MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking
Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expre...
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| Published in: | Tuberculosis (Edinburgh, Scotland) Vol. 95; no. 1; pp. 60 - 67 |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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01.01.2015
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| ISSN: | 1472-9792, 1873-281X, 1873-281X |
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| Abstract | Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expression in primary bovine AMs post-infection with M. bovis. One, six, and forty miRNAs were identified as significantly differentially expressed at 2, 24 and 48 h post-infection, respectively. The differential expression of three miRNAs (bta-miR-142-5p, bta-miR-146a, and bta-miR-423-3p) was confirmed by RT-qPCR. Pathway analysis of the predicted mRNA targets of differentially expressed miRNAs suggests that these miRNAs preferentially target several pathways that are functionally relevant for mycobacterial pathogenesis, including endocytosis and lysosome trafficking, IL-1 signalling and the TGF-β pathway. Over-expression studies using a bovine macrophage cell-line (Bomac) reveal the targeting of two key genes in the innate immune response to M. bovis, IL-1 receptor-associated kinase 1 (IRAK1) and TGF-β receptor 2 (TGFBR2), by miR-146. Taken together, our study suggests that miRNAs play a key role in tuning the complex interplay between M. bovis survival strategies and the host immune response. |
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| AbstractList | Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expression in primary bovine AMs post-infection with M. bovis. One, six, and forty miRNAs were identified as significantly differentially expressed at 2, 24 and 48 h post-infection, respectively. The differential expression of three miRNAs (bta-miR-142-5p, bta-miR-146a, and bta-miR-423-3p) was confirmed by RT-qPCR. Pathway analysis of the predicted mRNA targets of differentially expressed miRNAs suggests that these miRNAs preferentially target several pathways that are functionally relevant for mycobacterial pathogenesis, including endocytosis and lysosome trafficking, IL-1 signalling and the TGF-β pathway. Over-expression studies using a bovine macrophage cell-line (Bomac) reveal the targeting of two key genes in the innate immune response to M. bovis, IL-1 receptor-associated kinase 1 (IRAK1) and TGF-β receptor 2 (TGFBR2), by miR-146. Taken together, our study suggests that miRNAs play a key role in tuning the complex interplay between M. bovis survival strategies and the host immune response. Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expression in primary bovine AMs post-infection with M. bovis. One, six, and forty miRNAs were identified as significantly differentially expressed at 2, 24 and 48 h post-infection, respectively. The differential expression of three miRNAs (bta-miR-142-5p, bta-miR-146a, and bta-miR-423-3p) was confirmed by RT-qPCR. Pathway analysis of the predicted mRNA targets of differentially expressed miRNAs suggests that these miRNAs preferentially target several pathways that are functionally relevant for mycobacterial pathogenesis, including endocytosis and lysosome trafficking, IL-1 signalling and the TGF-β pathway. Over-expression studies using a bovine macrophage cell-line (Bomac) reveal the targeting of two key genes in the innate immune response to M. bovis, IL-1 receptor-associated kinase 1 (IRAK1) and TGF-β receptor 2 (TGFBR2), by miR-146. Taken together, our study suggests that miRNAs play a key role in tuning the complex interplay between M. bovis survival strategies and the host immune response. Summary Mycobacterium bovis , the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expression in primary bovine AMs post-infection with M. bovis . One, six, and forty miRNAs were identified as significantly differentially expressed at 2, 24 and 48 h post-infection, respectively. The differential expression of three miRNAs (bta-miR-142-5p, bta-miR-146a, and bta-miR-423-3p) was confirmed by RT-qPCR. Pathway analysis of the predicted mRNA targets of differentially expressed miRNAs suggests that these miRNAs preferentially target several pathways that are functionally relevant for mycobacterial pathogenesis, including endocytosis and lysosome trafficking, IL-1 signalling and the TGF-β pathway. Over-expression studies using a bovine macrophage cell-line (Bomac) reveal the targeting of two key genes in the innate immune response to M. bovis , IL-1 receptor-associated kinase 1 (IRAK1) and TGF-β receptor 2 (TGFBR2) , by miR-146. Taken together, our study suggests that miRNAs play a key role in tuning the complex interplay between M. bovis survival strategies and the host immune response. Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expression in primary bovine AMs post-infection with M. bovis. One, six, and forty miRNAs were identified as significantly differentially expressed at 2, 24 and 48 h post-infection, respectively. The differential expression of three miRNAs (bta-miR-142-5p, bta-miR-146a, and bta-miR-423-3p) was confirmed by RT-qPCR. Pathway analysis of the predicted mRNA targets of differentially expressed miRNAs suggests that these miRNAs preferentially target several pathways that are functionally relevant for mycobacterial pathogenesis, including endocytosis and lysosome trafficking, IL-1 signalling and the TGF-β pathway. Over-expression studies using a bovine macrophage cell-line (Bomac) reveal the targeting of two key genes in the innate immune response to M. bovis, IL-1 receptor-associated kinase 1 (IRAK1) and TGF-β receptor 2 (TGFBR2), by miR-146. Taken together, our study suggests that miRNAs play a key role in tuning the complex interplay between M. bovis survival strategies and the host immune response.Mycobacterium bovis, the causative agent of bovine tuberculosis, a major problem for global agriculture, spreads via an airborne route and is taken up by alveolar macrophages (AM) in the lung. Here, we describe the first next-generation sequencing (RNA-seq) approach to temporally profile miRNA expression in primary bovine AMs post-infection with M. bovis. One, six, and forty miRNAs were identified as significantly differentially expressed at 2, 24 and 48 h post-infection, respectively. The differential expression of three miRNAs (bta-miR-142-5p, bta-miR-146a, and bta-miR-423-3p) was confirmed by RT-qPCR. Pathway analysis of the predicted mRNA targets of differentially expressed miRNAs suggests that these miRNAs preferentially target several pathways that are functionally relevant for mycobacterial pathogenesis, including endocytosis and lysosome trafficking, IL-1 signalling and the TGF-β pathway. Over-expression studies using a bovine macrophage cell-line (Bomac) reveal the targeting of two key genes in the innate immune response to M. bovis, IL-1 receptor-associated kinase 1 (IRAK1) and TGF-β receptor 2 (TGFBR2), by miR-146. Taken together, our study suggests that miRNAs play a key role in tuning the complex interplay between M. bovis survival strategies and the host immune response. |
| Author | MacHugh, David E. Conlon, Kevin M. McCabe, Matthew S. Gordon, Stephen V. Bradley, Daniel G. Magee, David A. Lynn, David J. Vegh, Peter Nalpas, Nicolas C. Browne, John A. Bryan, Kenneth |
| Author_xml | – sequence: 1 givenname: Peter surname: Vegh fullname: Vegh, Peter organization: Animal & Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co. Meath, Ireland – sequence: 2 givenname: David A. surname: Magee fullname: Magee, David A. organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland – sequence: 3 givenname: Nicolas C. surname: Nalpas fullname: Nalpas, Nicolas C. organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland – sequence: 4 givenname: Kenneth surname: Bryan fullname: Bryan, Kenneth organization: Animal & Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co. Meath, Ireland – sequence: 5 givenname: Matthew S. surname: McCabe fullname: McCabe, Matthew S. organization: Animal & Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co. Meath, Ireland – sequence: 6 givenname: John A. surname: Browne fullname: Browne, John A. organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland – sequence: 7 givenname: Kevin M. surname: Conlon fullname: Conlon, Kevin M. organization: UCD School of Veterinary Medicine, UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland – sequence: 8 givenname: Stephen V. surname: Gordon fullname: Gordon, Stephen V. organization: UCD School of Veterinary Medicine, UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland – sequence: 9 givenname: Daniel G. surname: Bradley fullname: Bradley, Daniel G. organization: Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland – sequence: 10 givenname: David E. surname: MacHugh fullname: MacHugh, David E. organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland – sequence: 11 givenname: David J. surname: Lynn fullname: Lynn, David J. email: david.lynn@sahmri.com organization: Animal & Bioscience Research Department, Animal & Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co. Meath, Ireland |
