Traits, phylogeny and host cell receptors predict Ebolavirus host status among African mammals
We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from Ebolavirus after exposure and infection status based on PCR and antibody tests. We performed ridge regre...
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| Published in: | PLoS neglected tropical diseases Vol. 16; no. 12; p. e0010993 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
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Public Library of Science
21.12.2022
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| ISSN: | 1935-2735, 1935-2727, 1935-2735 |
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| Abstract | We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from
Ebolavirus
after exposure and infection status based on PCR and antibody tests. We performed ridge regressions predicting mortality and infection as a function of traits, phylogenetic eigenvectors and separately host receptor sequences. We found that mortality from
Ebolavirus
had a strong association to life history characteristics and phylogeny. In contrast, infection status related not just to life history and phylogeny, but also to fruit consumption which suggests that geographic overlap of frugivorous mammals can lead to spread of virus in the wild. Niemann Pick C1 (NPC1) receptor sequences predicted infection statuses of bats included in our study with very high accuracy, suggesting that characterizing NPC1 in additional species is a promising avenue for future work. We combine the predictions from our mortality and infection status models to differentiate between species that are infected and also die from
Ebolavirus
versus species that are infected but tolerate the virus (possible reservoirs of
Ebolavirus
). We therefore present the first comprehensive estimates of
Ebolavirus
reservoir statuses for all known terrestrial mammals in Africa. |
|---|---|
| AbstractList | We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from Ebolavirus after exposure and infection status based on PCR and antibody tests. We performed ridge regressions predicting mortality and infection as a function of traits, phylogenetic eigenvectors and separately host receptor sequences. We found that mortality from Ebolavirus had a strong association to life history characteristics and phylogeny. In contrast, infection status related not just to life history and phylogeny, but also to fruit consumption which suggests that geographic overlap of frugivorous mammals can lead to spread of virus in the wild. Niemann Pick C1 (NPC1) receptor sequences predicted infection statuses of bats included in our study with very high accuracy, suggesting that characterizing NPC1 in additional species is a promising avenue for future work. We combine the predictions from our mortality and infection status models to differentiate between species that are infected and also die from Ebolavirus versus species that are infected but tolerate the virus (possible reservoirs of Ebolavirus). We therefore present the first comprehensive estimates of Ebolavirus reservoir statuses for all known terrestrial mammals in Africa. We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from Ebolavirus after exposure and infection status based on PCR and antibody tests. We performed ridge regressions predicting mortality and infection as a function of traits, phylogenetic eigenvectors and separately host receptor sequences. We found that mortality from Ebolavirus had a strong association to life history characteristics and phylogeny. In contrast, infection status related not just to life history and phylogeny, but also to fruit consumption which suggests that geographic overlap of frugivorous