Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression

Activated mast cells have been identified in the intima and perivascular tissue of human atherosclerotic plaques. As mast cells have been described to release a number of chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a pivotal role in leukocyte recruitment d...

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Bibliographic Details
Published in:	Atherosclerosis Vol. 241; no. 2; pp. 289 - 296
Main Authors:	Wezel, Anouk, Lagraauw, H. Maxime, van der Velden, Daniël, de Jager, Saskia C.A., Quax, Paul H.A., Kuiper, Johan, Bot, Ilze
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.08.2015
Subjects:	Animals Aorta - immunology Aorta - metabolism Aorta - pathology Aortic Diseases - genetics Aortic Diseases - immunology Aortic Diseases - metabolism Aortic Diseases - pathology Apolipoproteins E - deficiency Apolipoproteins E - genetics Atherosclerosis - genetics Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerotic plaque development and progression Cardiovascular Cells, Cultured Chemokine CXCL1 - immunology Chemokine CXCL1 - metabolism Chemokine CXCL12 - immunology Chemokine CXCL12 - metabolism Chemokines Disease Models, Animal Disease Progression Immunoglobulin E - administration & dosage Immunoglobulin E - immunology Influx Male Mast cells Mast Cells - drug effects Mast Cells - immunology Mast Cells - pathology Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration - drug effects Neutrophils Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Paracrine Communication Plaque, Atherosclerotic Receptors, CXCR4 - immunology Receptors, CXCR4 - metabolism Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - immunology Receptors, Interleukin-8B - metabolism Recruitment Signal Transduction Atherosclerotic plaque development and progression Influx Mast cells Chemokines Neutrophils Recruitment
ISSN:	0021-9150, 1879-1484, 1879-1484
Online Access:	Get full text
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