MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking

Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expre...

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Bibliographic Details
Published in:	Tuberculosis (Edinburgh, Scotland) Vol. 95; no. 1; pp. 60 - 67
Main Authors:	Vegh, Peter, Magee, David A., Nalpas, Nicolas C., Bryan, Kenneth, McCabe, Matthew S., Browne, John A., Conlon, Kevin M., Gordon, Stephen V., Bradley, Daniel G., MacHugh, David E., Lynn, David J.
Format:	Journal Article
Language:	English
Published:	Scotland Elsevier Ltd 01.01.2015
Subjects:	Alveolar macrophage Animals Bos taurus Cattle Cells, Cultured Down-Regulation Endocytosis - immunology Gene Expression - genetics Gene Expression - immunology Gene Expression Profiling - methods Immunity, Innate - immunology Infectious Disease Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors Lysosomes - immunology Macrophages, Alveolar - immunology Male microRNA MicroRNAs - genetics MicroRNAs - immunology MicroRNAs - physiology Mycobacterium bovis Mycobacterium bovis - immunology Pulmonary/Respiratory Real-Time Polymerase Chain Reaction - methods RNA, Bacterial - genetics RNA, Bacterial - immunology RNA-seq Sequence Analysis, RNA - methods Transfection - methods Transforming Growth Factor beta2 - antagonists & inhibitors Tuberculosis Tuberculosis, Bovine - immunology Tuberculosis, Pulmonary - immunology Up-Regulation microRNA Tuberculosis Bos taurus RNA-seq Mycobacterium bovis Alveolar macrophage
ISSN:	1472-9792, 1873-281X, 1873-281X
Online Access:	Get full text
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