Estetrol‐Drospirenone combination oral contraceptive: a clinical study of contraceptive efficacy, bleeding pattern and safety in Europe and Russia
Objectives To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Design Multicenter, open‐label, phase 3 trial. Setting Sixty‐nine sites in Europe and Russia. Population Sexually active women ag...
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| Vydáno v: | BJOG : an international journal of obstetrics and gynaecology Ročník 129; číslo 1; s. 63 - 71 |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Wiley Subscription Services, Inc
01.01.2022
John Wiley and Sons Inc |
| Témata: | |
| ISSN: | 1470-0328, 1471-0528, 1471-0528 |
| On-line přístup: | Získat plný text |
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| Abstract | Objectives
To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg.
Design
Multicenter, open‐label, phase 3 trial.
Setting
Sixty‐nine sites in Europe and Russia.
Population
Sexually active women aged 18–50 years with regular menstrual cycles and body mass index ≤35 kg/m2.
Methods
E4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary.
Main outcome measures
Pearl Index (PI) for women 18–35 years (overall and method‐failure), bleeding pattern and AEs.
Results
A total of 1553 women aged 18–50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman‐years (95% CI 0.15–1.11); method failure PI was 0.29 pregnancies/100 woman‐years (95% CI 0.06–0.83). Scheduled bleeding/spotting occurred in 91.9–94.4% of women over Cycles 1 to 12 and lasted a median of 4–5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment‐related serious AE was reported, a lower extremity venous thromboembolism. One‐hundred and forty‐one (9.1%) women discontinued study participation because of treatment‐related adverse events.
Conclusion
E4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile.
Tweetable
A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile.
Tweetable
A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile.
This article includes Author Insights, a video available at: https://vimeo.com/bjog/authorinsights16840 |
|---|---|
| AbstractList | To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg.OBJECTIVESTo assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg.Multicenter, open-label, phase 3 trial.DESIGNMulticenter, open-label, phase 3 trial.Sixty-nine sites in Europe and Russia.SETTINGSixty-nine sites in Europe and Russia.Sexually active women aged 18-50 years with regular menstrual cycles and body mass index ≤35 kg/m2 .POPULATIONSexually active women aged 18-50 years with regular menstrual cycles and body mass index ≤35 kg/m2 .E4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary.METHODSE4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary.Pearl Index (PI) for women 18-35 years (overall and method-failure), bleeding pattern and AEs.MAIN OUTCOME MEASURESPearl Index (PI) for women 18-35 years (overall and method-failure), bleeding pattern and AEs.A total of 1553 women aged 18-50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman-years (95% CI 0.15-1.11); method failure PI was 0.29 pregnancies/100 woman-years (95% CI 0.06-0.83). Scheduled bleeding/spotting occurred in 91.9-94.4% of women over Cycles 1 to 12 and lasted a median of 4-5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment-related serious AE was reported, a lower extremity venous thromboembolism. One-hundred and forty-one (9.1%) women discontinued study participation because of treatment-related adverse events.RESULTSA total of 1553 women aged 18-50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman-years (95% CI 0.15-1.11); method failure PI was 0.29 pregnancies/100 woman-years (95% CI 0.06-0.83). Scheduled bleeding/spotting occurred in 91.9-94.4% of women over Cycles 1 to 12 and lasted a median of 4-5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment-related serious AE was reported, a lower extremity venous