Consensus Statement on the Use of Bone Turnover Markers for Short-Term Monitoring of Osteoporosis Treatment in the Asia-Pacific Region
Osteoporosis is a major health issue. By 2050, a greater than 2-fold increase in patients number with hip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial....
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| Veröffentlicht in: | Journal of clinical densitometry Jg. 24; H. 1; S. 3 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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01.01.2021
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| ISSN: | 1094-6950 |
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| Abstract | Osteoporosis is a major health issue. By 2050, a greater than 2-fold increase in patients number with hip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis and monitor osteoporosis treatment. However, the inconvenience, cost, limited availability of DXA and the delay in detection of BMD changes after treatment initiation support an important role for bone turnover markers (BTMs), as short-term tools to monitor therapy. With regards to low adherence rates of medical treatment of osteoporosis, the experts reached consensus on the use of BTMs for both raising awareness and short-term monitoring of osteoporosis treatment in the AP region. The experts endorse the use of BTMs, especially serum C-terminal telopeptide of type 1 collagen (CTX) and serum procollagen type 1 N propeptide (P1NP), as short-term monitoring tools to help clinicians assess the responses to osteoporosis therapies and appropriately adjust treatment regimens earlier than BMD. Either the absolute values or the degree of change from baseline in BTMs can be used to monitor the potential efficacy of osteoporosis therapies. The use of BTMs can be incorporated in osteoporosis care programs, such as fracture liaison service (FLS), to improve patient adherence and treatment outcomes. Encouraging sufficient reimbursement from health care systems may facilitate widespread use of BTMs in clinical practice in the AP region. |
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| AbstractList | Osteoporosis is a major health issue. By 2050, a greater than 2-fold increase in patients number with hip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis and monitor osteoporosis treatment. However, the inconvenience, cost, limited availability of DXA and the delay in detection of BMD changes after treatment initiation support an important role for bone turnover markers (BTMs), as short-term tools to monitor therapy. With regards to low adherence rates of medical treatment of osteoporosis, the experts reached consensus on the use of BTMs for both raising awareness and short-term monitoring of osteoporosis treatment in the AP region. The experts endorse the use of BTMs, especially serum C-terminal telopeptide of type 1 collagen (CTX) and serum procollagen type 1 N propeptide (P1NP), as short-term monitoring tools to help clinicians assess the responses to osteoporosis therapies and appropriately adjust treatment regimens earlier than BMD. Either the absolute values or the degree of change from baseline in BTMs can be used to monitor the potential efficacy of osteoporosis therapies. The use of BTMs can be incorporated in osteoporosis care programs, such as fracture liaison service (FLS), to improve patient adherence and treatment outcomes. Encouraging sufficient reimbursement from health care systems may facilitate widespread use of BTMs in clinical practice in the AP region. Osteoporosis is a major health issue. By 2050, a greater than 2-fold increase in patients number with hip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis and monitor osteoporosis treatment. However, the inconvenience, cost, limited availability of DXA and the delay in detection of BMD changes after treatment initiation support an important role for bone turnover markers (BTMs), as short-term tools to monitor therapy. With regards to low adherence rates of medical treatment of osteoporosis, the experts reached consensus on the use of BTMs for both raising awareness and short-term monitoring of osteoporosis treatment in the AP region. The experts endorse the use of BTMs, especially serum C-terminal telopeptide of type 1 collagen (CTX) and serum procollagen type 1 N propeptide (P1NP), as short-term monitoring tools to help clinicians assess the responses to osteoporosis therapies and appropriately adjust treatment regimens earlier than BMD. Either the absolute values or the degree of change from baseline in BTMs can be used to monitor the potential efficacy of osteoporosis therapies. The use of BTMs can be incorporated in osteoporosis care programs, such as fracture liaison service (FLS), to improve patient adherence and treatment outcomes. Encouraging sufficient reimbursement from health care systems may facilitate widespread use of BTMs in clinical practice in the AP region.Osteoporosis is a major health issue. By 2050, a greater than 2-fold increase in patients number with hip fractures will occur in Asia representing 50% of all hip fractures worldwide. For the Asia-Pacific (AP) region, more efforts on controlling osteoporosis and the subsequent fractures are crucial. Bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA) is commonly used to diagnose osteoporosis and monitor osteoporosis treatment. However, the inconvenience, cost, limited availability of DXA and the delay in detection of BMD changes after treatment initiation support an important role for bone turnover markers (BTMs), as short-term tools to monitor therapy. With regards to low adherence rates of medical treatment of osteoporosis, the experts reached consensus on the use of BTMs for both raising awareness and short-term monitoring of osteoporosis treatment in the AP region. The experts endorse the use of BTMs, especially serum C-terminal telopeptide of type 1 collagen (CTX) and serum procollagen type 1 N propeptide (P1NP), as short-term monitoring tools to help clinicians assess the responses to osteoporosis therapies and appropriately adjust treatment regimens earlier than BMD. Either the absolute values or the degree of change from baseline in BTMs can be used to monitor the potential efficacy of osteoporosis therapies. The use of BTMs can be incorporated in osteoporosis care programs, such as fracture liaison service (FLS), to improve patient adherence and treatment outcomes. Encouraging sufficient reimbursement from health care systems may facilitate widespread use of BTMs in clinical practice in the AP region. |
