; 35 Kim (ref_23) 2012; 166 Kim (ref_50) 2015; 3 Brashier (ref_14) 2014; 5 Kim (ref_24) 2012; 55 Hu (ref_37) 2016; 21 ref_127 Lee (ref_92) 2010; 48 Oliyaei (ref_82) 2021; 9 Hribal (ref_6) 2002; 282 ref_121 Boachie (ref_11) 2022; 15 (ref_19) 2017; 9 Gammone (ref_27) 2015; 13 Wang (ref_45) 2014; 2 Park (ref_112) 2017; 26 Bailey (ref_15) 2017; 60 Du (ref_40) 2018; 48 Ko (ref_31) 2013; 36 Kim (ref_46) 2009; 11 Dufrane (ref_74) 2010; 90 Aoi (ref_66) 2008; 366 Paxman (ref_79) 2008; 51 Jeon (ref_94) 2015; 3 Eom (ref_89) 2012; 92 Chen (ref_68) 2020; 393 Wu (ref_105) 2018; 16 Du (ref_41) 2020; 74 Ikeuchi (ref_65) 2007; 71 Kershaw (ref_8) 2004; 89 Beppu (ref_80) 2012; 11 Takaichi (ref_33) 2011; 9 Nishikawa (ref_81) 2012; 19 Kim (ref_90) 2009; 57 Singh (ref_29) 2006; 23 Yeo (ref_86) 2012; 17 Kim (ref_119) 2017; 39 Draget (ref_52) 2011; 25 Goossens (ref_1) 2017; 10 Okada (ref_43) 2008; 57 Koh (ref_48) 2020; 11 Baldrick (ref_98) 2018; 108 Lange (ref_54) 2015; 4 MacArtain (ref_17) 2007; 65 Choi (ref_93) 2015; 59 Heo (ref_103) 2009; 615 Seo (ref_116) 2020; 17 Kang (ref_115) 2017; 11 Kim (ref_84) 2014; 28 Zheng (ref_35) 2018; 53 ref_57 Chang (ref_99) 2011; 27 Maeda (ref_26) 2015; 13 ref_53 Sekiya (ref_44) 2021; 85 Huang (ref_38) 2013; 56 Maeda (ref_58) 2009; 2 Zhang (ref_61) 2018; 48 Saltiel (ref_5) 2001; 414 Moon (ref_32) 2011; 75 Han (ref_3) 2010; 375 ref_69 Pedersen (ref_77) 2014; 14 Gheda (ref_62) 2021; 28 Yang (ref_122) 2015; 23 Bhuvaneswari (ref_67) 2010; 45 Jung (ref_87) 2013; 41 Yende (ref_107) 2014; 8 Woo (ref_120) 2013; 27 ref_114 ref_117 Ginsberg (ref_4) 2009; 4 Park (ref_123) 2012; 2012 Feng (ref_83) 2020; 18 Choi (ref_101) 2014; 23 Yip (ref_106) 2020; 56 Lakshmanasenthil (ref_49) 2015; 72 ref_111 ref_110 Gemello (ref_22) 2012; 10 Zheng (ref_64) 2020; 77 ref_113 Diraison (ref_36) 2002; 282 Wang (ref_72) 2018; 115 Choi (ref_75) 2011; 25 Wadden (ref_12) 2012; 125 Maeda (ref_25) 2006; 18 (ref_78) 2014; 17 ref_39 Zhao (ref_56) 2012; 24 Kazemipoor (ref_21) 2012; 39 Kim (ref_88) 2010; 186 Zhang (ref_70) 2020; 68 Goff (ref_76) 2014; 68 Li (ref_73) 2020; 11 ref_104 ref_108 Park (ref_51) 2011; 9 ref_109 Kang (ref_126) 2021; 48 Ambati (ref_42) 2014; 12 ref_102 Kim (ref_47) 2012; 32 Li (ref_34) 2015; 145 Brown (ref_18) 2014; 72 Maeda (ref_59) 2007; 55 ref_2 ref_9 Khera (ref_13) 2016; 315 Tan (ref_60) 2014; 37 Kim (ref_124) 2018; 41 ref_7 Houghton (ref_55) 2015; 49 |
| References_xml | – volume: 39 start-page: 164 year: 2012 ident: ref_21 article-title: Potential of Traditional Medicinal Plants for Treating Obesity: A Review publication-title: ICNFS – volume: 25 start-page: 1813 year: 2011 ident: ref_75 article-title: Effects of astaxanthin on oxidative stress in overweight and obese adults publication-title: PTR – volume: 45 start-page: 1406 year: 2010 ident: ref_67 article-title: Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed an obesity-promoting diet publication-title: Process Biochem. doi: 10.1016/j.procbio.2010.05.016 – volume: 23 start-page: 931 year: 2014 ident: ref_101 article-title: Xanthigen attenuates high-fat diet-induced obesity through down-regulation of PPARγ and activation of the AMPK pathway publication-title: Food Sci. Biotechnol. doi: 10.1007/s10068-014-0125-1 – ident: ref_9 – volume: 53 start-page: 41 year: 2018 ident: ref_35 article-title: Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity publication-title: Lipids doi: 10.1002/lipd.12002 – volume: 125 start-page: 1157 year: 2012 ident: ref_12 article-title: Lifestyle modification for obesity: New developments in diet, physical activity, and behavior therapy publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.111.039453 – volume: 11 start-page: 831 year: 2020 ident: ref_48 article-title: Structural Dependence of Sulfated Polysaccharide for Diabetes Management: Fucoidan From Undaria pinnatifida Inhibiting α-Glucosidase More Strongly Than α-Amylase and Amyloglucosidase publication-title: Front. Pharmacol. doi: 10.3389/fphar.2020.00831 – volume: 55 start-page: 477 year: 2012 ident: ref_24 article-title: