Modern Synthetic Avenues for the Preparation of Functional Fluorophores

Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemi...

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Vydáno v:Angewandte Chemie International Edition Ročník 56; číslo 14; s. 3758 - 3769
Hlavní autoři: de Moliner, Fabio, Kielland, Nicola, Lavilla, Rodolfo, Vendrell, Marc
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany Wiley Subscription Services, Inc 27.03.2017
John Wiley and Sons Inc
Vydání:International ed. in English
Témata:
Biomolecules
Chemical compounds
Chemical reactions
C−H activation
Fluorescence
fluorescent probes
Fluorophores
imaging
microscopy
Minireview
Minireviews
multicomponent reactions
multicomponent reactions
microscopy
C−H activation
imaging
fluorescent probes
ISSN:1433-7851, 1521-3773, 1521-3773
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Popis
Shrnutí:Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemical processes have been developed in the past few years. In this Minireview, we describe the most recent advances in the design, preparation, and fine‐tuning of fluorophores by means of multicomponent reactions, C−H activation processes, cycloadditions, and biomolecule‐based chemical transformations. Functional fluorophores enable the fast and accurate profiling of specific biomolecules but these sophisticated structures are often difficult to access through conventional synthetic strategies. Recent advances in the design, preparation, and fine‐tuning of fluorophores by means of multicomponent reactions, C−H activation processes, cycloadditions, and biomolecule‐based chemical transformations are discussed.
Bibliografie:ObjectType-Article-1
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201609394