Higher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study

Obesity is of complex origin, involving genetic and neurobehavioral factors. Genetic polymorphisms may increase the risk for developing obesity by modulating dopamine-dependent behaviors, such as reward processing. Yet, few studies have investigated the association of obesity, related genetic varian...

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Bibliographic Details
Published in:	International Journal of Obesity Vol. 45; no. 3; pp. 491 - 501
Main Authors:	Beyer, Frauke, Zhang, Rui, Scholz, Markus, Wirkner, Kerstin, Loeffler, Markus, Stumvoll, Michael, Villringer, Arno, Witte, A Veronica
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.03.2021
Subjects:	Adult Anisotropy Body Mass Index Brain - diagnostic imaging Brain - physiology Brain - physiopathology Clustering Diffusion Magnetic Resonance Imaging Dopamine Dopamine D2 receptors Gene polymorphism Genetic diversity Genetic variance Genetics Genotyping Humans Magnetic resonance imaging Middle Aged Neostriatum Neural networks Neural Pathways - diagnostic imaging Neural Pathways - physiology Neural Pathways - physiopathology Neuroimaging Nucleus accumbens Obesity Obesity - epidemiology Obesity - genetics Obesity - physiopathology Polymorphism Polymorphism, Single Nucleotide - genetics Population studies Population-based studies Putamen Receptors Reinforcement Reward Substantia alba Young Adult
ISSN:	0307-0565, 1476-5497, 1476-5497
Online Access:	Get full text
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