Transcriptomics of Marburg virus-infected primary proximal tubular cells reveals negative correlation of immune response and energy metabolism

•Marburg virus infects and replicates in primary human proximal tubular cells (PTC).•Transcriptome analyses at multiple time points revealed a profound inflammatory response by IFNα, -y and TNFα signaling.•Among the strongly downregulated gene sets were targets of the transcription factors MYC and E...

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Veröffentlicht in:	Virus research Jg. 342; S. 199337
Hauptverfasser:	Koch, Benjamin, Filzmayer, Maximilian, Patyna, Sammy, Wetzstein, Nils, Lampe, Sebastian, Schmid, Tobias, Geiger, Helmut, Baer, Patrick C., Dolnik, Olga
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.04.2024 Elsevier
Schlagworte:	Acute kidney injury cholesterol homeostasis DNA repair etiological agents fever gene expression genes Human primary proximal tubular cells humans immune response inflammation kidneys Lake Victoria Marburg marburgvirus Marburg virus mortality oxidative phosphorylation pathogenesis PGC-1α transcriptomics virus replication viruses Lake Victoria Human primary proximal tubular cells PGC-1α Marburg virus Acute kidney injury acute kidney injury human primary proximal tubular cells
ISSN:	0168-1702, 1872-7492, 1872-7492
Online-Zugang:	Volltext
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