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| Cites_doi | 10.1371/journal.pone.0032034 10.1186/gb-2009-10-4-r42 10.1111/j.1600-065X.2008.00701.x 10.1007/s10557-011-6290-z 10.1111/j.2517-6161.1995.tb02031.x 10.1038/nri2957 10.1038/nmeth.2078 10.1038/nm.2584 10.1007/s15010-009-8450-7 10.1371/journal.pone.0027435 10.1016/j.immuni.2012.04.015 10.4049/jimmunol.1203268 10.1186/1478-811X-11-60 10.1111/j.1365-2249.2011.04381.x 10.1186/1471-2164-13-296 10.1038/nbt1394 10.1186/gb-2002-3-7-research0034 10.1038/nprot.2007.324 10.1038/msb.2008.55 10.1007/s10753-012-9443-8 10.1093/nar/gkq1027 10.1073/pnas.0605298103 10.1006/clin.1998.4528 10.1074/jbc.M111.327031 10.1089/jir.2010.0037 10.1371/journal.pone.0020258 10.1093/nar/gkq1184 10.1261/rna.030916.111 10.1091/mbc.E03-05-0307 10.1084/jem.181.1.257 10.1038/ni.2073 10.1016/j.tube.2014.04.004 10.4049/jimmunol.0900707 10.4049/jimmunol.179.2.1178 10.1093/bioinformatics/btp616 10.1016/j.vetimm.2013.08.004 10.1093/nar/29.9.e45 10.1016/S0165-2427(99)00015-X 10.1016/j.vaccine.2014.07.034 10.1186/1471-2164-14-230 10.1186/1423-0127-20-14 |
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| Keywords | microRNA Tuberculosis Bos taurus RNA-seq Mycobacterium bovis Alveolar macrophage |
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| References | Subbian, Bandyopadhyay, Tsenova, O'Brien, Khetani, Kushner, Peixoto, Soteropoulos, Bader, Karakousis, Fallows, Kaplan (bib3) 2013; 11 Fremond, Togbe, Doz, Rose, Vasseur, Maillet, Jacobs, Ryffel, Quesniaux (bib44) 2007; 179 Liu, Wheelwright, Teles, Komisopoulou, Edfeldt, Ferguson, Mehta, Vazirnia, Rea, Sarno, Graeber, Modlin (bib32) 2012; 18 Ehlers (bib2) 2009; 37 Holley, Topkara (bib6) 2011; 25 Pauls, Nanda, Smith, Toth, Arthur, Cohen (bib41) 2013; 191 Lynn, Winsor, Chan, Richard, Laird, Barsky, Gardy, Roche, Chan, Shah, Lo, Naseer, Que, Yau, Acab, Tulpan, Whiteside, Chikatamarla, Mah, Munzner, Hokamp, Hancock, Brinkman (bib22) 2008; 4 Taganov, Boldin, Chang, Baltimore (bib42) 2006; 103 Perkins, Dawes, McMahon, Bennett, Orengo, Kohl (bib27) 2012; 13 Clemens, Horwitz (bib35) 1995; 181 Pilli, Arko-Mensah, Ponpuak, Roberts, Master, Mandell, Dupont, Ornatowski, Jiang, Bradfute, Bruun, Hansen, Johansen, Deretic (bib39) 2012; 37 Golby, Villarreal-Ramos, Dean, Jones, Vordermeier (bib34) 2014; 32 Singh, Singh, Chauhan (bib8) 2013; 20 Sharbati, Lewin, Kutz-Lohroff, Kamal, Einspanier, Sharbati (bib10) 2011; 6 Robinson, McCarthy, Smyth (bib18) 2010; 26 Pfaffl (bib24) 2001; 29 Garmire, Subramaniam (bib19) 2012; 18 Ni Cheallaigh, Keane, Lavelle, Hope, Harris (bib37) 2011; 164 Schnitger, Machova, Mueller, Androulidaki, Schermer, Pasparakis, Krönke, Papadopoulou (bib29) 2011; 6 Toossi, Ellner (bib45) 1998; 87 Gantier (bib7) 2010; 30 Magee, Conlon, Nalpas, Browne, Pirson, Healy, McLoughlin, Chen, Vordermeier, Gormley, MacHugh, Gordon (bib12) 2014; 94 Nalpas, Park, Magee, Taraktsoglou, Browne, Conlon, Rue-Albrecht, Killick, Hokamp, Lohan, Loftus, Gormley, Gordon, Machugh (bib5) 2013; 14 Mullokandov, Baccarini, Ruzo, Jayaprakash, Tung, Israelow, Evans, Sachidanandam, Brown (bib20) 2012; 9 Cheng, Kuang, Hao, Zhang, Lei, Du, Jiao, Zhang, Wang (bib30) 2012; 35 WHO (bib1) 2013 Kozomara, Griffiths-Jones (bib16) 2011; 39 Friedlander, Chen, Adamidi, Maaskola, Einspanier, Knespel, Rajewsky (bib17) 2008; 26 Magee, Taraktsoglou, Killick, Nalpas, Browne, Park, Conlon, Lynn, Hokamp, Gordon, Gormley, MacHugh (bib4) 2012; 7 Vegh, Foroushani, Magee, McCabe, Browne, Nalpas, Conlon, Gordon, Bradley, MacHugh, Lynn (bib11) 2013; 155 Vergne, Fratti, Hill, Chua, Belisle, Deretic (bib36) 2004; 15 O'Neill, Sheedy, McCoy (bib33) 2011; 11 Hou, Wang, Lin, Liu, Ma, An, Wang, Cao (bib43) 2009; 183 Ma, Xu, Liu, Zhang, Xu, Liu, Hua, Li, Yao, Cao (bib9) 2011; 12 Zimin, Delcher, Florea, Kelley, Schatz, Puiu, Hanrahan, Pertea, Van Tassell, Sonstegard, Marcais, Roberts, Subramanian, Yorke, Salzberg (bib15) 2009; 10 Benjamini, Hochberg (bib23) 1995; 57 Martin (bib14) 2011 Deretic, Delgado, Vergne, Master, De Haro, Ponpuak, Singh (bib38) 2009; 335 Vandesompele, De Preter, Pattyn, Poppe, Van Roy, De Paepe, Speleman (bib26) 2002; 3 Graff, Dickson, Clay, McCaffrey, Wilson (bib31) 2012; 287 O'Neill (bib28) 2008; 226 Liu, Park, Abraham (bib40) 