Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA
Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke. The purpose of this study was to determine whether complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) are associated with recurrent ischemic stroke or transient ischemic att...
Uloženo v:
| Vydáno v: | Journal of the American College of Cardiology Ročník 79; číslo 22; s. 2189 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
07.06.2022
|
| Témata: | |
| ISSN: | 1558-3597, 1558-3597 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.
The purpose of this study was to determine whether complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) are associated with recurrent ischemic stroke or transient ischemic attack (TIA).
The CAPIAS (Carotid Plaque Imaging in Acute Stroke) multicenter study prospectively recruited patients with ischemic stroke restricted to the territory of a single carotid artery. Complicated (AHA-lesion type VI) CAP were defined by multisequence, contrast-enhanced carotid magnetic resonance imaging obtained within 10 days from stroke onset. Recurrent events were assessed after 3, 12, 24, and 36 months. The primary outcome was recurrent ischemic stroke or TIA.
Among 196 patients enrolled, 104 patients had cryptogenic stroke and nonstenosing CAP. During a mean follow-up of 30 months, recurrent ischemic stroke or TIA occurred in 21 patients. Recurrent events were significantly more frequent in patients with icCAP than in patients without icCAP, both in the overall cohort (incidence rate [3-year interval]: 9.50 vs 3.61 per 100 patient-years; P = 0.025, log-rank test) and in patients with cryptogenic stroke (10.92 vs 1.82 per 100 patient-years; P = 0.003). The results were driven by ipsilateral events. A ruptured fibrous cap (HR: 4.91; 95% CI: 1.31-18.45; P = 0.018) and intraplaque hemorrhage (HR: 4.37; 95% CI: 1.20-15.97; P = 0.026) were associated with a significantly increased risk of recurrent events in patients with cryptogenic stroke.
Complicated CAP ipsilateral to acute ischemic anterior circulation stroke are associated with an increased risk of recurrent ischemic stroke or TIA. Carotid plaque imaging identifies high-risk patients who might be suited for inclusion into future secondary prevention trials. (Carotid Plaque Imaging in Acute Stroke [CAPIAS]; NCT01284933). |
|---|---|
| AbstractList | Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.
The purpose of this study was to determine whether complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) are associated with recurrent ischemic stroke or transient ischemic attack (TIA).
The CAPIAS (Carotid Plaque Imaging in Acute Stroke) multicenter study prospectively recruited patients with ischemic stroke restricted to the territory of a single carotid artery. Complicated (AHA-lesion type VI) CAP were defined by multisequence, contrast-enhanced carotid magnetic resonance imaging obtained within 10 days from stroke onset. Recurrent events were assessed after 3, 12, 24, and 36 months. The primary outcome was recurrent ischemic stroke or TIA.
Among 196 patients enrolled, 104 patients had cryptogenic stroke and nonstenosing CAP. During a mean follow-up of 30 months, recurrent ischemic stroke or TIA occurred in 21 patients. Recurrent events were significantly more frequent in patients with icCAP than in patients without icCAP, both in the overall cohort (incidence rate [3-year interval]: 9.50 vs 3.61 per 100 patient-years; P = 0.025, log-rank test) and in patients with cryptogenic stroke (10.92 vs 1.82 per 100 patient-years; P = 0.003). The results were driven by ipsilateral events. A ruptured fibrous cap (HR: 4.91; 95% CI: 1.31-18.45; P = 0.018) and intraplaque hemorrhage (HR: 4.37; 95% CI: 1.20-15.97; P = 0.026) were associated with a significantly increased risk of recurrent events in patients with cryptogenic stroke.