mammals can lead to spread of virus in the wild. Niemann Pick C1 (NPC1) receptor sequences predicted infection statuses of bats included in our study with very high accuracy, suggesting that characterizing NPC1 in additional species is a promising avenue for future work. We combine the predictions from our mortality and infection status models to differentiate between species that are infected and also die from Ebolavirus versus species that are infected but tolerate the virus (possible reservoirs of Ebolavirus). We therefore present the first comprehensive estimates of Ebolavirus reservoir statuses for all known terrestrial mammals in Africa. Identifying the animal hosts of Ebolavirus is crucial to preventing future outbreaks. We gathered exhaustive databases of which species die and which species show evidence of past infection from ebolaviruses in published literature. Our approach allowed us to differentiate which species show high mortality from Ebolavirus and which species tolerate the infection after exposure. We found that fruit bats are likely reservoirs as they are exposed to the infection but tolerate the virus, whereas primates do not serve as ideal reservoirs because they succumb to the infection once exposed. We also compared different predictors of infection and conclude that receptors of Ebolavirus best predict infection in bats whereas ecological traits predict infection in primates. We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from Ebolavirus after exposure and infection status based on PCR and antibody tests. We performed ridge regressions predicting mortality and infection as a function of traits, phylogenetic eigenvectors and separately host receptor sequences. We found that mortality from Ebolavirus had a strong association to life history characteristics and phylogeny. In contrast, infection status related not just to life history and phylogeny, but also to fruit consumption which suggests that geographic overlap of frugivorous mammals can lead to spread of virus in the wild. Niemann Pick C1 (NPC1) receptor sequences predicted infection statuses of bats included in our study with very high accuracy, suggesting that characterizing NPC1 in additional species is a promising avenue for future work. We combine the predictions from our mortality and infection status models to differentiate between species that are infected and also die from Ebolavirus versus species that are infected but tolerate the virus (possible reservoirs of Ebolavirus ). We therefore present the first comprehensive estimates of Ebolavirus reservoir statuses for all known terrestrial mammals in Africa. We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from Ebolavirus after exposure and infection status based on PCR and antibody tests. We performed ridge regressions predicting mortality and infection as a function of traits, phylogenetic eigenvectors and separately host receptor sequences. We found that mortality from Ebolavirus had a strong association to life history characteristics and phylogeny. In contrast, infection status related not just to life history and phylogeny, but also to fruit consumption which suggests that geographic overlap of frugivorous mammals can lead to spread of virus in the wild. Niemann Pick C1 (NPC1) receptor sequences predicted infection statuses of bats included in our study with very high accuracy, suggesting that characterizing NPC1 in additional species is a promising avenue for future work. We combine the predictions from our mortality and infection status models to differentiate between species that are infected and also die from Ebolavirus versus species that are infected but tolerate the virus (possible reservoirs of Ebolavirus). We