Induction of a glibenclamide-sensitive K-current by modification of a delayed rectifier channel in rat portal vein in insulinoma cells

In insulinoma cells (RINm5F), the glibenclamide-sensitive K-current (IK(ATP)) which developed spontaneously or after exposure to levcromakalim or to butanedione monoxime was always accompanied by a reduction in the delayed rectifier current (IK(V)). At potentials over which IK(V) was fully activated...

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Bibliographic Details

Published in:	British journal of pharmacology Vol. 110; no. 4; p. 1280
Main Authors:	Edwards, G, Weston, A H
Format:	Journal Article
Language:	English
Published:	England 01.12.1993
Subjects:	Animals Benzopyrans - pharmacology Cromakalim Glyburide - pharmacology Insulinoma - metabolism Neurotoxins - pharmacology Phosphorylation Portal Vein - drug effects Portal Vein - metabolism Potassium Channels - drug effects Potassium Channels - physiology Pyrroles - pharmacology Rats Scorpion Venoms Tumor Cells, Cultured
ISSN:	0007-1188
Online Access:	Get more information
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