2008; 22 Cline, Smoot, Cerami, Kuchinsky, Landys, Workman, Christmas, Avila-Campilo, Creech, Gross, Hanspers, Isserlin, Kelley, Killcoyne, Lotia, Maere, Morris, Ono, Pavlovic, Pico, Vailaya, Wang, Adler, Conklin, Hood, Kuiper, Sander, Schmulevich, Schwikowski, Warner, Ideker, Bader (bib21) 2007; 2 Sager, Davis, Jungi (bib25) 1999; 68 Barrett, Troup, Wilhite, Ledoux, Evangelista, Kim, Tomashevsky, Marshall, Phillippy, Sherman, Muertter, Holko, Ayanbule, Yefanov, Soboleva (bib13) 2011; 39 Vandesompele (10.1016/j.tube.2014.10.011_bib26) 2002; 3 Martin (10.1016/j.tube.2014.10.011_bib14) 2011 Zimin (10.1016/j.tube.2014.10.011_bib15) 2009; 10 Fremond (10.1016/j.tube.2014.10.011_bib44) 2007; 179 Toossi (10.1016/j.tube.2014.10.011_bib45) 1998; 87 Liu (10.1016/j.tube.2014.10.011_bib32) 2012; 18 Vergne (10.1016/j.tube.2014.10.011_bib36) 2004; 15 Vegh (10.1016/j.tube.2014.10.011_bib11) 2013; 155 Sharbati (10.1016/j.tube.2014.10.011_bib10) 2011; 6 Clemens (10.1016/j.tube.2014.10.011_bib35) 1995; 181 Lynn (10.1016/j.tube.2014.10.011_bib22) 2008; 4 Ni Cheallaigh (10.1016/j.tube.2014.10.011_bib37) 2011; 164 Liu (10.1016/j.tube.2014.10.011_bib40) 2008; 22 Magee (10.1016/j.tube.2014.10.011_bib4) 2012; 7 Garmire (10.1016/j.tube.2014.10.011_bib19) 2012; 18 Taganov (10.1016/j.tube.2014.10.011_bib42) 2006; 103 Singh (10.1016/j.tube.2014.10.011_bib8) 2013; 20 Cline (10.1016/j.tube.2014.10.011_bib21) 2007; 2 Perkins (10.1016/j.tube.2014.10.011_bib27) 2012; 13 Sager (10.1016/j.tube.2014.10.011_bib25) 1999; 68 Barrett (10.1016/j.tube.2014.10.011_bib13) 2011; 39 Pauls (10.1016/j.tube.2014.10.011_bib41) 2013; 191 Subbian (10.1016/j.tube.2014.10.011_bib3) 2013; 11 Nalpas (10.1016/j.tube.2014.10.011_bib5) 2013; 14 Holley (10.1016/j.tube.2014.10.011_bib6) 2011; 25 Ehlers (10.1016/j.tube.2014.10.011_bib2) 2009; 37 O'Neill (10.1016/j.tube.2014.10.011_bib33) 2011; 11 Ma (10.1016/j.tube.2014.10.011_bib9) 2011; 12 Mullokandov (10.1016/j.tube.2014.10.011_bib20) 2012; 9 O'Neill (10.1016/j.tube.2014.10.011_bib28) 2008; 226 Friedlander (10.1016/j.tube.2014.10.011_bib17) 2008; 26 Kozomara (10.1016/j.tube.2014.10.011_bib16) 2011; 39 Benjamini (10.1016/j.tube.2014.10.011_bib23) 1995; 57 Cheng (10.1016/j.tube.2014.10.011_bib30) 2012; 35 Golby (10.1016/j.tube.2014.10.011_bib34) 2014; 32 Magee (10.1016/j.tube.2014.10.011_bib12) 2014; 94 Graff (10.1016/j.tube.2014.10.011_bib31) 2012; 287 Schnitger (10.1016/j.tube.2014.10.011_bib29) 2011; 6 Deretic (10.1016/j.tube.2014.10.011_bib38) 2009; 335 Pilli (10.1016/j.tube.2014.10.011_bib39) 2012; 37 WHO (10.1016/j.tube.2014.10.011_bib1) 2013 Robinson (10.1016/j.tube.2014.10.011_bib18) 2010; 26 Hou (10.1016/j.tube.2014.10.011_bib43) 2009; 183 Pfaffl (10.1016/j.tube.2014.10.011_bib24) 2001; 29 Gantier (10.1016/j.tube.2014.10.011_bib7) 2010; 30 |
| References_xml | – volume: 57 start-page: 289 year: 1995 end-page: 300 ident: bib23 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J R Stat Soc Ser B Methodol – volume: 39 start-page: D152 year: 2011 end-page: D157 ident: bib16 article-title: Mirbase: integrating microRNA annotation and deep-sequencing data publication-title: Nucleic Acids Res – volume: 9 start-page: 840 year: 2012 end-page: 846 ident: bib20 article-title: High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries publication-title: Nat Methods – volume: 6 start-page: e27435 year: 2011 ident: bib29 article-title: infection in macrophages induces vacuolar-dependent host miRNA response publication-title: PLoS One – volume: 37 start-page: 87 year: 2009 end-page: 95 ident: bib2 article-title: Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis publication-title: Infection – volume: 13 start-page: 296 year: 2012 ident: bib27 article-title: ReadqPCR and normqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (cq) data publication-title: BMC Genomics – volume: 87 start-page: 107 year: 1998 end-page: 114 ident: bib45 article-title: The role of TGF beta in the pathogenesis of human tuberculosis publication-title: Clin Immunol Immunopathol – volume: 18 start-page: 267 year: 2012 end-page: 273 ident: bib32 article-title: MicroRNA-21 targets the vitamin d-dependent antimicrobial pathway in leprosy publication-title: Nat Med – volume: 191 start-page: 2717 year: 2013 end-page: 2730 ident: bib41 article-title: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice publication-title: J Immunol – volume: 29 start-page: e45 year: 2001 ident: bib24 article-title: A new mathematical model for relative quantification in real-time RT-PCR