Gestational Diseases — A Workshop Report

Between 11% and 20% of all clinically recognised pregnancies are lost before the 20th week of gestation, with huge financial and personal implications. Immune mechanisms have been proposed to play a role in unexplained recurrent miscarriage. Considerable attention has focused on endometrial leucocyt...

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Bibliographic Details
Published in:Placenta (Eastbourne) Vol. 29; pp. 92 - 94
Main Authors: Lash, G.E., Quenby, S., Burton, G.J., Nakashima, A., Kamat, B.R., Ray, J., Bulmer, J.N.
Format: Journal Article Conference Proceeding
Language:English
Published: Oxford Elsevier Ltd 01.03.2008
Elsevier
Subjects:
Abortion, Spontaneous - immunology
Abortion, Spontaneous - metabolism
Abortion, Spontaneous - pathology
Biological and medical sciences
Education
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Humans
Hydatidiform mole
Hydatidiform Mole - immunology
Hydatidiform Mole - metabolism
Hydatidiform Mole - pathology
Internal Medicine
Miscarriage
Obstetrics and Gynecology
Oxidative Stress
Pregnancy
Proliferation
Uterine natural killer cells
Uterus - immunology
Uterus - metabolism
Uterus - pathology
Oxidative stress
Proliferation
Hydatidiform mole
Miscarriage
Uterine natural killer cells
Pregnancy
Vertebrata
Mammalia
ISSN:0143-4004, 1532-3102
Online Access:Get full text
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Summary:Between 11% and 20% of all clinically recognised pregnancies are lost before the 20th week of gestation, with huge financial and personal implications. Immune mechanisms have been proposed to play a role in unexplained recurrent miscarriage. Considerable attention has focused on endometrial leucocyte populations in recurrent miscarriage, although the underlying pathogenesis remains largely unexplained. The mechanisms underlying sporadic miscarriage are even less well understood, although aneuploidy is the commonest attributable cause of early (≤12 completed weeks gestation) sporadic miscarriage. Hydatidiform mole is a rare cause of early pregnancy loss with marked geographical variation in incidence. Both complete and partial hydatidiform mole are associated with excessive trophoblast proliferation and hence provide an opportunity to study trophoblast growth regulation.
Bibliography:SourceType-Scholarly Journals-1
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ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2007.10.004