Concise Synthesis of the Antiplasmodial Isocyanoterpene 7,20‐Diisocyanoadociane

The flagship member of the antiplasmodial isocyanoterpenes, 7,20‐diisocyanoadociane (DICA), was synthesized from dehydrocryptone in 10 steps, and in 13 steps from commercially available material. Our previous formal synthesis was reengineered, leveraging only productive transformations to deliver DI...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 58; no. 39; pp. 13749 - 13752
Main Authors:	Karns, Alexander S., Ellis, Bryan D., Roosen, Philipp C., Chahine, Zeinab, Le Roch, Karine G., Vanderwal, Christopher D.
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 23.09.2019 Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	antiplasmodial Antiprotozoal agents Birch reduction Chemistry Chemistry, Multidisciplinary Cyclohexanone Methylation Physical Sciences Reengineering (product) Science & Technology stereocontrol Stereoisomers Synthesis terpenoids total synthesis terpenoids stereocontrol Birch reduction ANTIMALARIAL ACTIVITY ALKYLATION REACTIONS ORGANOMAGNESIUM total synthesis ISONITRILES antiplasmodial ORGANOALUMINUM ADDITION
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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