Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

The Mediator complex facilitates interactions between transcription factors and RNA polymerase II, a process that is required for host gene transcription, including in response to viral infections. Among the many subunits in the Mediator complex, the MED25 subunit has been shown to be a target for v...

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Veröffentlicht in:	Nature communications Jg. 16; H. 1; S. 2883 - 14
Hauptverfasser:	Kalita, Parismita, Khatavkar, Oam, Uwase, Grace, Korshunova, Yulia, Hu, Yuying, Wagner, Nicole D., Xu, Jian, Pan, Jiehong, Nix, Jay C., Gross, Michael L., Brody, Steven L., Borek, Dominika, Amarasinghe, Gaya K., Payton, Jacqueline E., Leung, Daisy W.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 25.03.2025 Nature Publishing Group Nature Portfolio
Schlagworte:	38/91 60 APPLIED LIFE SCIENCES 631/326/596/2557 631/45/612/1256 631/535/1266 82/16 82/80 82/83 96/109 Activating transcription factor 3 Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Crystal structure Crystallography, X-Ray DNA-directed RNA polymerase Gene regulation Heterogeneity Host-Pathogen Interactions Humanities and Social Sciences Humans Interfaces Mediator Complex - chemistry Mediator Complex - genetics Mediator Complex - metabolism Models, Molecular multidisciplinary Protein Binding Protein structure Respiratory syncytial virus Respiratory Syncytial Virus Infections - genetics Respiratory Syncytial Virus Infections - metabolism Respiratory Syncytial Virus Infections - virology Respiratory Syncytial Virus, Human - genetics Respiratory Syncytial Virus, Human - metabolism Ribonucleic acid RNA RNA polymerase RNA polymerase II Science Science (multidisciplinary) Structural analysis Transcription factors Transcription, Genetic Viral infections Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viruses
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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