thromboembolism. One-hundred and forty-one (9.1%) women discontinued study participation because of treatment-related adverse events.E4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile.CONCLUSIONE4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile.A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile.TWEETABLE ABSTRACTA phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. This article includes Author Insights, a video abstract available at: https://vimeo.com/bjog/authorinsights16840 To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Multicenter, open-label, phase 3 trial. Sixty-nine sites in Europe and Russia. Sexually active women aged 18-50 years with regular menstrual cycles and body mass index ≤35 kg/m . E4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary. Pearl Index (PI) for women 18-35 years (overall and method-failure), bleeding pattern and AEs. A total of 1553 women aged 18-50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman-years (95% CI 0.15-1.11); method failure PI was 0.29 pregnancies/100 woman-years (95% CI 0.06-0.83). Scheduled bleeding/spotting occurred in 91.9-94.4% of women over Cycles 1 to 12 and lasted a median of 4-5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment-related serious AE was reported, a lower extremity venous thromboembolism. One-hundred and forty-one (9.1%) women discontinued study participation because of treatment-related adverse events. E4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile. A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. Objectives To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg. Design Multicenter, open‐label, phase 3 trial. Setting Sixty‐nine sites in Europe and Russia. Population Sexually active women aged 18–50 years with regular menstrual cycles and body mass index ≤35 kg/m2. Methods E4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary. Main outcome measures Pearl Index (PI) for women 18–35 years (overall and method‐failure), bleeding pattern and AEs. Results A total of 1553 women aged 18–50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman‐years (95% CI 0.15–1.11); method failure PI was 0.29 pregnancies/100 woman‐years (95% CI 0.06–0.83). Scheduled bleeding/spotting occurred in 91.9–94.4% of women over Cycles 1 to 12 and lasted a median of 4–5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment‐related serious AE was reported, a lower extremity venous thromboembolism. One‐hundred and forty‐one (9.1%) women discontinued study participation because of treatment‐related adverse events. Conclusion E4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile. Tweetable A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. Tweetable A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. This article includes Author Insights, a video available at: https://vimeo.com/bjog/authorinsights16840 ObjectivesTo assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg.DesignMulticenter, open‐label, phase 3 trial.SettingSixty‐nine sites in Europe and Russia.PopulationSexually active women aged 18–50 years with regular menstrual cycles and body mass index ≤35 kg/m2.MethodsE4/DRSP was administered in a 24 active/4 placebo regimen for up to 13 cycles. Visits were scheduled during Cycles 2, 4, 7 and 10 and after completing treatment during which adverse events (AEs) were collected. Participants recorded medication intake, vaginal bleeding/spotting, use of other contraceptive methods and sexual intercourse on a daily diary.Main outcome measuresPearl Index (PI) for women 18–35 years (overall and method‐failure), bleeding pattern and AEs.ResultsA total of 1553 women aged 18–50 years, including 1353 from 18 to 35 years old, received the study medication. PI was 0.47 pregnancies/100 woman‐years (95% CI 0.15–1.11); method failure PI was 0.29 pregnancies/100 woman‐years (95% CI 0.06–0.83). Scheduled bleeding/spotting occurred in 91.9–94.4% of women over Cycles 1 to 