Fucoxanthin as a major carotenoid in Isochrysis aff. galbana: Characterization of extraction for commercial application publication-title: J. Korean Soc. Appl. Biol. Chem. doi: 10.1007/s13765-012-2108-3 – volume: 4 start-page: 113 year: 2009 ident: ref_4 article-title: The obesity, metabolic syndrome, and type 2 diabetes mellitus pandemic: Part I. Increased cardiovascular disease risk and the importance of atherogenic dyslipidemia in persons with the metabolic syndrome and type 2 diabetes mellitus publication-title: J. Cardiometab. Syndr. doi: 10.1111/j.1559-4572.2008.00044.x – ident: ref_57 doi: 10.3390/md14080148 – volume: 11 start-page: 112 year: 2012 ident: ref_80 article-title: Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-A(y) mice publication-title: Lipids Health Dis. doi: 10.1186/1476-511X-11-112 – volume: 315 start-page: 2424 year: 2016 ident: ref_13 article-title: Association of Pharmacological Treatments for Obesity with Weight Loss and Adverse Events: A Systematic Review and Meta-analysis publication-title: J. Am. Med. Assoc. doi: 10.1001/jama.2016.7602 – volume: 60 start-page: 1566 year: 2017 ident: ref_15 article-title: Metformin: Historical overview publication-title: Diabetologia doi: 10.1007/s00125-017-4318-z – ident: ref_16 – volume: 79 start-page: 1436 year: 2006 ident: ref_85 article-title: Phlorotannins in Ecklonia cava extract inhibit matrix metalloproteinase activity publication-title: Life Sci. doi: 10.1016/j.lfs.2006.04.022 – volume: 17 start-page: 1 year: 2012 ident: ref_86 article-title: Anti-hyperlipidemic Effect of Polyphenol Extract (Seapolynol(™)) and Dieckol Isolated from Ecklonia cava in in vivo and in vitro Models publication-title: Prev. Nutr. Food Sci. doi: 10.3746/pnf.2012.17.1.001 – volume: 23 start-page: 558 year: 2006 ident: ref_29 article-title: Phloroglucinol compounds of natural origin publication-title: Nat. Prod. Rep. doi: 10.1039/b600518g – ident: ref_96 doi: 10.3390/md17110612 – volume: 15 start-page: 2045092 year: 2022 ident: ref_11 article-title: Estimating the healthcare cost of overweight and obesity in South Africa publication-title: Glob. Health Action doi: 10.1080/16549716.2022.2045092 – volume: 13 start-page: 4799 year: 2015 ident: ref_26 article-title: Fucoxanthinol, Metabolite of Fucoxanthin, Improves Obesity-Induced Inflammation in Adipocyte Cells publication-title: Mar. Drugs doi: 10.3390/md13084799 – volume: 89 start-page: 2548 year: 2004 ident: ref_8 article-title: Adipose tissue as an endocrine organ publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2004-0395 – ident: ref_69 doi: 10.3390/medicina56120634 – volume: 19 start-page: 913 year: 2014 ident: ref_100 article-title: Krill oil and xanthigen separately inhibit high fat diet induced obesity and hepatic triacylglycerol accumulation in mice publication-title: J. Funct. Foods doi: 10.1016/j.jff.2014.10.015 – volume: 393 start-page: 2517 year: 2020 ident: ref_68 article-title: Astaxanthin alleviates gestational diabetes mellitus in mice through suppression of oxidative stress publication-title: Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-020-01861-x – ident: ref_95 doi: 10.3390/md17050272 – volume: 23 start-page: 758 year: 2015 ident: ref_122 article-title: Red algae (Gelidium amansii) reduces adiposity via activation of lipolysis in rats with diabetes induced by streptozotocin-nicotinamide publication-title: J. Food Drug Analysis. doi: 10.1016/j.jfda.2015.06.003 – volume: 41 start-page: 924 year: 2018 ident: ref_124 article-title: Anti-obesity effects of pectinase and cellulase enzyme-treated Ecklonia cava extract in high-fat diet-fed C57BL/6N mice publication-title: Int. J. Mol. Med. – volume: 83 start-page: 1105 year: 2012 ident: ref_71 article-title: Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice publication-title: Fitoterapia doi: 10.1016/j.fitote.2012.04.027 – ident: ref_10 – volume: 48 start-page: 551 year: 2018 ident: ref_40 article-title: Inhibitory effect of astaxanthin on pancreatic lipase with inhibition kinetics integrating