Accuracy of QuantiFERON SARS-CoV-2 research use only assay and characterization of the CD4+ and CD8+ T cell-SARS-CoV-2 response: comparison with a homemade interferon-γ release assay

•The QuantiFERON SARS-CoV-2 research use only assay response is mediated by CD4+ and CD8+ T cells.•Immune response to the antigen (Ag)2 tube is more accurate than that to the Ag1 tube.•Responses to QuantiFERON SARS-CoV-2 tubes are lower compared with a homemade test.•The QuantiFERON SARS-CoV-2 diffe...

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Bibliographic Details
Published in:	International journal of infectious diseases Vol. 122; pp. 841 - 849
Main Authors:	Aiello, Alessandra, Coppola, Andrea, Vanini, Valentina, Petrone, Linda, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria Gerarda, Tortorella, Carla, Gualano, Gina, Gasperini, Claudio, Scolieri, Palma, Beccacece, Alessia, Vita, Serena, Bruzzese, Vincenzo, Lorenzetti, Roberto, Palmieri, Fabrizio, Nicastri, Emanuele, Goletti, Delia
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01.09.2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases Elsevier
Subjects:	CD4-Positive T-Lymphocytes CD8-Positive T-Lymphocytes COVID-19 COVID-19 - diagnosis Humans IFN-γ release assay (IGRA), T cell response Interferon-gamma Release Tests Mycobacterium tuberculosis QuantiFERON SARS-CoV-2 tubes SARS-CoV-2 Spike peptides Tuberculosis Whole-blood COVID-19 QuantiFERON SARS-CoV-2 tubes Whole-blood Spike peptides IFN-γ release assay (IGRA), T cell response
ISSN:	1201-9712, 1878-3511, 1878-3511
Online Access:	Get full text
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