12 and lasted a median of 4–5 days per cycle. The percentage of women with unscheduled bleeding/spotting episodes decreased from 23.5% in Cycle 1 to <16% from Cycle 6 onwards. The most common AEs were headache (7.7%), metrorrhagia (5.5%), vaginal haemorrhage (4.8%) and acne (4.2%). One treatment‐related serious AE was reported, a lower extremity venous thromboembolism. One‐hundred and forty‐one (9.1%) women discontinued study participation because of treatment‐related adverse events.ConclusionE4/DRSP provides effective contraception, a predictable bleeding pattern and a favourable safety profile.Tweetable abstractA phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. This article includes Author Insights, a video abstract available at: https://vimeo.com/bjog/authorinsights16840 |
| Author | Apter, D Apolikhina, I Jost, M Foidart, J‐M Zatik, J Weyers, S Suturina, L Gemzell‐Danielsson, K Creinin, MD Piltonen, T |
| AuthorAffiliation | 3 Gynaecological Praxis St Anna Debrecen Hungary 4 Department of Obstetrics and Gynaecology University Hospital Gent Belgium 10 Department of Obstetrics and Gynaecology University of Liège Liège Belgium 2 VL‐Medi Clinical Research Centre Helsinki Finland 5 Department of Obstetrics and Gynaecology PEDEGO Research Unit Medical Research Center Oulu University Hospital University of Oulu Oulu Finland 6 Scientific Centre for Family Health and Human Reproduction Problems Irkutsk Russia 7 Kulakov National Medical Research Centre for Obstetrics, Gynaecology, and Perinatology Moscow Russia 9 Department of Obstetrics and Gynecology University of California Davis, Sacramento CA USA 8 Estetra SRL, an affiliate Company of Mithra Pharmaceuticals Liège Belgium 1 Department of Women's and Children's Health Karolinska Institutet Karolinska University Hospital Stockholm Sweden |
| AuthorAffiliation_xml | – name: 4 Department of Obstetrics and Gynaecology University Hospital Gent Belgium – name: 9 Department of Obstetrics and Gynecology University of California Davis, Sacramento CA USA – name: 2 VL‐Medi Clinical Research Centre Helsinki Finland – name: 8 Estetra SRL, an affiliate Company of Mithra Pharmaceuticals Liège Belgium – name: 6 Scientific Centre for Family Health and Human Reproduction Problems Irkutsk Russia – name: 7 Kulakov National Medical Research Centre for Obstetrics, Gynaecology, and Perinatology Moscow Russia – name: 3 Gynaecological Praxis St Anna Debrecen Hungary – name: 5 Department of Obstetrics and Gynaecology PEDEGO Research Unit Medical Research Center Oulu University Hospital University of Oulu Oulu Finland – name: 1 Department of Women's and Children's Health Karolinska Institutet Karolinska University Hospital Stockholm Sweden – name: 10 Department of Obstetrics and Gynaecology University of Liège Liège Belgium |
| Author_xml | – sequence: 1 givenname: K orcidid: 0000-0001-6516-1444 surname: Gemzell‐Danielsson fullname: Gemzell‐Danielsson, K organization: Karolinska University Hospital – sequence: 2 givenname: D surname: Apter fullname: Apter, D organization: VL‐Medi Clinical Research Centre – sequence: 3 givenname: J surname: Zatik fullname: Zatik, J organization: Gynaecological Praxis St Anna – sequence: 4 givenname: S surname: Weyers fullname: Weyers, S organization: University Hospital – sequence: 5 givenname: T surname: Piltonen fullname: Piltonen, T organization: University of Oulu – sequence: 6 givenname: L surname: Suturina fullname: Suturina, L organization: Scientific Centre for Family Health and Human Reproduction Problems – sequence: 7 givenname: I surname: Apolikhina fullname: Apolikhina, I organization: Kulakov National Medical Research Centre for Obstetrics, Gynaecology, and Perinatology – sequence: 8 givenname: M surname: Jost fullname: Jost, M email: mjost@mithra.com organization: Estetra SRL, an affiliate Company of Mithra Pharmaceuticals – sequence: 9 givenname: MD surname: Creinin fullname: Creinin, MD organization: University of California – sequence: 10 givenname: J‐M surname: Foidart fullname: Foidart, J‐M organization: University of Liège |