publication-title: Nucleic Acids Res – volume: 14 start-page: 230 year: 2013 ident: bib5 article-title: Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to publication-title: BMC Genomics – volume: 12 start-page: 861 year: 2011 end-page: 869 ident: bib9 article-title: The microRNA mir-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma publication-title: Nat Immunol – volume: 18 start-page: 1279 year: 2012 end-page: 1288 ident: bib19 article-title: Evaluation of normalization methods in mammalian microRNA-seq data publication-title: RNA – volume: 335 start-page: 169 year: 2009 end-page: 188 ident: bib38 article-title: Autophagy in immunity against publication-title: Curr Top Microbiol Immunol – volume: 7 start-page: e32034 year: 2012 ident: bib4 article-title: Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with publication-title: PLoS One – volume: 10 start-page: R42 year: 2009 ident: bib15 article-title: A whole-genome assembly of the domestic cow, bos taurus publication-title: Genome Biol – volume: 20 start-page: 14 year: 2013 ident: bib8 article-title: Current understanding on micro RNAs and its regulation in response to mycobacterial infections publication-title: J Biomed Sci – volume: 15 start-page: 751 year: 2004 end-page: 760 ident: bib36 article-title: phagosome maturation arrest: publication-title: Mol Biol Cell – volume: 3 year: 2002 ident: bib26 article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes publication-title: Genome Biol – volume: 2 start-page: 2366 year: 2007 end-page: 2382 ident: bib21 article-title: Integration of biological networks and gene expression data using cytoscape publication-title: Nat Protoc – volume: 39 start-page: D1005 year: 2011 end-page: D1010 ident: bib13 article-title: Ncbi geo: archive for functional genomics data sets–10 years on publication-title: Nucleic Acids Res – volume: 68 start-page: 113 year: 1999 end-page: 130 ident: bib25 article-title: Bovine monocytoid cells transformed to proliferate cease to exhibit lineage-specific functions publication-title: Vet Immunol Immunopathol – volume: 179 start-page: 1178 year: 2007 end-page: 1189 ident: bib44 article-title: Il-1 receptor-mediated signal is an essential component of myd88-dependent innate response to publication-title: J Immunol – volume: 35 start-page: 1308 year: 2012 end-page: 1313 ident: bib30 article-title: Downregulation of mir-27a* and mir-532-5p and upregulation of mir-146a and mir-155 in LPS-induced raw264.7 macrophage cells publication-title: Inflammation – year: 2013 ident: bib1 article-title: Global tuberculosis report – volume: 30 start-page: 283 year: 2010 end-page: 289 ident: bib7 article-title: New perspectives in microRNA regulation of innate immunity publication-title: J Interferon Cytokine Res – volume: 22 start-page: 2285 year: 2008 end-page: 2296 ident: bib40 article-title: Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappab activation requires cytosolic and nuclear activity publication-title: FASEB J – Off Publ Fed Am Soc Exp Biol – volume: 26 start-page: 139 year: 2010 end-page: 140 ident: bib18 article-title: Edger: a bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics – volume: 103 start-page: 12481 year: 2006 end-page: 12486 ident: bib42 article-title: NF-kappaB-dependent induction of microRNA mir-146, an inhibitor targeted to signaling proteins of innate immune responses publication-title: Proc Natl Acad Sci U S A – volume: 4 start-page: 218 year: 2008 ident: bib22 article-title: InnateDB: facilitating systems-level analyses of the mammalian innate immune response publication-title: Mol Syst Biol – volume: 94 start-page: 441 year: 2014 end-page: 450 ident: bib12 article-title: Innate cytokine profiling of bovine alveolar macrophages reveals commonalities and divergence in the response to publication-title: Tuberc – Edinb – volume: 26 start-page: 407 year: 2008 end-page: 415 ident: bib17 article-title: Discovering micrornas from deep sequencing data using mirdeep publication-title: Nat Biotechnol – volume: 37 start-page: 223 year: 2012 end-page: 234 ident: bib39 article-title: TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation publication-title: Immunity – volume: 287 start-page: 21816 year: 2012 end-page: 21825 ident: bib31 article-title: Identifying functional microRNAs in macrophages with polarized phenotypes publication-title: J Biol Chem – volume: 25 start-page: 151 year: 2011 end-page: 159 ident: bib6 article-title: An introduction to small non-coding RNAs: miRNA