Complicated CAP ipsilateral to acute ischemic anterior circulation stroke are associated with an increased risk of recurrent ischemic stroke or TIA. Carotid plaque imaging identifies high-risk patients who might be suited for inclusion into future secondary prevention trials. (Carotid Plaque Imaging in Acute Stroke [CAPIAS]; NCT01284933). Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.BACKGROUNDComplicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.The purpose of this study was to determine whether complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) are associated with recurrent ischemic stroke or transient ischemic attack (TIA).OBJECTIVESThe purpose of this study was to determine whether complicated CAP ipsilateral to acute ischemic anterior circulation stroke (icCAP) are associated with recurrent ischemic stroke or transient ischemic attack (TIA).The CAPIAS (Carotid Plaque Imaging in Acute Stroke) multicenter study prospectively recruited patients with ischemic stroke restricted to the territory of a single carotid artery. Complicated (AHA-lesion type VI) CAP were defined by multisequence, contrast-enhanced carotid magnetic resonance imaging obtained within 10 days from stroke onset. Recurrent events were assessed after 3, 12, 24, and 36 months. The primary outcome was recurrent ischemic stroke or TIA.METHODSThe CAPIAS (Carotid Plaque Imaging in Acute Stroke) multicenter study prospectively recruited patients with ischemic stroke restricted to the territory of a single carotid artery. Complicated (AHA-lesion type VI) CAP were defined by multisequence, contrast-enhanced carotid magnetic resonance imaging obtained within 10 days from stroke onset. Recurrent events were assessed after 3, 12, 24, and 36 months. The primary outcome was recurrent ischemic stroke or TIA.Among 196 patients enrolled, 104 patients had cryptogenic stroke and nonstenosing CAP. During a mean follow-up of 30 months, recurrent ischemic stroke or TIA occurred in 21 patients. Recurrent events were significantly more frequent in patients with icCAP than in patients without icCAP, both in the overall cohort (incidence rate [3-year interval]: 9.50 vs 3.61 per 100 patient-years; P = 0.025, log-rank test) and in patients with cryptogenic stroke (10.92 vs 1.82 per 100 patient-years; P = 0.003). The results were driven by ipsilateral events. A ruptured fibrous cap (HR: 4.91; 95% CI: 1.31-18.45; P = 0.018) and intraplaque hemorrhage (HR: 4.37; 95% CI: 1.20-15.97; P = 0.026) were associated with a significantly increased risk of recurrent events in patients with cryptogenic stroke.RESULTSAmong 196 patients enrolled, 104 patients had cryptogenic stroke and nonstenosing CAP. During a mean follow-up of 30 months, recurrent ischemic stroke or TIA occurred in 21 patients. Recurrent events were significantly more frequent in patients with icCAP than in patients without icCAP, both in the overall cohort (incidence rate [3-year interval]: 9.50 vs 3.61 per 100 patient-years; P = 0.025, log-rank test) and in patients with cryptogenic stroke (10.92 vs 1.82 per 100 patient-years; P = 0.003). The results were driven by ipsilateral events. A ruptured fibrous cap (HR: 4.91; 95% CI: 1.31-18.45; P = 0.018) and intraplaque hemorrhage (HR: 4.37; 95% CI: 1.20-15.97; P = 0.026) were associated with a significantly increased risk of recurrent events in patients with cryptogenic stroke.Complicated CAP ipsilateral to acute ischemic anterior circulation stroke are associated with an increased risk of recurrent ischemic stroke or TIA. Carotid plaque imaging identifies high-risk patients who might be suited for inclusion into future secondary prevention trials. (Carotid Plaque Imaging in Acute Stroke [CAPIAS]; NCT01284933).CONCLUSIONSComplicated CAP ipsilateral to acute ischemic anterior circulation stroke are associated with an increased risk of recurrent ischemic stroke or TIA. Carotid plaque imaging identifies high-risk patients who might be suited for inclusion into future secondary prevention trials. (Carotid Plaque Imaging in Acute Stroke [CAPIAS]; NCT01284933). |
