TRIP13 regulates DNA repair pathway choice through REV7 conformational change

DNA double-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2-deficient cancer cells cannot perform HDR, conferring sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPi). However, concomitant loss of the pro-NHEJ factors 53B...

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Bibliographic Details
Published in:	Nature cell biology Vol. 22; no. 1; pp. 87 - 96
Main Authors:	Clairmont, Connor S, Sarangi, Prabha, Ponnienselvan, Karthikeyan, Galli, Lucas D, Csete, Isabelle, Moreau, Lisa, Adelmant, Guillaume, Chowdhury, Dipanjan, Marto, Jarrod A, D'Andrea, Alan D
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.01.2020
Subjects:	Adenosine diphosphate Adenosine triphosphatase Anemia ATPases Associated with Diverse Cellular Activities - drug effects ATPases Associated with Diverse Cellular Activities - genetics BRCA1 protein BRCA1 Protein - deficiency Breast cancer Cell Cycle Proteins - drug effects Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Crosslinking Deoxyribonucleic acid Dismantling DNA DNA damage DNA Damage - drug effects DNA End-Joining Repair - genetics DNA polymerase DNA repair DNA Repair - drug effects DNA Repair - genetics DNA Replication - drug effects DNA Replication - genetics DNA-directed DNA polymerase Homology Humans Mad2 Proteins - genetics Non-homologous end joining Poly(ADP-ribose) Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Recombinational DNA Repair - genetics Repair Ribose Telomere-Binding Proteins - drug effects Telomere-Binding Proteins - genetics
ISSN:	1465-7392, 1476-4679, 1476-4679
Online Access:	Get full text
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