therefore present the first comprehensive estimates of Ebolavirus reservoir statuses for all known terrestrial mammals in Africa.We explore how animal host traits, phylogenetic identity and cell receptor sequences relate to infection status and mortality from ebolaviruses. We gathered exhaustive databases of mortality from Ebolavirus after exposure and infection status based on PCR and antibody tests. We performed ridge regressions predicting mortality and infection as a function of traits, phylogenetic eigenvectors and separately host receptor sequences. We found that mortality from Ebolavirus had a strong association to life history characteristics and phylogeny. In contrast, infection status related not just to life history and phylogeny, but also to fruit consumption which suggests that geographic overlap of frugivorous mammals can lead to spread of virus in the wild. Niemann Pick C1 (NPC1) receptor sequences predicted infection statuses of bats included in our study with very high accuracy, suggesting that characterizing NPC1 in additional species is a promising avenue for future work. We combine the predictions from our mortality and infection status models to differentiate between species that are infected and also die from Ebolavirus versus species that are infected but tolerate the virus (possible reservoirs of Ebolavirus). We therefore present the first comprehensive estimates of Ebolavirus reservoir statuses for all known terrestrial mammals in Africa. |
| Audience | Academic |
| Author | Sundaram, Mekala Schmidt, John Paul Drake, John M. Stephens, Patrick R. Han, Barbara A. |
| AuthorAffiliation | 2 Odum School of Ecology, University of Georgia, Athens, Georgia, United States of America 1 Department of Integrative Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America University of Texas Medical Branch / Galveston National Laboratory, UNITED STATES 4 Center for the Ecology of Infectious Diseases, University of Georgia, Athens, Georgia, United States of America 3 Cary Institute of Ecosystems Studies, Millbrook, New York, United States of America |
| AuthorAffiliation_xml | – name: University of Texas Medical Branch / Galveston National Laboratory, UNITED STATES – name: 1 Department of Integrative Biology, Oklahoma State University, Stillwater, Oklahoma, United States of America – name: 4 Center for the Ecology of Infectious Diseases, University of Georgia, Athens, Georgia, United States of America – name: 3 Cary Institute of Ecosystems Studies, Millbrook, New York, United States of America – name: 2 Odum School of Ecology, University of Georgia, Athens, Georgia, United States of America |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36542657$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1099/jgv.0.000999 10.1111/1365-2656.12160 10.3201/eid1102.040533 10.1093/nar/gks1195 10.1016/j.virol.2014.08.019 10.1038/438575a 10.1086/514304 10.1093/infdis/jiv063 10.1016/S1286-4579(99)00242-7 10.1016/j.celrep.2019.12.042 10.1111/j.1523-1739.2010.01455.x 10.1016/j.bbalip.2004.08.006 10.1098/rstb.2018.0337 10.3201/eid1012.040346 10.1371/journal.ppat.1000536 10.1086/514290 10.1111/j.1600-0706.2012.020215.x 10.1111/1365-2656.12987 10.1016/j.trstmh.2006.07.002 10.1093/bioinformatics/btm076 10.1002/ecy.3344 10.1186/1471-2148-10-193 10.1007/s004399900059 10.1016/j.micinf.2005.04.006 10.1080/00401706.1993.10485033 10.1073/pnas.0704076104 10.1098/rspb.2005.3155 10.1111/j.1461-0248.2012.01858.x 10.1093/icb/icl049 10.1086/514299 10.1126/science.1133105 10.1016/j.tim.2007.08.001 10.1093/bioinformatics/btu531 10.1371/journal.ppat.1002877 10.1089/vbz.2008.0167 10.1128/mSphere.00007-16 10.1073/pnas.90.5.2002 10.1086/514296 10.1111/mam.12074 10.1007/s12035-019-1528-z 10.3201/eid2412.180740 10.1186/1471-2105-12-372 10.15252/emmm.201404792 10.3201/eid2303.160101 10.1073/pnas.1019140108 10.1534/genetics.105.046565 10.1007/82_2017_20 10.1007/82_2017_10 10.1126/science.1092528 10.1086/514278 10.3390/v7072779 10.1111/j.1469-7998.1990.tb04316.x 10.3389/fimmu.2017.01098 10.1002/gepi.21750 10.7589/2014-08-198 10.3201/eid0204.960407 10.1194/jlr.M700525-JLR200 10.1093/infdis/jiz007 10.3390/v10100549 |
