Modern Synthetic Avenues for the Preparation of Functional Fluorophores

Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemi...

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Bibliographic Details
Published in:Angewandte Chemie International Edition Vol. 56; no. 14; pp. 3758 - 3769
Main Authors: de Moliner, Fabio, Kielland, Nicola, Lavilla, Rodolfo, Vendrell, Marc
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 27.03.2017
John Wiley and Sons Inc
Edition:International ed. in English
Subjects:
Biomolecules
Chemical compounds
Chemical reactions
C−H activation
Fluorescence
fluorescent probes
Fluorophores
imaging
microscopy
Minireview
Minireviews
multicomponent reactions
multicomponent reactions
microscopy
C−H activation
imaging
fluorescent probes
ISSN:1433-7851, 1521-3773, 1521-3773
Online Access:Get full text
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Summary:Biomedical research relies on the fast and accurate profiling of specific biomolecules and cells in a non‐invasive manner. Functional fluorophores are powerful tools for such studies. As these sophisticated structures are often difficult to access through conventional synthetic strategies, new chemical processes have been developed in the past few years. In this Minireview, we describe the most recent advances in the design, preparation, and fine‐tuning of fluorophores by means of multicomponent reactions, C−H activation processes, cycloadditions, and biomolecule‐based chemical transformations. Functional fluorophores enable the fast and accurate profiling of specific biomolecules but these sophisticated structures are often difficult to access through conventional synthetic strategies. Recent advances in the design, preparation, and fine‐tuning of fluorophores by means of multicomponent reactions, C−H activation processes, cycloadditions, and biomolecule‐based chemical transformations are discussed.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.201609394