molecular docking simulation publication-title: J. Funct. Foods. doi: 10.1016/j.jff.2018.07.045 – volume: 10 start-page: 604 year: 2012 ident: ref_22 article-title: Fucoxantin: A treasure from the sea publication-title: Mar. Drugs doi: 10.3390/md10030604 – volume: 2018 start-page: 9354296 year: 2018 ident: ref_125 article-title: In Vivo Evaluation of the Antioxidant Activity and Protective Action of the Seaweed Gracilaria birdiae publication-title: Oxidat. Med. Cell. Longev. doi: 10.1155/2018/9354296 – volume: 36 start-page: 1253 year: 2013 ident: ref_31 article-title: Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes publication-title: Environ. Toxicol. Pharmacol. doi: 10.1016/j.etap.2013.10.011 – volume: 24 start-page: 295 year: 2012 ident: ref_56 article-title: Effect of molecular weight on the antioxidant property of low molecular weight alginate from Laminaria japonica publication-title: J. Appl. Phycol. doi: 10.1007/s10811-011-9679-y – volume: 92 start-page: 2084 year: 2012 ident: ref_89 article-title: α-Glucosidase- and α-amylase-inhibitory activities of phlorotannins from Eisenia bicyclis publication-title: J. Sci. Food Agric. doi: 10.1002/jsfa.5585 – ident: ref_117 doi: 10.3390/cells9040871 – volume: 166 start-page: 1843 year: 2012 ident: ref_23 article-title: A potential commercial source of fucoxanthin extracted from the microalga Phaeodactylum tricornutum publication-title: Appl. Biochem. Biotechnol. doi: 10.1007/s12010-012-9602-2 – volume: 25 start-page: 251 year: 2011 ident: ref_52 article-title: Chemical, physical and biological properties of alginates and their biomedical implications publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2009.10.007 – volume: 27 start-page: 1102 year: 2013 ident: ref_120 article-title: The edible red alga, Gracilaria verrucosa, inhibits lipid accumulation and ROS production, but improves glucose uptake in 3T3-L1 cells publication-title: Phytother. Res. doi: 10.1002/ptr.4813 – volume: 28 start-page: 22886 year: 2021 ident: ref_62 article-title: Antidiabetic and antioxidant activity of phlorotannins extracted from the brown seaweed Cystoseira compressa in streptozotocin-induced diabetic rats publication-title: Envrion. Sci. Poll. Res. Int. doi: 10.1007/s11356-021-12347-5 – volume: 2012 start-page: 418912 year: 2012 ident: ref_123 article-title: Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice publication-title: Evid. Based Complement Altern. Med. doi: 10.1155/2012/418912 – ident: ref_110 doi: 10.3390/nu12113325 – volume: 11 start-page: 17 year: 2017 ident: ref_115 article-title: Gelidium amansii extract ameliorates obesity by down-regulating adipogenic transcription factors in diet-induced obese mice publication-title: Nutr. Res. Pract. doi: 10.4162/nrp.2017.11.1.17 – volume: 85 start-page: 2145 year: 2021 ident: ref_44 article-title: Neoxanthin in young vegetable leaves prevents fat accumulation in differentiated adipocytes publication-title: Biosci. Biotechnol. Biochem. doi: 10.1093/bbb/zbab138 – volume: 26 start-page: 207 year: 2017 ident: ref_112 article-title: Gelidium amansii ethanol extract suppresses fat accumulation by down-regulating adipogenic transcription factors in ob/ob mice model publication-title: Food Sci. Biotechnol. doi: 10.1007/s10068-017-0028-z – volume: 11 start-page: 557 year: 2009 ident: ref_46 article-title: Inhibitory effects of Fucoidan in 3T3-L1 adipocyte differentiation publication-title: Mar. Biotechnol. doi: 10.1007/s10126-008-9170-1 – volume: 414 start-page: 799 year: 2001 ident: ref_5 article-title: Insulin signalling and the regulation of glucose and lipid metabolism publication-title: Nature doi: 10.1038/414799a – volume: 5 start-page: 175 year: 2014 ident: ref_14 article-title: Lorcaserin: A novel antiobesity drug publication-title: J. Pharmacol. Pharmacother. doi: 10.4103/0976-500X.130158 – volume: 59 start-page: 1458 year: 2015 ident: ref_93 article-title: Dieckol, a major phlorotannin in Ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell-cycle arrest and AMPKα activation