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| References | World Health Organization (pntd.0010993.ref005) 2005; 80 P Reiter (pntd.0010993.ref007) 1999; 179 RS Bennett (pntd.0010993.ref059) 2017 H Ogawa (pntd.0010993.ref061) 2015; 212 BI Tieleman (pntd.0010993.ref054) 2005; 272 E Cule (pntd.0010993.ref044) 2011; 12 P Rouquet (pntd.0010993.ref072) 2005; 11 MEB Jones (pntd.0010993.ref066) 2015; 7 JP Schmidt (pntd.0010993.ref039) 2017; 23 AP Tu-Chan (pntd.0010993.ref047) 2017; 14 EM Leroy (pntd.0010993.ref068) 2005; 438 E Cule (pntd.0010993.ref045) 2013; 37 MA Previtali (pntd.0010993.ref055) 2012; 121 KA Lee (pntd.0010993.ref053) 2006; 46 EM Leroy (pntd.0010993.ref073) 2004; 303 PR Stephens (pntd.0010993.ref023) 2019; 88 EM Leroy (pntd.0010993.ref002) 2009; 9 R Ricklefs (pntd.0010993.ref052) 2002; 17 A Groseth (pntd.0010993.ref009) 2007; 15 A Caron (pntd.0010993.ref017) 2018; 10 NS Upham (pntd.0010993.ref040) 2019 ML Fluegel (pntd.0010993.ref033) 2006; 172 N Cooper (pntd.0010993.ref021) 2012; 15 R Swanepoel (pntd.0010993.ref025) 1996; 2 M Ng (pntd.0010993.ref027) 2015; 4 M Bermejo (pntd.0010993.ref013) 2006; 314 RA Barton (pntd.0010993.ref038) 2011; 108 TT Peterson (pntd.0010993.ref018) 2004; 10 DE Promislow (pntd.0010993.ref051) 1990; 220 H Leirs (pntd.0010993.ref010) 1999; 179 BR Amman (pntd.0010993.ref011) 2017 DA Benson (pntd.0010993.ref036) 2013; 41 SA Lahm (pntd.0010993.ref004) 2007; 101 Y Takadate (pntd.0010993.ref026) 2020; 30 JP Schmidt (pntd.0010993.ref019) 2019; 374 AJ Georges (pntd.0010993.ref012) 1999; 179 T Santos (pntd.0010993.ref041) 2012 AD Jayaprakash (pntd.0010993.ref057) 2021 JH Kuhn (pntd.0010993.ref001) 2008 TJ Wittmann (pntd.0010993.ref071) 2007; 104 BA Han (pntd.0010993.ref020) 2016; 10 SA Fritz (pntd.0010993.ref042) 2010; 24 HM De Nys (pntd.0010993.ref062) 2018; 24 T Yamamoto (pntd.0010993.ref031) 1999; 105 DTS Hayman (pntd.0010993.ref015) 2019; 220 DTS Hayman (pntd.0010993.ref060) 2010; 5 E Ndungo (pntd.0010993.ref028) 2016; 1 Commission M of the I (pntd.0010993.ref016) 1978; 56 X Pourrut (pntd.0010993.ref003) 2005; 7 AK Abbas (pntd.0010993.ref058) 2022 JS Papadopoulos (pntd.0010993.ref049) 2007; 23 JS Towner (pntd.0010993.ref063) 2009; 5 P Formenty (pntd.0010993.ref014) 1999; 179 M Ng (pntd.0010993.ref030) 2014; 0 BR Amman (pntd.0010993.ref065) 2015; 51 JG Breman (pntd.0010993.ref008) 1999; 179 DJ Taylor (pntd.0010993.ref069) 2010; 10 ED Carstea (pntd.0010993.ref029) 1993; 90 MD Ugarte (pntd.0010993.ref048) 2016 CD Soria (pntd.0010993.ref037) 2021; 102 LE Frank (pntd.0010993.ref043) 1993; 35 J Olivero (pntd.0010993.ref024) 2017; 47 S Moritz (pntd.0010993.ref046) 2022 BR Amman (pntd.0010993.ref064) 2012; 8 JM Morvan (pntd.0010993.ref070) 1999; 1 A. Larsson (pntd.0010993.ref050) 2014; 30 B Liu (pntd.0010993.ref034) 2008; 49 S Huang (pntd.0010993.ref022) 2014; 83 Y Kurosaki (pntd.0010993.ref067) 2018; 99 AM Saéz (pntd.0010993.ref006) 2015; 7 C Scott (pntd.0010993.ref032) 2004; 1685 T Schountz (pntd.0010993.ref056) 2017; 8 M Polese-Bonatto (pntd.0010993.ref035) 2019; 56 |