| Author | Saag, Kenneth Cheung, Ching-Lung Reid, Ian Lin, Gau-Tyan Tsai, Keh-Sung Lee, Joon-Kiong Yu, Wei Mercado-Asis, Leilani B Yang, Rong-Sen Tu, Shih-Te Xia, Weibo Chung, Yoon-Sok Mithal, Ambrish Chang, Yin-Fan Ferrari, Serge Livio Cooper, Cyrus Chan, Ding-Cheng Matsumoto, Toshio Lewiecki, E Michael Hwang, Jawl-Shan Chen, Chung-Hwan Wüster, Christian Wu, Chih-Hsing Ebeling, Peter |
| Author_xml | – sequence: 1 givenname: Chih-Hsing surname: Wu fullname: Wu, Chih-Hsing organization: Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Geriatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan – sequence: 2 givenname: Yin-Fan surname: Chang fullname: Chang, Yin-Fan organization: Department of Family Medicine, National Cheng Kung University Hospital, Tainan, Taiwan; College of Medicine, National Cheng Kung University, Tainan, Taiwan – sequence: 3 givenname: Chung-Hwan surname: Chen fullname: Chen, Chung-Hwan organization: Orthopaedic Research Centre, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopaedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Departments of Orthopaedics, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Orthopaedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung City, Taiwan – sequence: 4 givenname: E Michael surname: Lewiecki fullname: Lewiecki, E Michael organization: New Mexico Clinical Research & Osteoporosis Center, Albuquerque, NM, USA – sequence: 5 givenname: Christian surname: Wüster fullname: Wüster, Christian organization: Hormone & Bone Metabolic Center & Dept. of Orthopedic Surgery, Johannes Gutenberg University of Mainz, D-55122, Mainz, Germany – sequence: 6 givenname: Ian surname: Reid fullname: Reid, Ian organization: Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland Private Bag, 92019, Auckland, New Zealand – sequence: 7 givenname: Keh-Sung surname: Tsai fullname: Tsai, Keh-Sung organization: Department of Internal Medicine, National Taiwan University Hospital, Taipei, 10048, Taiwan – sequence: 8 givenname: Toshio surname: Matsumoto fullname: Matsumoto, Toshio organization: Fujii Memorial Institute of Medical Sciences, University of Tokushima, Japan – sequence: 9 givenname: Leilani B surname: Mercado-Asis fullname: Mercado-Asis, Leilani B organization: Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines – sequence: 10 givenname: Ding-Cheng surname: Chan fullname: Chan, Ding-Cheng organization: Superintendent Office, National Taiwan University Hospital Chu-Tung Branch, Zhudong, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Chu-Tung, Taiwan; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Chu-Tung, Taiwan – sequence: 11 givenname: Jawl-Shan surname: Hwang fullname: Hwang, Jawl-Shan organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Linkou, Taiwan – sequence: 12 givenname: Ching-Lung surname: Cheung fullname: Cheung, Ching-Lung organization: Department of Pharmacology and Pharmacy, Centre for Genomic Sciences, The University of Hong Kong, Pokfulam, Hong Kong – sequence: 13 givenname: Kenneth surname: Saag fullname: Saag, Kenneth organization: Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA – sequence: 14 givenname: Joon-Kiong surname: Lee fullname: Lee, Joon-Kiong organization: Beacon International Specialist Centre, Petaling Jaya, Malaysia – sequence: 15 givenname: Shih-Te surname: Tu fullname: Tu, Shih-Te organization: Division of Endocrinology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan – sequence: 16 givenname: Weibo surname: Xia fullname: Xia, Weibo organization: Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. Beijing, 100730 China – sequence: 17 givenname: Wei surname: Yu fullname: Yu, Wei organization: Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College. Beijing, 100730, China – sequence: 18 givenname: Yoon-Sok surname: Chung fullname: Chung, Yoon-Sok organization: Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, 16499, South Korea – sequence: 19 givenname: Peter surname: Ebeling fullname: Ebeling, Peter organization: Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, 3168, Australia – sequence: 20 givenname: Ambrish surname: Mithal fullname: Mithal, Ambrish organization: Division of Endocrinology and Diabetes, Medanta, the Medicity, Gurgaon, Pin: 122001, India – sequence: 21 givenname: Serge Livio surname: Ferrari fullname: Ferrari, Serge Livio organization: Department of Medicine, University Hospital of Geneva, Switzerland – sequence: 22 givenname: Cyrus surname: Cooper fullname: Cooper, Cyrus organization: Oxford National Institute for Health Biomedical Research Centre, University of Oxford, Windmill Road, Oxford, United Kingdom – sequence: 23 givenname: Gau-Tyan surname: Lin fullname: Lin, Gau-Tyan organization: Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan – sequence: 24 givenname: Rong-Sen surname: Yang fullname: Yang, Rong-Sen email: rsyang@ntuh.gov.tw organization: Department of Orthopaedics, College of Medicine, National Taiwan University & Hospital, Taipei, Taiwan. Electronic address: rsyang@ntuh.gov.tw |
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| SubjectTerms | Biomarkers Bone Density Bone Remodeling Collagen Type I Consensus Hip Fractures Humans Osteoporosis - diagnostic imaging Osteoporosis - drug therapy Peptide Fragments Procollagen |
| Title | Consensus Statement on the Use of Bone Turnover Markers for Short-Term Monitoring of Osteoporosis Treatment in the Asia-Pacific Region |
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