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| Cites_doi | 10.1080/ejc.8.2.87.92 10.1016/j.contraception.2006.12.018 10.15252/emmm.201404112 10.1016/j.contraception.2016.04.015 10.1152/physrev.00024.2016 10.1016/j.genhosppsych.2004.06.003 10.1530/EJE-14-0527 10.1136/jfprhc-2013-100605 10.1097/GRF.0b013e318159bf8a 10.1136/bmj.f5298 10.1080/13625187.2017.1336532 10.3109/09513590.2012.662547 10.1016/j.contraception.2016.08.018 10.1161/JAHA.118.008950 10.1016/j.contraception.2009.03.018 10.1080/13625187.2020.1743828 10.1016/j.contraception.2021.05.002 10.1093/humupd/dmw016 10.1136/bmj.e4944 10.1530/acta.0.0490207 10.1016/j.ejogrb.2009.11.001 10.3109/13625187.2015.1044082 10.3109/09513590.2016.1161743 10.1530/JOE-14-0549 10.1136/bmj.d6423 10.1016/j.contraception.2006.08.012 |
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| Copyright | 2021 Estetra SRL. : published by John Wiley & Sons Ltd. 2021 Estetra SRL. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. 2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| Keywords | combined oral contraception estetrol contraceptive efficacy safety native estrogen drospirenone Bleeding pattern |
| Language | English |
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| References_xml | – volume: 347 start-page: f5298 year: 2013 article-title: Different combined oral contraceptives and the risk of venous thrombosis: systematic review and network meta‐analysis publication-title: BMJ – volume: 3 issue: 1 year: 2019 article-title: Estetrol (E4) is a unique estrogen with selective actions in tissues which are distinctly different from the actions of SERMs publication-title: J Endocrine Soc – volume: 39 start-page: 211 year: 2013 end-page: 6 article-title: Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen publication-title: J Fam Plann Reprod Health Care – volume: 49 start-page: 207 year: 1965 end-page: 20 article-title: Metabolism of 17‐beta‐oestradiol‐4‐14‐C in early infancy publication-title: Acta Endocrinol (Copenh) – volume: 50 start-page: 850 year: 2007 end-page: 67 article-title: Study design to evaluate the safety and effectiveness of hormonal contraception for women publication-title: Clin Obstet Gynecol – volume: 25 start-page: 221 year: 2020 end-page: 27 article-title: Oestrogen‐free oral contraception with a 4 mg drospirenone‐only pill: new data and a review of the literature publication-title: Eur J Contracept Reprod Health Care – volume: 345 year: 2012 article-title: Assessing the risk of venous thromboembolic events in women taking progestin‐only contraception: a meta‐analysis publication-title: BMJ – volume: 22 start-page: 260 year: 2017 end-page: 67 article-title: Estetrol combined with drospirenone: an oral contraceptive with high acceptability, user satisfaction, well‐being and favourable body weight control publication-title: Eur J Contracept Reprod Health Care – volume: 8 start-page: 87 year: 2003 end-page: 92 article-title: Recommendation for confidence interval and sample size calculation for the Pearl Index publication-title: Eur J Contracept Reprod Health Care – volume: 6 start-page: 1328 year: 2014 end-page: 46 article-title: The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor alpha modulation, uncoupling nuclear and membrane activation publication-title: EMBO Mol Med – start-page: 15 year: 2009 end-page: 44 – volume: 26 start-page: 481 year: 2004 end-page: 3 article-title: Venous thromboembolism and escitalopram publication-title: Gen Hosp Psychiatry – volume: 63 start-page: 299 year: 2011 end-page: 304 article-title: Pharmacological profile of estrogens in oral contraception publication-title: Minerva Ginecol – volume: 343 start-page: d6423 year: 2011 article-title: Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001–9 publication-title: BMJ – volume: 94 start-page: 