The clinical role of the TME in solid cancer

The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts, and a variety of immune cells that control tumour growth and invasion. It is well established that anti-tumour immunit...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:British journal of cancer Ročník 120; číslo 1; s. 45 - 53
Hlavní autori: Giraldo, Nicolas A., Sanchez-Salas, Rafael, Peske, J. David, Vano, Yann, Becht, Etienne, Petitprez, Florent, Validire, Pierre, Ingels, Alexandre, Cathelineau, Xavier, Fridman, Wolf Herman, Sautès-Fridman, Catherine
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Nature Publishing Group UK 01.01.2019
Nature Publishing Group
Cancer Research UK
Predmet:
631/67/580/1884
692/4028/67/1059/2325
692/4028/67/327
692/53/2422
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Cancer-Associated Fibroblasts - immunology
Cancer-Associated Fibroblasts - pathology
Cell Proliferation - genetics
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Drug Resistance
Endothelial cells
Endothelial Cells - immunology
Endothelial Cells - pathology
Epidemiology
Fibroblasts
Humans
Immunotherapy
Kidney cancer
Life Sciences
Lymphocytes T
Melanoma
Metastases
Molecular Medicine
Neoplasm Invasiveness - genetics
Neoplasm Invasiveness - pathology
Neoplasms - immunology
Neoplasms - pathology
Oncology
Phenotypes
Renal cell carcinoma
Review
Review Article
Solid tumors
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - pathology
Tumor Microenvironment - immunology
Tumors
ISSN:0007-0920, 1532-1827, 1532-1827
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:The highly complex and heterogenous ecosystem of a tumour not only contains malignant cells, but also interacting cells from the host such as endothelial cells, stromal fibroblasts, and a variety of immune cells that control tumour growth and invasion. It is well established that anti-tumour immunity is a critical hurdle that must be overcome for tumours to initiate, grow and spread and that anti-tumour immunity can be modulated using current immunotherapies to achieve meaningful anti-tumour clinical responses. Pioneering studies in melanoma, ovarian and colorectal cancer have demonstrated that certain features of the tumour immune microenvironment (TME)—in particular, the degree of tumour infiltration by cytotoxic T cells—can predict a patient’s clinical outcome. More recently, studies in renal cell cancer have highlighted the importance of assessing the phenotype of the infiltrating T cells to predict early relapse. Furthermore, intricate interactions with non-immune cellular players such as endothelial cells and fibroblasts modulate the clinical impact of immune cells in the TME. Here, we review the critical components of the TME in solid tumours and how they shape the immune cell contexture, and we summarise numerous studies evaluating its clinical significance from a prognostic and theranostic perspective.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Literature Review-3
ObjectType-Review-3
content type line 23
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-018-0327-z