and snoRNA publication-title: Cardiovasc Drugs Therapy – Sponsored Int Soc Cardiovasc Pharmacother – volume: 11 start-page: 60 year: 2013 ident: bib3 article-title: Early innate immunity determines outcome of mycobacterium tuberculosis pulmonary infection in rabbits publication-title: Cell Commun Signal – volume: 181 start-page: 257 year: 1995 end-page: 270 ident: bib35 article-title: Characterization of the mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited publication-title: J Exp Med – volume: 6 start-page: e20258 year: 2011 ident: bib10 article-title: Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon mycobacterium avium subsp. Hominissuis infection publication-title: PLoS One – volume: 155 start-page: 238 year: 2013 end-page: 244 ident: bib11 article-title: Profiling microRNA expression in bovine alveolar macrophages using RNA-seq publication-title: Vet Immunol Immunopathol – volume: 226 start-page: 10 year: 2008 end-page: 18 ident: bib28 article-title: The interleukin-1 receptor/toll-like receptor superfamily: 10 years of progress publication-title: Immunol Rev – volume: 11 start-page: 163 year: 2011 end-page: 175 ident: bib33 article-title: Micrornas: the fine-tuners of toll-like receptor signalling publication-title: Nat Rev Immunol – volume: 183 start-page: 2150 year: 2009 end-page: 2158 ident: bib43 article-title: MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2 publication-title: J Immunol – year: 2011 ident: bib14 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads – volume: 164 start-page: 291 year: 2011 end-page: 300 ident: bib37 article-title: Autophagy in the immune response to tuberculosis: clinical perspectives publication-title: Clin Exp Immunol – volume: 32 start-page: 5839 year: 2014 end-page: 5844 ident: bib34 article-title: MicroRNA expression profiling of PPD-B stimulated PBMC from publication-title: Vaccine – volume: 7 start-page: e32034 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib4 article-title: Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis publication-title: PLoS One doi: 10.1371/journal.pone.0032034 – volume: 10 start-page: R42 year: 2009 ident: 10.1016/j.tube.2014.10.011_bib15 article-title: A whole-genome assembly of the domestic cow, bos taurus publication-title: Genome Biol doi: 10.1186/gb-2009-10-4-r42 – volume: 226 start-page: 10 year: 2008 ident: 10.1016/j.tube.2014.10.011_bib28 article-title: The interleukin-1 receptor/toll-like receptor superfamily: 10 years of progress publication-title: Immunol Rev doi: 10.1111/j.1600-065X.2008.00701.x – volume: 25 start-page: 151 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib6 article-title: An introduction to small non-coding RNAs: miRNA and snoRNA publication-title: Cardiovasc Drugs Therapy – Sponsored Int Soc Cardiovasc Pharmacother doi: 10.1007/s10557-011-6290-z – volume: 57 start-page: 289 year: 1995 ident: 10.1016/j.tube.2014.10.011_bib23 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: J R Stat Soc Ser B Methodol doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 11 start-page: 163 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib33 article-title: Micrornas: the fine-tuners of toll-like receptor signalling publication-title: Nat Rev Immunol doi: 10.1038/nri2957 – volume: 9 start-page: 840 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib20 article-title: High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries publication-title: Nat Methods doi: 10.1038/nmeth.2078 – volume: 18 start-page: 267 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib32 article-title: MicroRNA-21 targets the vitamin d-dependent antimicrobial pathway in leprosy publication-title: Nat Med doi: 10.1038/nm.2584 – volume: 37 start-page: 87 year: 2009 ident: 10.1016/j.tube.2014.10.011_bib2 article-title: Lazy, dynamic or minimally recrudescent? On the elusive nature and location of the mycobacterium responsible for latent tuberculosis publication-title: Infection doi: 10.1007/s15010-009-8450-7 – volume: 6 start-page: e27435 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib29 article-title: Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response publication-title: PLoS One doi: 10.1371/journal.pone.0027435 – volume: 37 start-page: 223 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib39 article-title: TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation publication-title: Immunity doi: 10.1016/j.immuni.2012.04.015 – volume: 191 start-page: 2717 year: 2013 ident: 