Complement activation and endothelial perturbation parallel COVID-19 severity and activity

Animal models and few clinical reports suggest the involvement of the complement system in the onset of severe manifestations of coronavirus disease-2019 (COVID-19). However, complement contribution to endotheliopathy and hypercoagulability has not been elucidated yet. To evaluate the association am...

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Veröffentlicht in:	Journal of autoimmunity Jg. 116; S. 102560
Hauptverfasser:	Cugno, Massimo, Meroni, Pier Luigi, Gualtierotti, Roberta, Griffini, Samantha, Grovetti, Elena, Torri, Adriana, Lonati, Paola, Grossi, Claudia, Borghi, Maria Orietta, Novembrino, Cristina, Boscolo, Massimo, Uceda Renteria, Sara Colonia, Valenti, Luca, Lamorte, Giuseppe, Manunta, Maria, Prati, Daniele, Pesenti, Antonio, Blasi, Francesco, Costantino, Giorgio, Gori, Andrea, Bandera, Alessandra, Tedesco, Francesco, Peyvandi, Flora
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.01.2021 Published by Elsevier Ltd
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers - blood C5a Cohort Studies Complement Complement Activation - physiology COVID-19 COVID-19 - blood Endothelium Endothelium, Vascular - physiopathology Female Humans Male Middle Aged SARS-CoV-2 SC5b-9 von Willebrand factor COVID-19 SC5b-9 Complement von Willebrand factor C5a Endothelium
ISSN:	0896-8411, 1095-9157, 1095-9157
Online-Zugang:	Volltext
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