Designed Spiroketal Protein Modulation

Spiroketals are structural motifs found in many biologically active natural products, which has stimulated considerable efforts toward their synthesis and interest in their use as drug lead compounds. Despite this, the use of spiroketals, and especially bisbenzanulated spiroketals, in a structure‐ba...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 56; no. 20; pp. 5480 - 5484
Main Authors:	Scheepstra, Marcel, Andrei, Sebastian A., Unver, M. Yagiz, Hirsch, Anna K. H., Leysen, Seppe, Ottmann, Christian, Brunsveld, Luc, Milroy, Lech‐Gustav
Format:	Journal Article
Language:	English
Published:	WEINHEIM Wiley 08.05.2017 Wiley Subscription Services, Inc John Wiley and Sons Inc
Edition:	International ed. in English
Subjects:	Allosteric properties Biological activity Chemistry Chemistry, Multidisciplinary Communication Communications Crystal structure Crystallography, X-Ray drug design Drug discovery Furans - chemistry Humans Lead compounds Models, Molecular Molecular Structure Natural products Nuclear Receptor Coactivator 2 - chemistry Physical Sciences Proteins Receptors Retinoid X Receptor alpha - chemistry Retinoid X receptors Science & Technology spiro compounds Spiro Compounds - chemistry structure elucidation THERAPEUTICS RUBROMYCIN RECOGNITION drug design NUCLEAR RECEPTORS NATURAL-PRODUCTS BIOLOGY-ORIENTED SYNTHESIS spiro compounds RXR natural products drug discovery structure elucidation RETINOID-X-RECEPTOR SCAFFOLDS SELECTIVITY
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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