Rational Design of Self-Emulsifying Pellet Formulation of Thymol: Technology Development Guided by Molecular-Level Structure Characterization and Ex Vivo Testing

The growing need for processing natural lipophilic and often volatile substances such as thymol, a promising candidate for topical treatment of intestinal mucosa, led us to the utilization of solid-state nuclear magnetic resonance (ss-NMR) spectroscopy for the rational design of enteric pellets with...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 14; no. 8; p. 1545
Main Authors:	Macku, Jan, Kubova, Katerina, Urbanova, Martina, Muselik, Jan, Franc, Ales, Koutna, Gabriela, Pavelkova, Miroslava, Vetchy, David, Masek, Josef, Maskova, Eliska, Brus, Jiri
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 25.07.2022 MDPI
Subjects:	Bioavailability Bowel disease Care and treatment Cellulose Chemical properties Colorectal diseases COVID-19 Dosage and administration Drug delivery systems Drug dosages Drug therapy Drugs ex vivo testing Gastrointestinal agents Gastrointestinal diseases Health aspects Pharmaceutical industry Pharmaceutical research Pharmacokinetics Phenols rational design self-emulsifying pellet solid-state NMR structure Surfactants thymol Vehicles Czech Republic United States > US Germany rational design thymol ex vivo testing solid-state NMR self-emulsifying pellet structure
ISSN:	1999-4923, 1999-4923
Online Access:	Get full text
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