| Author | Cyran, Clemens C Helck, Andreas Harloff, Andreas Wollenweber, Frank A Sepp, Dominik Strecker, Christoph Dichgans, Martin Bayer-Karpinska, Anna Poli, Sven Malik, Rainer Koch, Mia L Saam, Tobias Schindler, Andreas Boeckh-Behrens, Tobias Poppert, Holger Zeller, Julia Janowitz, Daniel Kopczak, Anna Hempel, Johann-Martin Ziemann, Ulf |
| Author_xml | – sequence: 1 givenname: Anna surname: Kopczak fullname: Kopczak, Anna organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany – sequence: 2 givenname: Andreas surname: Schindler fullname: Schindler, Andreas organization: Department of Radiology, University Hospital, LMU Munich, Munich, Germany; Department of Neuroradiology, University Hospital, LMU Munich, Munich, Germany – sequence: 3 givenname: Dominik surname: Sepp fullname: Sepp, Dominik organization: Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany – sequence: 4 givenname: Anna surname: Bayer-Karpinska fullname: Bayer-Karpinska, Anna organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Klinikum Fürstenfeldbruck, Neurology, Fürstenfeldbruck, Germany – sequence: 5 givenname: Rainer surname: Malik fullname: Malik, Rainer organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany – sequence: 6 givenname: Mia L surname: Koch fullname: Koch, Mia L organization: Department of Neurology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany – sequence: 7 givenname: Julia surname: Zeller fullname: Zeller, Julia organization: Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany – sequence: 8 givenname: Christoph surname: Strecker fullname: Strecker, Christoph organization: Department of Neurology and Neurophysiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany – sequence: 9 givenname: Daniel surname: Janowitz fullname: Janowitz, Daniel organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany – sequence: 10 givenname: Frank A surname: Wollenweber fullname: Wollenweber, Frank A organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Department of Neurology, Helios Dr Horst-Schmidt-Kliniken, Wiesbaden, Germany – sequence: 11 givenname: Johann-Martin surname: Hempel fullname: Hempel, Johann-Martin organization: Department of Diagnostic and Interventional Neuroradiology, University of Tübingen, Tübingen, Germany – sequence: 12 givenname: Tobias surname: Boeckh-Behrens fullname: Boeckh-Behrens, Tobias organization: Department of Neuroradiology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany – sequence: 13 givenname: Clemens C surname: Cyran fullname: Cyran, Clemens C organization: Department of Radiology, University Hospital, LMU Munich, Munich, Germany – sequence: 14 givenname: Andreas surname: Helck fullname: Helck, Andreas organization: Radiology and Neuroradiology Zurich, Hirslanden/Klinik im Park, Zurich, Switzerland – sequence: 15 givenname: Andreas surname: Harloff fullname: Harloff, Andreas organization: Department of Neurology and Neurophysiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany – sequence: 16 givenname: Ulf surname: Ziemann fullname: Ziemann, Ulf organization: Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany – sequence: 17 givenname: Sven surname: Poli fullname: Poli, Sven organization: Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany – sequence: 18 givenname: Holger surname: Poppert fullname: Poppert, Holger organization: Department of Neurology, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Department of Neurology, Helios Klinikum München West, Munich, Germany – sequence: 19 givenname: Tobias surname: Saam fullname: Saam, Tobias organization: Department of Radiology, University Hospital, LMU Munich, Munich, Germany; Radiologisches Zentrum Rosenheim, Rosenheim, Germany – sequence: 20 givenname: Martin surname: Dichgans fullname: Dichgans, Martin email: martin.dichgans@med.uni-muenchen.de organization: Institute for Stroke and Dementia Research, University Hospital, LMU Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Electronic address: martin.dichgans@med.uni-muenchen.de |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35523659$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkDtPwzAYRS1URB_wBxiQR5YEP2LHHquIR6VKRaXM0RfHFmmTuNjJ0H8PiCIx3TscHV3dOZr0vrcI3VKSUkLlwz7dgzEpI4ylhKc8lxdoRoVQCRc6n_zrUzSPcU8IkYrqKzTlQjAuhZ6hTeG7Y9sYGGyNCwh-aGq8DIMNJ_zawudoI4a-xtsmHrB3eGvNGILtB7yK5sN2jcFvQ_AHi33Au9XyGl06aKO9OecCvT897oqXZL15XhXLdWJEzoakVoQKB4pBJl2ueSUqnYOUVjJHK2czLrjWKoNKAtXU0JpB7lgNWaYMzxxboPtf7zH4n5FD2TXR2LaF3voxlkxKSpRilH6jd2d0rDpbl8fQdBBO5d8J7Ausv2BU |
