Bacteraemic pneumococcal pneumonia and SARS-CoV-2 pneumonia: differences and similarities

•In-hospital course and 30-day survival were compared between patients with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pneumonia and bacteraemic pneumococcal community-acquired pneumonia (B-PCAP).•B-PCAP was associated with more severe disease on admission and a higher intensive ca...

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Vydané v:International journal of infectious diseases Ročník 115; s. 39 - 47
Hlavní autori: Serrano Fernández, Leyre, Ruiz Iturriaga, Luis Alberto, España Yandiola, Pedro Pablo, Méndez Ocaña, Raúl, Pérez Fernández, Silvia, Tabernero Huget, Eva, Uranga Echeverria, Ane, Gonzalez Jimenez, Paula, García Hontoria, Patricia, Torres Martí, Antoni, Menendez Villanueva, Rosario, Zalacain Jorge, Rafael
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Canada Elsevier Ltd 01.02.2022
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases
Elsevier
Predmet:
Bacteraemic pneumococcal pneumonia
Community-acquired pneumonia
COVID-19
Humans
Intensive Care Units
Mortality
Pneumonia, Pneumococcal - complications
Process of care
Respiration, Artificial
SARS-CoV-2
Survival
CRP
OR
CURB-65
CI
Mortality
PSI
Community-acquired pneumonia
Survival
Process of care
COVID-19
B-PCAP
SARS-CoV-2
CAP
IMV
RT-PCR
AEMPS
ICU
SEPAR
Bacteraemic pneumococcal pneumonia
COPD
ISSN:1201-9712, 1878-3511, 1878-3511
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Shrnutí:•In-hospital course and 30-day survival were compared between patients with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pneumonia and bacteraemic pneumococcal community-acquired pneumonia (B-PCAP).•B-PCAP was associated with more severe disease on admission and a higher intensive care unit admission rate compared with SARS-CoV-2 pneumonia.•The mortality rate for SARS-CoV-2 pneumonia was higher and deaths occurred later compared with B-PCAP.•Pneumonia severity scales underestimate the risk of death in patients with SARS-CoV-2 pneumonia. To analyse differences in clinical presentation and outcome between bacteraemic pneumococcal community-acquired pneumonia (B-PCAP) and sSvere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pneumonia. This observational multi-centre study was conducted on patients hospitalized with B-PCAP between 2000 and 2020 and SARS-CoV-2 pneumonia in 2020. Thirty-day survival, predictors of mortality, and intensive care unit (ICU) admission were compared. In total, 663 patients with B-PCAP and 1561 patients with SARS-CoV-2 pneumonia were included in this study. Patients with B-PCAP had more severe disease, a higher ICU admission rate and more complications. Patients with SARS-CoV-2 pneumonia had higher in-hospital mortality (10.8% vs 6.8%; P=0.004). Among patients admitted to the ICU, the need for invasive mechanical ventilation (69.7% vs 36.2%; P<0.001) and mortality were higher in patients with SARS-CoV-2 pneumonia. In patients with B-PCAP, the predictive model found associations between mortality and systemic complications (hyponatraemia, septic shock and neurological complications), lower respiratory reserve and tachypnoea; chest pain and purulent sputum were protective factors in these patients. In patients with SARS-CoV-2 pneumonia, mortality was associated with previous liver and cardiac disease, advanced age, altered mental status, tachypnoea, hypoxaemia, bilateral involvement, pleural effusion, septic shock, neutrophilia and high blood urea nitrogen; in contrast, ≥7 days of symptoms was a protective factor in these patients. In-hospital mortality occurred earlier in patients with B-PCAP. Although B-PCAP was associated with more severe disease and a higher ICU admission rate, the mortality rate was higher for SARS-CoV-2 pneumonia and deaths occurred later. New prognostic scales and more effective treatments are needed for patients with SARS-CoV-2 pneumonia. [Display omitted]
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These authors contributed equally as senior authors.
ISSN:1201-9712
1878-3511
1878-3511
DOI:10.1016/j.ijid.2021.11.023