366 year: 2016 end-page: 73 article-title: Bleeding pattern and cycle control with estetrol‐containing combined oral contraceptives: results from a phase II, randomised, dose‐finding study (FIESTA) publication-title: Contraception – volume: 75 start-page: 11 year: 2007 end-page: 5 article-title: Recommendations for standardization of data collection and analysis of bleeding in combined hormone contraceptive trials publication-title: Contraception – volume: 95 start-page: 140 year: 2017 end-page: 47 article-title: Reduced haemostatic effects with drospirenone‐based oral contraceptives containing estetrol versus ethinyl estradiol publication-title: Contraception – volume: 20 start-page: 476 year: 2015 end-page: 89 article-title: Inhibition of ovulation by administration of estetrol in combination with drospirenone or levonorgestrel: results of a phase II dose‐finding pilot study publication-title: Eur J Contracept Reprod Health Care – volume: 104 start-page: 222 year: 2021 end-page: 28 article-title: Estetrol‐drospirenone combination oral contraceptive: North American phase 3 efficacy and safety results publication-title: Contraception – volume: 4 start-page: 52 year: 2007 end-page: 4 article-title: A case of pulmonary embolism associated with escitalopram publication-title: Psychiatr Invest – volume: 171 start-page: R221 year: 2014 end-page: 30 article-title: Epidemiology of hormonal contraceptives‐related venous thromboembolism publication-title: Eur J Endocrinol – volume: 28 start-page: 400 year: 2012 end-page: 8 article-title: An overview of the development of combined oral contraceptives containing estradiol: focus on estradiol valerate/dienogest publication-title: Gynecol Endocrinol – volume: 22 start-page: 634 year: 2016 end-page: 46 article-title: Hormonal contraceptives: pharmacology tailored to women's health publication-title: Hum Reprod Update – volume: 32 start-page: 749 year: 2016 end-page: 51 article-title: Drospirenone as estrogen‐free pill and hemostasis: coagulatory study results comparing a novel 4 mg formulation in a 24 + 4 cycle with desogestrel 75 mug per day publication-title: Gynecol Endocrinol – volume: 3 start-page: CD010813 year: 2014 article-title: Combined oral contraceptives: venous thrombosis publication-title: Cochrane Database Syst Rev. – volume: 80 start-page: 436 year: 2009 end-page: 44 article-title: Bleeding pattern and cycle control with an estradiol‐based oral contraceptive: a seven‐cycle, randomized comparative trial of estradiol valerate/dienogest and ethinyl estradiol/levonorgestrel publication-title: Contraception – volume: 224 start-page: 85 year: 2015 end-page: 95 article-title: Estetrol is a weak estrogen antagonizing estradiol‐dependent mammary gland proliferation publication-title: J Endocrinol – volume: 7 year: 2018 article-title: Predominant role of nuclear versus membrane estrogen receptor alpha in arterial protection: implications for estrogen receptor alpha modulation in cardiovascular prevention/safety publication-title: J Am Heart Assoc – volume: 20 start-page: 463 year: 2015 end-page: 75 article-title: Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives publication-title: Eur J Contracept Reprod Health Care – volume: 75 start-page: 328 year: 2007 end-page: 36 article-title: Range of published estimates of venous thromboembolism incidence in young women publication-title: Contraception – year: 2019 – volume: 149 start-page: 57 year: 2010 end-page: 62 article-title: Efficacy and safety of a novel oral contraceptive based on oestradiol (oestradiol valerate/dienogest): a Phase III trial publication-title: Eur J Obstet Gynecol Reprod Biol – volume: 97 start-page: 1045 year: 2017 end-page: 87 article-title: Membrane and nuclear estrogen receptor alpha actions: from tissue specificity to medical implications publication-title: Physiol Rev – volume: 4 start-page: 52 year: 2007 ident: e_1_2_7_27_1 article-title: A case of pulmonary