| References_xml | – volume: 14 start-page: 1 year: 2017 ident: pntd.0010993.ref047 article-title: Effects of somatosensory electrical stimulation on motor function and cortical oscillations publication-title: J. Neuroeng. Rehabilitation – volume: 99 start-page: 181 year: 2018 ident: pntd.0010993.ref067 article-title: Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species publication-title: J Gen Virol doi: 10.1099/jgv.0.000999 – volume: 83 start-page: 671 year: 2014 ident: pntd.0010993.ref022 article-title: Phylogenetically related and ecologically similar carnivores harbour similar parasite assemblages publication-title: J Anim Ecol doi: 10.1111/1365-2656.12160 – volume: 11 start-page: 283 year: 2005 ident: pntd.0010993.ref072 article-title: Wild animal mortality monitoring and human ebola outbreaks, Gabon and Republic of Congo, 2001–2003 publication-title: Emerg Infect Dis doi: 10.3201/eid1102.040533 – volume: 41 start-page: 36 year: 2013 ident: pntd.0010993.ref036 article-title: GenBank publication-title: Nucleic Acids Res doi: 10.1093/nar/gks1195 – volume: 0 start-page: 637 year: 2014 ident: pntd.0010993.ref030 article-title: Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1 publication-title: Virology doi: 10.1016/j.virol.2014.08.019 – volume: 438 start-page: 575 year: 2005 ident: pntd.0010993.ref068 article-title: Fruit bats as reservoirs of Ebola virus publication-title: Nature doi: 10.1038/438575a – volume: 4 start-page: 1 year: 2015 ident: pntd.0010993.ref027 article-title: Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats publication-title: Elife – volume: 179 start-page: 148 year: 1999 ident: pntd.0010993.ref007 article-title: Field investigations of an outbreak of Ebola hemorrhagic fever, Kikwit, Democratic Republic of the Congo, 1995: Arthropod studies publication-title: J Infect Dis doi: 10.1086/514304 – volume: 212 start-page: S101 year: 2015 ident: pntd.0010993.ref061 article-title: Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum) Migrating in Africa publication-title: J Infect Dis doi: 10.1093/infdis/jiv063 – volume: 1 start-page: 1193 year: 1999 ident: pntd.0010993.ref070 article-title: Identification of Ebola virus sequences present as RNA or DNA in organs of terrestrial small mammals of the Central African Republic publication-title: Microbes Infect doi: 10.1016/S1286-4579(99)00242-7 – volume: 30 start-page: 308 year: 2020 ident: pntd.0010993.ref026 article-title: Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism publication-title: Cell Rep doi: 10.1016/j.celrep.2019.12.042 – volume: 24 start-page: 1042 year: 2010 ident: pntd.0010993.ref042 article-title: Selectivity in mammalian extinction risk and threat types: A new measure of phylogenetic signal strength in binary traits publication-title: Conserv Biol doi: 10.1111/j.1523-1739.2010.01455.x – volume-title: Probability and statistics with R year: 2016 ident: pntd.0010993.ref048 – volume: 1685 start-page: 8 year: 2004 ident: pntd.0010993.ref032 article-title: The NPC1 protein: Structure implies function publication-title: Biochim Biophys Acta—Mol Cell Biol Lipids doi: 10.1016/j.bbalip.2004.08.006 – volume: 374 year: 2019 ident: pntd.0010993.ref019 article-title: Ecological indicators of mammal exposure to Ebolavirus publication-title: Philos Trans R Soc B Biol Sci doi: 10.1098/rstb.2018.0337 – volume: 10 start-page: 2073 year: 2004 ident: pntd.0010993.ref018 article-title: Potential mammalian filovirus reservoirs publication-title: Emerg Infect Dis doi: 10.3201/eid1012.040346 – volume: 5 year: 2009 ident: pntd.0010993.ref063 article-title: Isolation of genetically diverse Marburg viruses from Egyptian fruit bats publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1000536 – volume: 179 start-page: 1994 year: 1999 ident: pntd.0010993.ref012 article-title: Ebola hemorrhagic fever outbreaks in Gabon, 1994–1997: Epidemiologic and health control issues publication-title: J Infect Dis doi: 10.1086/514290 – volume: 121 start-page: 1483 year: 2012 