10.1016/j.tube.2014.10.011_bib41 article-title: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice publication-title: J Immunol doi: 10.4049/jimmunol.1203268 – volume: 11 start-page: 60 year: 2013 ident: 10.1016/j.tube.2014.10.011_bib3 article-title: Early innate immunity determines outcome of mycobacterium tuberculosis pulmonary infection in rabbits publication-title: Cell Commun Signal doi: 10.1186/1478-811X-11-60 – volume: 164 start-page: 291 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib37 article-title: Autophagy in the immune response to tuberculosis: clinical perspectives publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2011.04381.x – volume: 13 start-page: 296 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib27 article-title: ReadqPCR and normqPCR: R packages for the reading, quality checking and normalisation of RT-qPCR quantification cycle (cq) data publication-title: BMC Genomics doi: 10.1186/1471-2164-13-296 – volume: 26 start-page: 407 year: 2008 ident: 10.1016/j.tube.2014.10.011_bib17 article-title: Discovering micrornas from deep sequencing data using mirdeep publication-title: Nat Biotechnol doi: 10.1038/nbt1394 – volume: 3 year: 2002 ident: 10.1016/j.tube.2014.10.011_bib26 article-title: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes publication-title: Genome Biol doi: 10.1186/gb-2002-3-7-research0034 – volume: 2 start-page: 2366 year: 2007 ident: 10.1016/j.tube.2014.10.011_bib21 article-title: Integration of biological networks and gene expression data using cytoscape publication-title: Nat Protoc doi: 10.1038/nprot.2007.324 – volume: 4 start-page: 218 year: 2008 ident: 10.1016/j.tube.2014.10.011_bib22 article-title: InnateDB: facilitating systems-level analyses of the mammalian innate immune response publication-title: Mol Syst Biol doi: 10.1038/msb.2008.55 – volume: 35 start-page: 1308 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib30 article-title: Downregulation of mir-27a* and mir-532-5p and upregulation of mir-146a and mir-155 in LPS-induced raw264.7 macrophage cells publication-title: Inflammation doi: 10.1007/s10753-012-9443-8 – volume: 39 start-page: D152 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib16 article-title: Mirbase: integrating microRNA annotation and deep-sequencing data publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq1027 – year: 2011 ident: 10.1016/j.tube.2014.10.011_bib14 – volume: 335 start-page: 169 year: 2009 ident: 10.1016/j.tube.2014.10.011_bib38 article-title: Autophagy in immunity against Mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy publication-title: Curr Top Microbiol Immunol – volume: 103 start-page: 12481 year: 2006 ident: 10.1016/j.tube.2014.10.011_bib42 article-title: NF-kappaB-dependent induction of microRNA mir-146, an inhibitor targeted to signaling proteins of innate immune responses publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0605298103 – volume: 87 start-page: 107 year: 1998 ident: 10.1016/j.tube.2014.10.011_bib45 article-title: The role of TGF beta in the pathogenesis of human tuberculosis publication-title: Clin Immunol Immunopathol doi: 10.1006/clin.1998.4528 – volume: 287 start-page: 21816 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib31 article-title: Identifying functional microRNAs in macrophages with polarized phenotypes publication-title: J Biol Chem doi: 10.1074/jbc.M111.327031 – volume: 22 start-page: 2285 year: 2008 ident: 10.1016/j.tube.2014.10.011_bib40 article-title: Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappab activation requires cytosolic and nuclear activity publication-title: FASEB J – Off Publ Fed Am Soc Exp Biol – volume: 30 start-page: 283 year: 2010 ident: 10.1016/j.tube.2014.10.011_bib7 article-title: New perspectives in microRNA regulation of innate immunity publication-title: J Interferon Cytokine Res doi: 10.1089/jir.2010.0037 – volume: 6 start-page: e20258 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib10 article-title: Integrated microRNA-mRNA-analysis of human monocyte derived macrophages upon mycobacterium avium subsp. Hominissuis infection publication-title: PLoS One doi: 10.1371/journal.pone.0020258 – volume: 39 start-page: D1005 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib13 article-title: Ncbi geo: archive for functional genomics data sets–10 years on publication-title: Nucleic Acids Res doi: 10.1093/nar/gkq1184 – volume: 18 start-page: 1279 year: 2012 ident: 10.1016/j.tube.2014.10.011_bib19 article-title: Evaluation of normalization