embolism associated with escitalopram publication-title: Psychiatr Invest – volume: 3 start-page: CD010813 year: 2014 ident: e_1_2_7_4_1 article-title: Combined oral contraceptives: venous thrombosis publication-title: Cochrane Database Syst Rev. – volume: 3 issue: 1 year: 2019 ident: e_1_2_7_12_1 article-title: Estetrol (E4) is a unique estrogen with selective actions in tissues which are distinctly different from the actions of SERMs publication-title: J Endocrine Soc – ident: e_1_2_7_24_1 doi: 10.1080/ejc.8.2.87.92 – ident: e_1_2_7_33_1 doi: 10.1016/j.contraception.2006.12.018 – ident: e_1_2_7_9_1 doi: 10.15252/emmm.201404112 – start-page: 15 volume-title: Medical eligibility criteria for contraceptive use year: 2009 ident: e_1_2_7_23_1 – ident: e_1_2_7_17_1 doi: 10.1016/j.contraception.2016.04.015 – ident: e_1_2_7_10_1 doi: 10.1152/physrev.00024.2016 – ident: e_1_2_7_26_1 doi: 10.1016/j.genhosppsych.2004.06.003 – ident: e_1_2_7_3_1 doi: 10.1530/EJE-14-0527 – ident: e_1_2_7_7_1 doi: 10.1136/jfprhc-2013-100605 – ident: e_1_2_7_22_1 doi: 10.1097/GRF.0b013e318159bf8a – ident: e_1_2_7_5_1 doi: 10.1136/bmj.f5298 – ident: e_1_2_7_18_1 doi: 10.1080/13625187.2017.1336532 – ident: e_1_2_7_6_1 doi: 10.3109/09513590.2012.662547 – volume: 20 start-page: 463 year: 2015 ident: e_1_2_7_14_1 article-title: Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives publication-title: Eur J Contracept Reprod Health Care – ident: e_1_2_7_15_1 doi: 10.1016/j.contraception.2016.08.018 – ident: e_1_2_7_11_1 doi: 10.1161/JAHA.118.008950 – ident: e_1_2_7_30_1 doi: 10.1016/j.contraception.2009.03.018 – volume: 63 start-page: 299 year: 2011 ident: e_1_2_7_2_1 article-title: Pharmacological profile of estrogens in oral contraception publication-title: Minerva Ginecol – ident: e_1_2_7_28_1 doi: 10.1080/13625187.2020.1743828 – ident: e_1_2_7_21_1 – ident: e_1_2_7_19_1 doi: 10.1016/j.contraception.2021.05.002 – ident: e_1_2_7_29_1 doi: 10.1093/humupd/dmw016 – ident: e_1_2_7_34_1 doi: 10.1136/bmj.e4944 – ident: e_1_2_7_8_1 doi: 10.1530/acta.0.0490207 – ident: e_1_2_7_31_1 doi: 10.1016/j.ejogrb.2009.11.001 – ident: e_1_2_7_16_1 doi: 10.3109/13625187.2015.1044082 – ident: e_1_2_7_35_1 doi: 10.3109/09513590.2016.1161743 – ident: e_1_2_7_13_1 doi: 10.1530/JOE-14-0549 – volume-title: Establishing Effectiveness and Safety for Hormonal Drug Products Intended to Prevent Pregnancy year: 2019 ident: e_1_2_7_20_1 – ident: e_1_2_7_32_1 doi: 10.1136/bmj.d6423 – ident: e_1_2_7_25_1 doi: 10.1016/j.contraception.2006.08.012 |
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To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone... A phase 3 trial with E4/DRSP shows high contraceptive efficacy, a predictable bleeding pattern and favourable safety profile. This article includes Author... To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3 mg.... ObjectivesTo assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone... To assess the contraceptive efficacy, bleeding pattern and safety of a combined oral contraceptive containing estetrol (E4) 15 mg and drospirenone (DRSP) 3... |
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| SubjectTerms | Acne Adolescent Adult Adverse events Birth control Bleeding Bleeding pattern Body mass index combined oral contraception Contraception contraceptive efficacy Contraceptives, Oral, Combined - administration & dosage Contraceptives, Oral, Combined - adverse effects drospirenone Effectiveness estetrol Estetrol - administration & dosage Estetrol - adverse effects Europe Female Hemorrhage Humans Menstruation Metrorrhagia Middle Aged native estrogen Oral contraceptives Patient safety Russia Safety Sexual intercourse Thromboembolism Vagina Womens health Young Adult |
| Title | Estetrol‐Drospirenone combination oral contraceptive: a clinical study of contraceptive efficacy, bleeding pattern and safety in Europe and Russia |
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