Effects of rubidium on responses to potassium channel openers in rat isolated aorta

1. In a physiological salt solution (PSS) in which potassium (K) was replaced by rubidium (Rb), segments of rat aorta precontracted with 20 mM RbCl were fully relaxed by K-channel openers with an order of potency levcromakalim > cromakalim > aprikalim > RP 49356. These relaxations were inhi...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 109; no. 4; p. 925
Main Authors:	Greenwood, I A, Weston, A H
Format:	Journal Article
Language:	English
Published:	England 01.08.1993
Subjects:	Animals Antihypertensive Agents - pharmacology Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Benzopyrans - pharmacology Cromakalim In Vitro Techniques Male Microelectrodes Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Picolines - pharmacology Portal Vein - drug effects Portal Vein - metabolism Potassium Channels - drug effects Potassium Chloride - pharmacology Potassium Radioisotopes Pyrans - pharmacology Pyrroles - pharmacology Rats Rats, Sprague-Dawley Rubidium - pharmacology Rubidium Radioisotopes Tachyphylaxis - physiology Vasodilator Agents - pharmacology
ISSN:	0007-1188
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