methods in mammalian microRNA-seq data publication-title: RNA doi: 10.1261/rna.030916.111 – volume: 15 start-page: 751 year: 2004 ident: 10.1016/j.tube.2014.10.011_bib36 article-title: Mycobacterium tuberculosis phagosome maturation arrest: Mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion publication-title: Mol Biol Cell doi: 10.1091/mbc.E03-05-0307 – volume: 181 start-page: 257 year: 1995 ident: 10.1016/j.tube.2014.10.011_bib35 article-title: Characterization of the mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited publication-title: J Exp Med doi: 10.1084/jem.181.1.257 – volume: 12 start-page: 861 year: 2011 ident: 10.1016/j.tube.2014.10.011_bib9 article-title: The microRNA mir-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-gamma publication-title: Nat Immunol doi: 10.1038/ni.2073 – volume: 94 start-page: 441 issue: 4 year: 2014 ident: 10.1016/j.tube.2014.10.011_bib12 article-title: Innate cytokine profiling of bovine alveolar macrophages reveals commonalities and divergence in the response to Mycobacterium bovis and Mycobacterium tuberculosis infection publication-title: Tuberc – Edinb doi: 10.1016/j.tube.2014.04.004 – volume: 183 start-page: 2150 year: 2009 ident: 10.1016/j.tube.2014.10.011_bib43 article-title: MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2 publication-title: J Immunol doi: 10.4049/jimmunol.0900707 – volume: 179 start-page: 1178 year: 2007 ident: 10.1016/j.tube.2014.10.011_bib44 article-title: Il-1 receptor-mediated signal is an essential component of myd88-dependent innate response to Mycobacterium tuberculosis infection publication-title: J Immunol doi: 10.4049/jimmunol.179.2.1178 – volume: 26 start-page: 139 year: 2010 ident: 10.1016/j.tube.2014.10.011_bib18 article-title: Edger: a bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp616 – volume: 155 start-page: 238 year: 2013 ident: 10.1016/j.tube.2014.10.011_bib11 article-title: Profiling microRNA expression in bovine alveolar macrophages using RNA-seq publication-title: Vet Immunol Immunopathol doi: 10.1016/j.vetimm.2013.08.004 – volume: 29 start-page: e45 year: 2001 ident: 10.1016/j.tube.2014.10.011_bib24 article-title: A new mathematical model for relative quantification in real-time RT-PCR publication-title: Nucleic Acids Res doi: 10.1093/nar/29.9.e45 – volume: 68 start-page: 113 year: 1999 ident: 10.1016/j.tube.2014.10.011_bib25 article-title: Bovine monocytoid cells transformed to proliferate cease to exhibit lineage-specific functions publication-title: Vet Immunol Immunopathol doi: 10.1016/S0165-2427(99)00015-X – volume: 32 start-page: 5839 year: 2014 ident: 10.1016/j.tube.2014.10.011_bib34 article-title: MicroRNA expression profiling of PPD-B stimulated PBMC from M. Bovis-challenged unvaccinated and BCG vaccinated cattle publication-title: Vaccine doi: 10.1016/j.vaccine.2014.07.034 – volume: 14 start-page: 230 year: 2013 ident: 10.1016/j.tube.2014.10.011_bib5 article-title: Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro publication-title: BMC Genomics doi: 10.1186/1471-2164-14-230 – year: 2013 ident: 10.1016/j.tube.2014.10.011_bib1 – volume: 20 start-page: 14 year: 2013 ident: 10.1016/j.tube.2014.10.011_bib8 article-title: Current understanding on micro RNAs and its regulation in response to mycobacterial infections publication-title: J Biomed Sci doi: 10.1186/1423-0127-20-14 |
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| SubjectTerms | Alveolar macrophage Animals Bos taurus Cattle Cells, Cultured Down-Regulation Endocytosis - immunology Gene Expression - genetics Gene Expression - immunology Gene Expression Profiling - methods Immunity, Innate - immunology Infectious Disease Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors Lysosomes - immunology Macrophages, Alveolar - immunology Male microRNA MicroRNAs - genetics MicroRNAs - immunology MicroRNAs - physiology Mycobacterium bovis Mycobacterium bovis - immunology Pulmonary/Respiratory Real-Time Polymerase Chain Reaction - methods RNA, Bacterial - genetics RNA, Bacterial - immunology RNA-seq Sequence Analysis, RNA - methods Transfection - methods Transforming Growth Factor beta2 - antagonists & inhibitors Tuberculosis Tuberculosis, Bovine - immunology Tuberculosis, Pulmonary - immunology Up-Regulation |
| Title | MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium bovis infection suggests pathogen survival is enhanced by microRNA regulation of endocytosis and lysosome trafficking |
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