Emerging concepts in PD-1 checkpoint biology

•The PD-1 pathway plays multifaceted roles in regulating immune responses.•PD-1 can modulate effector and memory T cells, Treg cells, NK cells, and ILCs.•PD-1 regulates anti-tumor T cells in the draining lymph node as well as in the tumor.•Timing of PD-1 inhibition may be important for durable anti-...

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Bibliographic Details
Published in:	Seminars in immunology Vol. 52; p. 101480
Main Authors:	Pauken, Kristen E., Torchia, James A., Chaudhri, Apoorvi, Sharpe, Arlene H., Freeman, Gordon J.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.02.2021
Subjects:	Cancer immunotherapy Humans Immune Checkpoint Inhibitors - therapeutic use Immune regulation Killer Cells, Natural Lymphocyte Activation Neoadjuvant Neoplasms - therapy PD-1 pathway Programmed Cell Death 1 Receptor - antagonists & inhibitors T cell exhaustion ILC TCR FDA LCMV MSIhi T cell exhaustion MHC Neoadjuvant RGMb Cancer immunotherapy TNF ORR IFN GBM LAG-3 MMRd PD-L1 PD-L2 INMC CTLA-4 TIM-3 PD-1 pathway pCR CD NSCLC TCF-1 MMPr Treg TMB Immune regulation RCC APC CAR TIL irAE PD-1 NK HPD DC
ISSN:	1044-5323, 1096-3618, 1096-3618
Online Access:	Get full text
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