| CitedBy_id | crossref_primary_10_5551_jat_65397 crossref_primary_10_1016_j_eclinm_2025_103186 crossref_primary_10_1002_adfm_202214179 crossref_primary_10_1016_j_jocn_2025_111478 crossref_primary_10_1016_j_jcmg_2023_09_005 crossref_primary_10_1111_cns_70312 crossref_primary_10_1155_2023_5084699 crossref_primary_10_3389_fneur_2024_1340202 crossref_primary_10_1016_j_ejrad_2024_111497 crossref_primary_10_1016_j_jvssci_2025_100280 crossref_primary_10_1016_j_wneu_2023_10_054 crossref_primary_10_1177_15910199221150472 crossref_primary_10_3390_life14010073 crossref_primary_10_1161_STROKEAHA_122_041416 crossref_primary_10_1515_biol_2022_0722 crossref_primary_10_3174_ajnr_A8583 crossref_primary_10_3389_fcvm_2023_1177998 crossref_primary_10_1016_j_jstrokecerebrovasdis_2024_108020 crossref_primary_10_3390_diagnostics14161831 crossref_primary_10_1007_s40477_025_01002_1 crossref_primary_10_1093_cvr_cvad135 crossref_primary_10_1016_j_jacc_2022_04_004 crossref_primary_10_1016_j_cej_2024_158455 crossref_primary_10_1038_s41598_024_73584_5 crossref_primary_10_1007_s00062_023_01289_9 crossref_primary_10_1016_j_mri_2024_05_001 crossref_primary_10_1016_j_rcl_2023_01_006 crossref_primary_10_1161_STROKEAHA_124_049885 crossref_primary_10_1016_j_ejrad_2024_111547 crossref_primary_10_3389_fneur_2022_982896 crossref_primary_10_1016_j_jvs_2024_01_004 crossref_primary_10_14366_usg_24123 crossref_primary_10_1016_j_compmedimag_2025_102600 crossref_primary_10_1016_j_jacc_2023_01_002 crossref_primary_10_1186_s12880_025_01887_8 crossref_primary_10_2147_IJGM_S448852 crossref_primary_10_1055_a_1952_1159 crossref_primary_10_1161_STROKEAHA_124_046834 |
| ContentType | Journal Article |
| Copyright | Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.jacc.2022.03.376 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1558-3597 |
| ExternalDocumentID | 35523659 |
| Genre | Multicenter Study Journal Article |
| GroupedDBID | --- --K --M .1- .FO .~1 0R~ 18M 1B1 1P~ 1~. 1~5 2WC 4.4 457 4G. 53G 5GY 5RE 5VS 6PF 7-5 71M 8P~ AABNK AABVL AACTN AAEDT AAEDW AAIKJ AAKUH AALRI AAOAW AAQFI AAQQT AAXUO ABBQC ABFNM ABFRF ABLJU ABMAC ABMZM ABOCM ACGFO ACGFS ACIUM ACJTP ACPRK ADBBV ADEZE ADVLN AEFWE AEKER AENEX AEVXI AEXQZ AFCTW AFETI AFRAH AFRHN AFTJW AGYEJ AHMBA AITUG AJRQY AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ BAWUL BLXMC CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EO8 EO9 EP2 EP3 F5P FDB FEDTE FNPLU G-Q GBLVA GX1 HVGLF IHE IXB J1W K-O KQ8 L7B MO0 N9A NPM O-L O9- OA. OAUVE OK1 OL~ OZT P-8 P-9 P2P PC. PQQKQ Q38 ROL RPZ SCC SDF SDG SDP SES SSZ TR2 UNMZH UV1 W8F WH7 WOQ WOW YYM YZZ Z5R 7X8 ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP EFKBS ~HD |
| ID | FETCH-LOGICAL-c572t-d8015fa82a46f793b5b97a66e62f1bfe43539984ab6a191c1d2a7f2da448c34f2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 50 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000832974900003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1558-3597 |
| IngestDate | Mon Sep 29 06:38:23 EDT 2025 Thu Apr 03 07:08:29 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 22 |
| Keywords | carotid plaque MRI carotid artery intraplaque hemorrhage ischemic stroke stroke recurrence |
| Language | English |
| License | Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c572t-d8015fa82a46f793b5b97a66e62f1bfe43539984ab6a191c1d2a7f2da448c34f2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.clinicalkey.com/#!/content/1-s2.0-S0735109722046873 |
| PMID | 35523659 |
| PQID | 2661088211 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_2661088211 pubmed_primary_35523659 |
| PublicationCentury | 2000 |
| PublicationDate | 2022-06-07 |
| PublicationDateYYYYMMDD | 2022-06-07 |
| PublicationDate_xml | – month: 06 year: 2022 text: 2022-06-07 day: 07 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of the American College of Cardiology |
| PublicationTitleAlternate | J Am Coll Cardiol |
| PublicationYear | 2022 |
| SSID | ssj0006819 |
| Score | 2.5763648 |
| Snippet | Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.