publication-title: Mol. Nutr. Food Res. doi: 10.1002/mnfr.201500021 – volume: 2 start-page: 1 year: 2014 ident: ref_45 article-title: The Potential Applications of Marine Bioactives Against Diabetes and Obesity publication-title: Am. J. Mar. Sci. – volume: 17 start-page: 830 year: 2014 ident: ref_78 article-title: Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults publication-title: J. Med. Food. doi: 10.1089/jmf.2013.0053 – volume: 57 start-page: 345 year: 2008 ident: ref_43 article-title: Suppressive effect of neoxanthin on the differentiation of 3T3-L1 adipose cells publication-title: J. Oleo. Sci. doi: 10.5650/jos.57.345 – volume: 9 start-page: 1359 year: 2011 ident: ref_51 article-title: Fucoidan from Marine Brown Algae Inhibits Lipid Accumulation publication-title: Mar. Drugs doi: 10.3390/md9081359 – volume: 72 start-page: 1044 year: 2015 ident: ref_49 article-title: Fucoidan—A α-D-glucosidase inhibitor from Sargassum wightii with relevance to type 2 diabetes mellitus therapy publication-title: Int. J. Biol. Macromol. doi: 10.1016/j.ijbiomac.2014.10.013 – volume: 8 start-page: 1 year: 2014 ident: ref_107 article-title: Therapeutic potential and health benefits of Sargassum species publication-title: Pharmacogn. Rev. doi: 10.4103/0973-7847.125514 – volume: 375 start-page: 1737 year: 2010 ident: ref_3 article-title: Childhood obesity publication-title: Lancet doi: 10.1016/S0140-6736(10)60171-7 – volume: 37 start-page: 443 year: 2014 ident: ref_60 article-title: First evidence for the anti-inflammatory activity of fucoxanthin in high-fat-diet-induced obesity in mice and the antioxidant functions in PC12 cells publication-title: Inflammation doi: 10.1007/s10753-013-9757-1 – ident: ref_53 doi: 10.3390/md14120222 – volume: 71 start-page: 893 year: 2007 ident: ref_65 article-title: Effects of astaxanthin in obese mice fed a high-fat diet publication-title: Biosci. Biotechnol. Biochem. doi: 10.1271/bbb.60521 – volume: 145 start-page: 490 year: 2015 ident: ref_34 article-title: The green algal carotenoid siphonaxanthin inhibits adipogenesis in 3T3-L1 preadipocytes and the accumulation of lipids in white adipose tissue of KK-Ay mice publication-title: J. Nutr. doi: 10.3945/jn.114.200931 – volume: 27 start-page: 463 year: 2011 ident: ref_99 article-title: Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice publication-title: Nutrition doi: 10.1016/j.nut.2010.09.006 – volume: 3 start-page: 648 year: 2015 ident: ref_94 article-title: Seapolynol and Dieckol Improve Insulin Sensitivity through the Regulation of the PI3K Pathway in C57BL/KsJ-db/db Mice publication-title: J. Food Nutr. Res. doi: 10.12691/jfnr-3-10-5 – ident: ref_91 doi: 10.3390/md15040119 – volume: 366 start-page: 892 year: 2008 ident: ref_66 article-title: Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2007.12.019 – volume: 75 start-page: 1472 year: 2011 ident: ref_32 article-title: Protein tyrosine phosphatase 1B and α-glucosidase inhibitory Phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis publication-title: Biosci. Biotechnol. Biochem. doi: 10.1271/bbb.110137 – volume: 14 start-page: 129 year: 2014 ident: ref_77 article-title: Review: Efficacy of alginate supplementation in relation to appetite regulation and metabolic risk factors: Evidence from animal and human studies publication-title: Obes. Rev. Off. J. Int. Assoc. Study Obes. – volume: 16 start-page: 344 year: 2018 ident: ref_105 article-title: L-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice publication-title: J. Trnals. Med. – volume: 11 start-page: 4773 year: 2020 ident: ref_73 article-title: Unsaturated alginate oligosaccharides attenuated obesity-related metabolic abnormalities by modulating gut microbiota in high-fat-diet mice publication-title: Food Funct. doi: 10.1039/C9FO02857A – volume: 92 start-page: 260 year: 2014 ident: ref_30 article-title: Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ publication-title: Fitoterapia doi: 10.1016/j.fitote.2013.12.003 – volume: 108 start-page: 688 year: 2018 ident: ref_98 