Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review

•Genomic alterations in PDAC represent potential targeting opportunities to individualize therapy.•Attempts to target key somatic driver mutations in PDAC have been unsuccessful.•DNA-damage repair gene mutations confer vulnerability to platinum agents and PARP-inhibitors.•Microsatellite unstable PDA...

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Bibliographic Details
Published in:	Cancer treatment reviews Vol. 75; pp. 27 - 38
Main Authors:	Singh, Ritu R., Goldberg, Johanna, Varghese, Anna M., Yu, Kenneth H., Park, Wungki, O'Reilly, Eileen M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.05.2019
Subjects:	Animals Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics DNA damage repair DNA Repair - drug effects DNA Repair - genetics Genomic alteration (GA) Genomics - methods Germline mutation Humans Microsatellite instability Mismatch repair (MMR) Pancreatic ductal adenocarcinoma (PDAC) Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use Somatic mutation Somatic mutation Mismatch repair (MMR) DNA damage repair Pancreatic ductal adenocarcinoma (PDAC) Genomic alteration (GA) Germline mutation Microsatellite instability
ISSN:	0305-7372, 1532-1967, 1532-1967
Online Access:	Get full text
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