Cav1 suppresses tumor growth and metastasis in a murine model of cutaneous SCC through modulation of MAPK/AP-1 activation

Caveolin-1 (Cav1) is a scaffolding protein that serves to regulate the activity of several signaling molecules. Its loss has been implicated in the pathogenesis of several types of cancer, but its role in the development and progression of cutaneous squamous cell carcinoma (cSCC) remains largely une...

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Vydáno v:	The American journal of pathology Ročník 182; číslo 3; s. 992
Hlavní autoři:	Trimmer, Casey, Bonuccelli, Gloria, Katiyar, Sanjay, Sotgia, Federica, Pestell, Richard G, Lisanti, Michael P, Capozza, Franco
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.03.2013
Témata:	Animals Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Caveolin 1 - metabolism Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Disease Models, Animal Enzyme Activation - drug effects Epidermal Growth Factor - pharmacology Gene Knockdown Techniques Humans Keratin-18 - metabolism Keratinocytes - pathology MAP Kinase Signaling System - drug effects Mice Mice, Inbred BALB C Mice, Nude Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Models, Biological Neoplasm Invasiveness Neoplasm Metastasis Serum Skin Neoplasms - enzymology Skin Neoplasms - pathology Transcription Factor AP-1 - metabolism
ISSN:	1525-2191, 1525-2191
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