Comparison and improvement of algorithms for computing minimal cut sets

Background Constrained minimal cut sets (cMCSs) have recently been introduced as a framework to enumerate minimal genetic intervention strategies for targeted optimization of metabolic networks. Two different algorithmic schemes (adapted Berge algorithm and binary integer programming) have been prop...

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Bibliographic Details
Published in:	BMC bioinformatics Vol. 14; no. 1; p. 318
Main Authors:	Jungreuthmayer, Christian, Nair, Govind, Klamt, Steffen, Zanghellini, Jürgen
Format:	Journal Article
Language:	English
Published:	London BioMed Central 06.11.2013 BioMed Central Ltd
Subjects:	Algorithms Analysis Bioinformatics Biomedical and Life Sciences Cell metabolism Comparative analysis Computational Biology - methods Computational Biology/Bioinformatics Computer Appl. in Life Sciences Computer Simulation Escherichia coli - genetics Gene Deletion Gene Knockout Techniques Humans Image Processing, Computer-Assisted Life Sciences Metabolic Networks and Pathways - genetics Methodology Methodology Article Microarrays Models, Genetic Networks analysis Software Thermodynamics Integer programming Metabolic network analysis Knockout strategies Minimal cut sets Berge’s algorithm Elementary modes
ISSN:	1471-2105, 1471-2105
Online Access:	Get full text
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