The purpose of this study was to determine whether complicated... Complicated nonstenosing carotid artery plaques (CAPs) are an under-recognized cause of stroke.BACKGROUNDComplicated nonstenosing carotid artery plaques (CAPs)... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 2189 |
| SubjectTerms | Carotid Arteries - pathology Carotid Stenosis - complications Carotid Stenosis - diagnostic imaging Carotid Stenosis - epidemiology Humans Ischemic Attack, Transient - epidemiology Ischemic Attack, Transient - etiology Ischemic Stroke Plaque, Atherosclerotic - complications Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - pathology Risk Factors Stroke - diagnosis Stroke - epidemiology Stroke - etiology |
| Title | Complicated Carotid Artery Plaques and Risk of Recurrent Ischemic Stroke or TIA |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35523659 https://www.proquest.com/docview/2661088211 |
| Volume | 79 |
| WOSCitedRecordID | wos000832974900003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEF7Uinjx_agvVvC6aDbJJnuSUiz20Fpqhd7CPqGtJDWJgv_e2SSlJ0HwkkMeZJmd3flm5tsZhO6k9qkVVhFP0pAEUnIilAoI4wEzVFJPUFU1m4iGw3g65aMm4FY0tMrVnlht1DpTLkZ-7wyJg4Oe97j8IK5rlMuuNi00NlHLByjjtDqarquFs7hq7AEmMyY-IOfm0EzN75rDmMA_pNQVOfUj9jvErExNb_-_gzxAew3IxJ1aKw7RhkmP0M6gSaMfo5fuikhuNHaUj3Km3dsm_8ajd-H-iEWq8XhWLHBm8dgF5V0ZJ9wHZ9jR6fFrmWcLg7McT_qdE_TWe5p0n0nTWYGoMKIl0WCXQitiKgJmYYXKUPJIMGYYtZ60BjAUSDMOhGQCHDrlaSoiS7UAZ075gaWnaCvNUnOOcAi3A18rruCpeJCcwuwLbrxQSXCXZBvdrkSVgOa6dIRITfZZJGthtdFZLe9kWZfYSAAFUZ-F_OIPX1-iXTeNFX8rukItC-vWXKNt9VXOivymUgm4DkeDH_3wwH0 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Complicated+Carotid+Artery+Plaques+and+Risk+of+Recurrent+Ischemic+Stroke+or+TIA&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.au=Kopczak%2C+Anna&rft.au=Schindler%2C+Andreas&rft.au=Sepp%2C+Dominik&rft.au=Bayer-Karpinska%2C+Anna&rft.date=2022-06-07&rft.eissn=1558-3597&rft.volume=79&rft.issue=22&rft.spage=2189&rft_id=info:doi/10.1016%2Fj.jacc.2022.03.376&rft_id=info%3Apmid%2F35523659&rft_id=info%3Apmid%2F35523659&rft.externalDocID=35523659 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1558-3597&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1558-3597&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1558-3597&client=summon |