ident: pntd.0010993.ref055 article-title: Relationship between pace of life and immune responses in wild rodents publication-title: Oikos doi: 10.1111/j.1600-0706.2012.020215.x – volume: 88 start-page: 1017 year: 2019 ident: pntd.0010993.ref023 article-title: Parasite sharing in wild ungulates and their predators: Effects of phylogeny, range overlap, and trophic links publication-title: J Anim Ecol doi: 10.1111/1365-2656.12987 – volume: 10 start-page: 1 year: 2016 ident: pntd.0010993.ref020 article-title: Undiscovered Bat Hosts of Filoviruses publication-title: PLoS Negl Trop Dis – year: 2021 ident: pntd.0010993.ref057 article-title: Marburg and Ebola virus infections elicit a muted inflammatory state in bats publication-title: bioRxiv – volume: 101 start-page: 64 year: 2007 ident: pntd.0010993.ref004 article-title: Morbidity and mortality of wild animals in relation to outbreaks of Ebola haemorrhagic fever in Gabon, 1994–2003 publication-title: Trans R Soc Trop Med Hyg doi: 10.1016/j.trstmh.2006.07.002 – volume: 23 start-page: 1073 year: 2007 ident: pntd.0010993.ref049 article-title: COBALT: Constraint-based alignment tool for multiple protein sequences publication-title: Bioinformatics doi: 10.1093/bioinformatics/btm076 – volume: 102 start-page: 13028255 year: 2021 ident: pntd.0010993.ref037 article-title: COMBINE: a coalesced mammal database of intrinsic and extrinsic traits publication-title: Ecology doi: 10.1002/ecy.3344 – volume: 10 year: 2010 ident: pntd.0010993.ref069 article-title: Filoviruses are ancient and integrated into mammalian genomes publication-title: BMC Evol Biol doi: 10.1186/1471-2148-10-193 – volume: 105 start-page: 10 year: 1999 ident: pntd.0010993.ref031 article-title: NPC1 gene mutations in Japanese patients with Niemann-Pick disease type C publication-title: Hum Genet doi: 10.1007/s004399900059 – volume: 7 start-page: 1005 year: 2005 ident: pntd.0010993.ref003 article-title: The natural history of Ebola virus in Africa publication-title: Microbes Infect doi: 10.1016/j.micinf.2005.04.006 – volume: 35 start-page: 109 year: 1993 ident: pntd.0010993.ref043 article-title: A statistical view of some chemometrics regression tools publication-title: Technometrics doi: 10.1080/00401706.1993.10485033 – volume-title: Filoviruses: a compendium of 40 years of epidemiological, clinical, and laboratory studies year: 2008 ident: pntd.0010993.ref001 – volume: 56 start-page: 271 year: 1978 ident: pntd.0010993.ref016 article-title: Ebola haemorrhagic fever in Zaire, 1976. Report of an international commission publication-title: Bull World Health Organ – volume: 104 start-page: 19656 year: 2007 ident: pntd.0010993.ref071 article-title: Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0704076104 – volume: 272 start-page: 1715 year: 2005 ident: pntd.0010993.ref054 article-title: Constitutive innate immunity is a component of the pace-of-life syndrome in tropical birds publication-title: Proc R Soc B-Biological Sci doi: 10.1098/rspb.2005.3155 – volume: 15 start-page: 1370 year: 2012 ident: pntd.0010993.ref021 article-title: Phylogenetic host specificity and understanding parasite sharing in primates publication-title: Ecol Lett doi: 10.1111/j.1461-0248.2012.01858.x – volume: 46 start-page: 1000 year: 2006 ident: pntd.0010993.ref053 article-title: Linking immune defenses and life history at the levels of the individual and the species publication-title: Integr Comp Biol doi: 10.1093/icb/icl049 – volume: 179 start-page: 155 year: 1999 ident: pntd.0010993.ref010 article-title: Search for the Ebola virus reservoir in Kikwit, Democratic Republic of the Congo: Reflections on a vertebrate collection publication-title: J Infect Dis doi: 10.1086/514299 – volume: 314 start-page: 1564 