article-title: Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: A randomized controlled trial publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/nqy147 – volume: 115 start-page: 861 year: 2018 ident: ref_72 article-title: Transcriptome analysis revealed anti-obesity effects of the Sodium Alginate in high-fat diet-induced obese mice publication-title: Int. J. Biol. Marcomol. doi: 10.1016/j.ijbiomac.2018.04.042 – volume: 615 start-page: 252 year: 2009 ident: ref_103 article-title: Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent alpha-glucosidase and alpha-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2009.05.017 – volume: 39 start-page: 636 year: 2017 ident: ref_119 article-title: Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes publication-title: Int. J. Mol. Med. doi: 10.3892/ijmm.2017.2869 – volume: 3 start-page: 108 year: 2015 ident: ref_50 article-title: Molecular weight and sulfate content modulate the inhibition of α-amylase by fucoidan relevant for type 2 diabetes management publication-title: Pharma Nutr. – volume: 186 start-page: 24 year: 2010 ident: ref_88 article-title: Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes publication-title: Chemico-Biological Interact. doi: 10.1016/j.cbi.2010.04.003 – volume: 48 start-page: 509 year: 2021 ident: ref_126 article-title: Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2009.11.004 – ident: ref_39 doi: 10.3390/molecules25163598 – volume: 9 start-page: 1101 year: 2011 ident: ref_33 article-title: Carotenoids in Algae: Distributions, Biosyntheses and Functions publication-title: Mar. Drugs doi: 10.3390/md9061101 – ident: ref_127 doi: 10.3390/molecules24203708 – volume: 77 start-page: 29 year: 2020 ident: ref_64 article-title: Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity publication-title: Nutr. Res. doi: 10.1016/j.nutres.2020.02.001 – volume: 48 start-page: 2633 year: 2010 ident: ref_92 article-title: Dieckol isolated from Ecklonia cava inhibits alpha-glucosidase and alpha-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice publication-title: Food Chem. Toxicol. doi: 10.1016/j.fct.2010.06.032 – volume: 74 start-page: 104168 year: 2020 ident: ref_41 article-title: Hypoglycaemic effect of all-trans astaxanthin through inhibiting α-glucosidase publication-title: J. Funct. Foods doi: 10.1016/j.jff.2020.104168 – volume: 21 start-page: 372 year: 2016 ident: ref_37 article-title: Marine-derived bioactive compounds with anti-obesity effect: A review publication-title: J. Funct. Foods doi: 10.1016/j.jff.2015.12.006 – volume: 65 start-page: 535 year: 2007 ident: ref_17 article-title: Nutritional value of edible seaweeds publication-title: Nutr. Rev. doi: 10.1111/j.1753-4887.2007.tb00278.x – volume: 9 start-page: 2050 year: 2017 ident: ref_19 article-title: Medicinal plants for the treatment of obesity: Ethnopharmacological approach and chemical and biological studies publication-title: Am. J. Transl. Res. – volume: 9 start-page: 3521 year: 2021 ident: ref_82 article-title: Antidiabetic effect of fucoxanthin extracted from Sargassum angustifolium on streptozotocin-nicotinamide-induced type 2 diabetic mice publication-title: Food Sci. Nutr. doi: 10.1002/fsn3.2301 – volume: 282 start-page: 46 year: 2002 ident: ref_36 article-title: Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.2002.282.1.E46 – volume: 49 start-page: 18 year: 2015 ident: ref_55 article-title: Biological activity of alginate and its effect on pancreatic lipase inhibition as a potential treatment for obesity publication-title: Food Hydrocoll. doi: 10.1016/j.foodhyd.2015.02.019 – volume: 13 start-page: 2196 year: 2015 ident: ref_27 article-title: Anti-obesity activity of the marine carotenoid fucoxanthin publication-title: Mar. Drugs doi: 10.3390/md13042196 – volume: 57 start-page: 3483 year: 2009 ident: ref_90 article-title: Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties publication-title: J. Agric. Food Chem. doi: 10.1021/jf900820x – volume: 56 start-page: 300 year: 2020 ident: ref_106 article-title: Historical