Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children

Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components...

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Veröffentlicht in:The journal of allergy and clinical immunology in practice (Cambridge, MA) Jg. 5; H. 5; S. 1325
Hauptverfasser: Andorf, Sandra, Borres, Magnus P, Block, Whitney, Tupa, Dana, Bollyky, Jennifer B, Sampath, Vanitha, Elizur, Arnon, Lidholm, Jonas, Jones, Joseph E, Galli, Stephen J, Chinthrajah, Rebecca S, Nadeau, Kari C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.09.2017
Schlagworte:
Adolescent
Allergens - immunology
Child
Child, Preschool
Cross Reactions
Egg Proteins - immunology
Female
Food Hypersensitivity - immunology
Humans
Immunoglobulin E - blood
Male
Milk Proteins - immunology
Molecular Mimicry
Prunus dulcis - immunology
Skin Tests
Double-blind, placebo-controlled food challenge
Multifood allergy
IgE
Component-resolved testing
ISSN:2213-2201, 2213-2201
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Zusammenfassung:Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs). Sixty participants with multiple food allergies were characterized by clinical history, DBPCFCs, total IgE, specific IgE, and component-resolved diagnostics (IgE and IgG4) data. The food allergens tested were almond, egg, milk, sesame, peanut, pecan, walnut, hazelnut, cashew, pistachio, soy, and wheat. Our data demonstrate that of the reactions observed during a graded DBPCFC, gastrointestinal reactions occurred more often in boys than in girls, as well as in individuals with high levels of IgE to 2S albumins from cashew, walnut, and hazelnut. Certain food allergies often occurred concomitantly in individuals (ie, cashew/pistachio and walnut/pecan/hazelnut). IgE testing to components further corroborated serological relationships between and among these clustered food allergies. Associations of certain food allergies were shown by DBPCFC outcomes as well as by correlations in IgE reactivity to structurally related food allergen components. Each of these criteria independently demonstrated a significant association between allergies to cashew and pistachio, as well as among allergies to walnut, pecan, and hazelnut.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2213-2201
2213-2201
DOI:10.1016/j.jaip.2017.01.016