year: 2006 ident: pntd.0010993.ref013 article-title: Ebola outbreak killed 5000 gorillas publication-title: Science doi: 10.1126/science.1133105 – volume: 15 start-page: 408 year: 2007 ident: pntd.0010993.ref009 article-title: The ecology of Ebola virus publication-title: Trends Microbiol doi: 10.1016/j.tim.2007.08.001 – volume: 30 start-page: 3276 year: 2014 ident: pntd.0010993.ref050 article-title: AliView: A fast and lightweight alignment viewer and editor for large datasets publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu531 – volume: 8 year: 2012 ident: pntd.0010993.ref064 article-title: Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1002877 – start-page: 1 year: 2012 ident: pntd.0010993.ref041 article-title: Package “PVR.” – volume: 9 start-page: 723 year: 2009 ident: pntd.0010993.ref002 article-title: Human ebola outbreak resulting from direct exposure to fruit bats in Luebo, Democratic Republic of Congo, 2007 publication-title: Vector-Borne Zoonotic Dis doi: 10.1089/vbz.2008.0167 – volume: 1 start-page: 1 year: 2016 ident: pntd.0010993.ref028 article-title: A single residue in Ebola virus receptor NPC1 influences cellular host range in reptiles publication-title: mSphere doi: 10.1128/mSphere.00007-16 – volume: 90 start-page: 2002 year: 1993 ident: pntd.0010993.ref029 article-title: Linkage of Niemann-Pick disease Type-C to human chromosome-18 publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.90.5.2002 – volume-title: Cellular and molecular immunology E-book year: 2022 ident: pntd.0010993.ref058 – volume: 80 start-page: 370 year: 2005 ident: pntd.0010993.ref005 article-title: Outbreak of Ebola haemorrhagic fever in Yambio, south Sudan, April—June 2004 publication-title: Wkly Epidemiol Rec – volume: 179 start-page: 120 year: 1999 ident: pntd.0010993.ref014 article-title: Ebola virus outbreak among wild chimpanzees living in a rain forest of Cote d’Ivoire publication-title: J Infect Dis doi: 10.1086/514296 – volume: 47 start-page: 24 year: 2017 ident: pntd.0010993.ref024 article-title: Mammalian biogeography and the Ebola virus in Africa publication-title: Mamm Rev doi: 10.1111/mam.12074 – volume: 56 start-page: 6426 year: 2019 ident: pntd.0010993.ref035 article-title: Niemann-Pick Disease Type C: Mutation Spectrum and Novel Sequence Variations in the Human NPC1 Gene publication-title: Mol Neurobiol doi: 10.1007/s12035-019-1528-z – volume: 24 start-page: 2228 year: 2018 ident: pntd.0010993.ref062 article-title: Survey of ebola viruses in frugivorous and insectivorous bats in Guinea, Cameroon, and the democratic republic of the Congo, 2015–2017 publication-title: Emerg Infect Dis doi: 10.3201/eid2412.180740 – volume: 12 year: 2011 ident: pntd.0010993.ref044 article-title: Significance testing in ridge regression for genetic data publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-12-372 – volume: 7 start-page: 17 year: 2015 ident: pntd.0010993.ref006 article-title: Investigating the zoonotic origin of the West African Ebola epidemic publication-title: EMBO Mol Med doi: 10.15252/emmm.201404792 – volume: 23 start-page: 415 year: 2017 ident: pntd.0010993.ref039 article-title: Spatiotemporal fluctuations and triggers of ebola virus spillover publication-title: Emerg Infect Dis doi: 10.3201/eid2303.160101 – volume-title: ridge: Ridge regression with automatic selection of the penalty parameter year: 2022 ident: pntd.0010993.ref046 – volume: 108 start-page: 6169 year: 2011 ident: pntd.0010993.ref038 article-title: Maternal investment, life histories, and the costs of brain growth in mammals publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1019140108 – volume: 172 start-page: 185 year: 2006 ident: pntd.0010993.ref033 article-title: Mutations