biogeography of the widespread macroalga Sargassum (Fucales, Phaeophyceae) publication-title: J. Phycol. doi: 10.1111/jpy.12945 – volume: 18 start-page: 147 year: 2006 ident: ref_25 article-title: Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells publication-title: Int. J. Mol. Med. – volume: 72 start-page: 205 year: 2014 ident: ref_18 article-title: Seaweed and human health publication-title: Nutr. Rev. doi: 10.1111/nure.12091 – volume: 137 start-page: 109589 year: 2020 ident: ref_63 article-title: Phlorotannins: From isolation and structural characterization, to the evaluation of their antidiabetic and anticancer potential publication-title: Food Res. Int. doi: 10.1016/j.foodres.2020.109589 – ident: ref_102 doi: 10.3390/md17110637 – ident: ref_97 doi: 10.3390/nu11112773 – volume: 35 start-page: 58 year: 2015 ident: ref_20 article-title: Common medicinal plants with antiobesity potential: A special emphasis on fenugreek publication-title: Anc. Sci. Life doi: 10.4103/0257-7941.165629 – volume: 48 start-page: 515 year: 2018 ident: ref_61 article-title: Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathway publication-title: J. Funct. Foods. doi: 10.1016/j.jff.2018.07.048 – volume: 68 start-page: 613 year: 2014 ident: ref_76 article-title: Effect of sodium alginate addition to chocolate milk on glycemia, insulin, appetite and food intake in healthy adult men publication-title: Eur. J. Clin. Nutr. doi: 10.1038/ejcn.2014.53 – volume: 19 start-page: 389 year: 2012 ident: ref_81 article-title: Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice publication-title: Phytomedicine doi: 10.1016/j.phymed.2011.11.001 – volume: 46 start-page: 2219 year: 2011 ident: ref_28 article-title: Phlorotannins as bioactive agents from brown algae publication-title: Process Biochem. doi: 10.1016/j.procbio.2011.09.015 – ident: ref_104 doi: 10.3390/nu12123798 – volume: 82 start-page: 104511 year: 2021 ident: ref_118 article-title: Effects of Ecklonia stolonifera extract on the obesity and skeletal muscle regeneration in high-fat diet-fed mice publication-title: J. Funct. Foods. doi: 10.1016/j.jff.2021.104511 – volume: 282 start-page: 977 year: 2002 ident: ref_6 article-title: Mouse models of insulin resistance publication-title: Am. J. Physiol. Endocrinol. Metab. doi: 10.1152/ajpendo.00561.2001 – volume: 56 start-page: 99 year: 2013 ident: ref_38 article-title: Childhood obesity for pediatric gastroenterologists publication-title: J. Pediatr. Gastroenterol. Nutr. doi: 10.1097/MPG.0b013e31826d3c62 – volume: 18 start-page: 1559325820926765 year: 2020 ident: ref_83 article-title: Effects of Astaxanthin on Inflammation and Insulin Resistance in a Mouse Model of Gestational Diabetes Mellitus publication-title: Dose-Response doi: 10.1177/1559325820926765 – ident: ref_7 doi: 10.3390/jcm8060854 – volume: 68 start-page: 10626 year: 2020 ident: ref_70 article-title: Sargassum fusiforme Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile publication-title: J. Agric. Food Chem. doi: 10.1021/acs.jafc.0c02555 – ident: ref_109 doi: 10.3390/nu13020551 – volume: 4 start-page: 87 year: 2015 ident: ref_54 article-title: Dietary seaweeds and obesity publication-title: Food Sci. Hum. Wellness. doi: 10.1016/j.fshw.2015.08.001 – volume: 55 start-page: 7701 year: 2007 ident: ref_59 article-title: Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice publication-title: J. Agric. Food Chem. doi: 10.1021/jf071569n – volume: 90 start-page: 1054 year: 2010 ident: ref_74 article-title: Alginate macroencapsulation of pig islets allows correction of streptozotocin-induced diabetes in primates up to 6 months without immunosuppression publication-title: Transplantation doi: 10.1097/TP.0b013e3181f6e267 – ident: ref_108 doi: 10.3390/nu13061754 – ident: ref_114 doi: 10.3390/nu11071513 – ident: ref_111 – volume: 51 start-page: 713 year: 2008 ident: ref_79 article-title: Daily ingestion of alginate reduces energy intake in free-living subjects publication-title: Appetite doi: 10.1016/j.appet.2008.06.013 – ident: ref_121 doi: 