of a drosophila NPC1 gene confer sterol and ecdysone metabolic defects publication-title: Genetics doi: 10.1534/genetics.105.046565 – start-page: 171 volume-title: Ebolaviruses From Ecosysems to Molecules. year: 2017 ident: pntd.0010993.ref059 doi: 10.1007/82_2017_20 – start-page: 23 volume-title: Marburg- and Ebolaviruses From Ecosysems to Molecules year: 2017 ident: pntd.0010993.ref011 doi: 10.1007/82_2017_10 – volume: 5 start-page: 2008 year: 2010 ident: pntd.0010993.ref060 article-title: Long-term survival of an urban fruit bat seropositive for ebola and lagos bat viruses publication-title: PLoS One – volume: 303 start-page: 387 year: 2004 ident: pntd.0010993.ref073 article-title: Multiple Ebola Virus Transmission Events and Rapid Decline of Central African Wildlife publication-title: Science doi: 10.1126/science.1092528 – year: 2019 ident: pntd.0010993.ref040 article-title: Inferring the mammal tree: Species-level sets of phylogenies for questions in ecology, evolution, and conservation publication-title: PLoS Biology – volume: 179 start-page: 1979 year: 1999 ident: pntd.0010993.ref008 article-title: A search for Ebola virus in animals in the Democratic Republic of the Congo and Cameroon: Ecologic, virologic, and serologic surveys, 1979–1980 publication-title: J Infect Dis doi: 10.1086/514278 – volume: 17 start-page: 462 year: 2002 ident: pntd.0010993.ref052 article-title: Biodiversity reflects in part the diversification of life histories publication-title: Trends Ecol Evol – volume: 7 start-page: 3420 year: 2015 ident: pntd.0010993.ref066 article-title: Experimental inoculation of egyptian rousette bats (Rousettus aegyptiacus) with viruses of the ebolavirus and marburgvirus genera publication-title: Viruses doi: 10.3390/v7072779 – volume: 220 start-page: 417 year: 1990 ident: pntd.0010993.ref051 article-title: Living fast and dying young: a comparative analysis of life-history variation among mammals publication-title: J Zool doi: 10.1111/j.1469-7998.1990.tb04316.x – volume: 8 start-page: 1098 year: 2017 ident: pntd.0010993.ref056 article-title: Immunological control of viral infections in bats and the emergence of viruses highly pathogenic to humans publication-title: Front Immunol doi: 10.3389/fimmu.2017.01098 – volume: 37 start-page: 704 year: 2013 ident: pntd.0010993.ref045 article-title: Ridge regression in prediction problems: Automatic choice of the ridge parameter publication-title: Genet Epidemiol doi: 10.1002/gepi.21750 – volume: 51 start-page: 113 year: 2015 ident: pntd.0010993.ref065 article-title: Oral shedding of Marburg virus in experimentally infected Egyptian fruit bats (Rousettus aegyptiacus) publication-title: J Wildl Dis doi: 10.7589/2014-08-198 – volume: 2 start-page: 321 year: 1996 ident: pntd.0010993.ref025 article-title: Experimental Inoculation of Plants and Animals with Ebola Virus publication-title: Emerg Infect Dis doi: 10.3201/eid0204.960407 – volume: 49 start-page: 663 year: 2008 ident: pntd.0010993.ref034 article-title: Genetic variations and treatments that affect the lifespan of the NPC1 mouse publication-title: J Lipid Res doi: 10.1194/jlr.M700525-JLR200 – volume: 220 start-page: 1547 year: 2019 ident: pntd.0010993.ref015 article-title: African Primates: Likely Victims, Not Reservoirs, of Ebolaviruses publication-title: J Infect Dis doi: 10.1093/infdis/jiz007 – volume: 10 year: 2018 ident: pntd.0010993.ref017 article-title: Ebola virus maintenance: if not (Only) bats, what else? publication-title: Viruses doi: 10.3390/v10100549 |
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| Title | Traits, phylogeny and host cell receptors predict Ebolavirus host status among African mammals |
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