10.3390/md17090532 – volume: 32 start-page: 439 year: 2012 ident: ref_47 article-title: Fucoidan from the sporophyll of Undaria pinnatifida suppresses adipocyte differentiation by inhibition of inflammation-related cytokines in 3T3-L1 cells publication-title: Nutr. Res. doi: 10.1016/j.nutres.2012.04.003 – ident: ref_2 – ident: ref_113 doi: 10.3390/nu9040342 – volume: 41 start-page: 112 year: 2013 ident: ref_87 article-title: Lipase Inhibitory Mode of Dieckol Isolated from Eisenia bicyclis Ethanol Extract publication-title: Korean J. Microbiol. Biotechnol. doi: 10.4014/kjmb.1210.10003 – volume: 12 start-page: 128 year: 2014 ident: ref_42 article-title: Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications—A review publication-title: Mar. Drugs doi: 10.3390/md12010128 – volume: 17 start-page: 129 year: 2020 ident: ref_116 article-title: Extract from Edible Red Seaweed (Gelidium amansii) Inhibits Lipid Accumulation and ROS Production during Differentiation in 3T3-L1 Cells publication-title: Prev. Nutr. Food Sci. doi: 10.3746/pnf.2012.17.2.129 – volume: 28 start-page: 137 year: 2014 ident: ref_84 article-title: Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation publication-title: Phytother. Res. doi: 10.1002/ptr.4965 – volume: 2 start-page: 897 year: 2009 ident: ref_58 article-title: Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model publication-title: Mol. Med. Rep. doi: 10.3892/mmr_00000189 – volume: 10 start-page: 207 year: 2017 ident: ref_1 article-title: The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function publication-title: Obes. Facts. doi: 10.1159/000471488 |
| SSID | ssj0035894 |
| Score | 2.4662824 |
| SecondaryResourceType | review_article |
| Snippet | Obesity and diabetes are matters of serious concern in the health sector due to their rapid increase in prevalence over the last three decades. Obesity is a... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 258 |
| SubjectTerms | Algae Animals Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use Bioactive compounds Biological activity Biological products Body weight Care and treatment Carnitine Chemical properties Chronic illnesses Clinical trials Developing countries diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy energy Food and Drug Administration Health aspects In vivo methods and tests Insulin Insulin resistance LDCs macroalgae Marine algae marine macroalgae noninsulin-dependent diabetes mellitus Obesity Obesity - drug therapy Overweight - drug therapy Review Seaweed Seaweeds Side effects Type 2 diabetes |
| SummonAdditionalLinks | – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagcODC-xEoyAhUhLQRmzhe21zQFlFxgLKCIvUW-RUaCSUl2YL6F_jVzDjeR8Tjwmm18XgTb8bz8Mx8Q8jTQijrC81SUL3YwmzqUllweCFeFQZYCoyKUCj8ThweyuNjtYgHbn1Mq1zJxCCoXWvxjPxFiACCbaLEq9NvKXaNwuhqbKFxkVxClIQ8pO4tVpKYcamKAZIU5k3BxQf_BvwlbO--pYQCVv_vEnlLJY3TJbf0z8G1_33y6-RqtDzpfGCVG-SCb26SvcUAXX0-oUebSqx-QvfoYgNqfX6L_PyIyE-0reh7jQWD8AFrw0IQT9uOfvL6B-jBnurG4S_VHd2vWx2EKUWZg92belo3-MVozLWmH0JONh4OTGjsTxCmxySd_iWdh6mdPxmy7OkQyLhNPh-8OXr9No19HFLLBVummVZCgyUPvpJwghtTOM-MLBzPLJcVy20OdtJsBtfzTFdGS88r7oxUVnJRaXaH7DRt4-8R6rGi3EjBlAQ_joMqNSa3SlWZFmDMuoQ8X73Y0kaQc-y18bUEZweZoNwwQUKerGlPB2iPP1LtI3-sKRCOO1xouy9l3N1lLrQVbiaySukgBCsGbrNVgtupY26WkGfIXSUKDXgcq2PtAywK4bfKOUaTMcDKE7I7ooTNbsfDKx4ro7Dpyw2DJeTxehhnYgJd49uzgUYp0Irq7zQMVoxAV7JIyN2B5dfLZmCJwh1gJXK0GUb_y3ikqU8CXDl2g0Zgvvv_fvYH5EoOBiRG6vJsl-wsuzP_kFy235d13z0KG_sXOLpYCw priority: 102 providerName: ProQuest |
| Title | Roles of Marine Macroalgae or Seaweeds and Their Bioactive Compounds in Combating Overweight, Obesity and Diabetes: A Comprehensive Review |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/37103396 https://www.proquest.com/docview/2806553397 https://www.proquest.com/docview/2806994679 https://www.proquest.com/docview/3040373884 https://pubmed.ncbi.nlm.nih.gov/PMC10142144 https://doaj.org/article/27ac7d671f9a42578f3094c975c0d3d6 |
| Volume | 21 |
| WOSCitedRecordID | wos000977416100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: DOA dateStart: 20030101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: M~E dateStart: 20030101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database (Proquest) customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: M7P dateStart: 20030101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: PCBAR dateStart: 20030101 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection (Proquest) customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: 7X7 dateStart: 20030101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: BENPR dateStart: 20030101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1660-3397 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0035894 issn: 1660-3397 databaseCode: PIMPY dateStart: 20030101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELdg8MAL4puMURmBhpAarYnj2uatRZtAYiUaQypPkeM4WiSUoKQb2r_AX82dnX5EgHjhpVXtS2r7zr47-e53hLxKhDI20SwE1YslzCZFKBMODLEqyUGkwKhwicIfxWIhl0uV7pT6wpgwDw_sF-4oFtqIYiqiUmknXyUDj8Qowc2kYIUD254ItXam_BnMuFSJByNl4NSDcw-eDXhKWNh9R_04lP7fz-IdZTQMlNzRPCf3yN3eZKQzP9T75IatH5DD1GNOX4_p-TaFqhvTQ5pu0aivH5KfZwjZRJuSnmrM9IMvGBpmcFjatPSz1T9AgXVU1wW-qWrpvGq0OwUpHhZYdqmjVY0_co1B0vSTC6ZGr35M-8IC7vE-uqZ7S2fu0dZe-PB46m8gHpEvJ8fn796HfQGG0HDBVmGkldBggoOTIwrB8zwpLMtlUvDIcGBEbGIwcKZTaI8jXeZaWl7yIpfKSC5KzR6Tvbqp7VNCLaaC51IwJcEB46AD8zw2SpWRFmCFFgF5s-ZLZnp0ciyS8S0DLwV5mG15GJCXG9rvHpPjj1RzZO-GAnG0XQNIV9ZLV_Yv6QrIaxSODHc7DMfoPmkBJoW4WdkMr4HxZpQH5GBACbvUDLvX4pX1p0SXuVttsLeVCMiLTTc-iZFvtW0uPY1SoM7U32kYzBgRqmQSkCdeYjfTZmBCwj_ATORAlgfrMuypqwuHM45lnBFRb_9_rOQzcicG-xAv4uLogOyt2kv7nNw2V6uqa0fkplgK9ylH5Nb8eJGejdyOHmEwbgpt6YfT9OsvTUZPcQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3rb9MwELdGhwRfeD8CA4yAIaRGax6ubSSEOmBatbZUUKTxKTiOwyJBMpKOqf8Cfwx_I3d5tI14fNsHPlWNz4ntnO_OubvfEfLY51IbX3k2qF4sYdaLbOEzeCFG-iGwFBgVZaLwiE8m4vBQTjfIzyYXBsMqG5lYCuoo0_iNfKf0AIJtIvnL4282Vo1C72pTQqNiiwOzOIUjW_Fi-Bre7xPX3Xsze7Vv11UFbM24N7cdJbkCuxIsdx5xFoZ-ZLxQ-BFzNBOx52oXtHa_D9ddR8WhEobFLAqF1ILxWHlw33Nk00dm75DN6XA8_djIfo8J6VcgqDDS3s5XuAXsEhcLyq-pvbI6wO86YE0JtgM01zTe3uX_ba2ukEu1bU0H1Wa4SjZMeo1sTytw7kWXzla5ZkWXbtPpCrZ7cZ38eIfYVjSL6VhhSiT8wFpiqouhWU7fG3UKmr6gKo3wTklOd5NMleqColTF-lQFTVL8EyqMJqdvy6hz_PzRpXUFhrJ7HYZUPKeDsmtujqo8Alq5am6QD2eyTjdJJ81Sc5tQgznzoeCeFHBSZWAshKGrpYwdxcFcjyzyrGGkQNcw7lhN5EsAxzlkumDFdBZ5tKQ9rsBL_ki1i_y4pEDA8fJCln8OavkVuFxpHvW5E0tVivnY60lfS850L_KivkWeIjcHKBZhOFrV2R0wKQQYCwboL0cXMrPIVosSxJluNzc8HdTitAhWDG2Rh8tm7IkhgqnJTioaKUHvy7_TeDBjhPISvkVuVVtsOW0PbG14AsxEtDZfa13aLWlyVAKyY71rhB688--xPyAX9mfjUTAaTg7ukosumMvol3SdLdKZ5yfmHjmvv8-TIr9fixVKPp317vwFocO3BA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFLZGhxAv3C-BAUbAEFKjNhfXNhJCHaOi2lYiGNL2lDmOwypBMpKOqX-Bn8Sv45xc2kZc3vbAU9X4OLGd43M-59wIeepzqY2vPBtUL5Yw68e28Bm8ECP9CFgKQEUZKLzLJxNxcCCDNfKziYVBt8pGJpaCOs40fiPvlRZAwCaS95LaLSLYHr0--WZjBSm0tDblNCoW2THzMzi-Fa_G2_Cun7nu6O3-m3d2XWHA1ox7M9tRkivAmIDiecxZFPmx8SLhx8zRTCSeq13Q4IMBXHcdlURKGJawOBJSC8YT5cF9L5B1gOS-2yHrwXgvOGz0gMeE9KuEqDDqfu8r3AJ2jIvF5VdUYFkp4Hd9sKIQ286aK9pvdPV_Xrdr5EqNuemw2iTXyZpJb5DNoEraPe_S_WUMWtGlmzRYpvOe3yQ_PmDOK5oldE9hqCT8wLpiCIyhWU4_GnUGCKCgKo3xTtOcbk0zVaoRitIW61YVdJrin0ihlzl9X3qj42eRLq0rM5Tda_ek4iUdll1zc1zFF9DKhHOLfDqXdbpNOmmWmruEGoyljwT3pIATLAMQEUWuljJxFAcYH1vkRcNUoa7Tu2OVkS8hHPOQAcMlA1rkyYL2pEpq8keqLeTNBQUmIi8vZPnnsJZrocuV5vGAO4lUpfhPvL70teRM92MvHljkOXJ2iOIShqNVHfUBk8LEY-EQ7ehoWmYW2WhRgpjT7eaGv8NazBbhkrkt8njRjD3RdTA12WlFIyXgAfl3Gg9mjCm-hG-RO9V2W0zbAwwOT4CZiNZGbK1LuyWdHpeJ2rEONqYkvPfvsT8il2BLhrvjyc59ctkFFI3mStfZIJ1ZfmoekIv6-2xa5A9rCUPJ0Xlvzl-0jr_E |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Roles+of+Marine+Macroalgae+or+Seaweeds+and+Their+Bioactive+Compounds+in+Combating+Overweight%2C+Obesity+and+Diabetes%3A+A+Comprehensive+Review&rft.jtitle=Marine+drugs&rft.au=Magwaza%2C+S%E2%80%99thandiwe+Nozibusiso&rft.au=Islam%2C+Md+Shahidul&rft.date=2023-04-21&rft.issn=1660-3397&rft.eissn=1660-3397&rft.volume=21&rft.issue=4&rft_id=info:doi/10.3390%2Fmd21040258&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1660-3397&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1660-3397&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1660-3397&client=summon |