Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment permissiveness when combined with a cancer vaccine

Background Growing awareness of the complexity of carcinogenesis has made multimodal therapies for cancer increasingly compelling and relevant. In recent years, immunotherapy has gained acceptance as an active therapeutic approach to cancer treatment, even though cancer is widely considered an immun...

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Vydáno v:	Journal of translational medicine Ročník 12; číslo 1; s. 294
Hlavní autoři:	Kwilas, Anna R, Ardiani, Andressa, Donahue, Renee N, Aftab, Dana T, Hodge, James W
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 13.11.2014 BioMed Central Ltd Springer Nature B.V
Témata:	Analysis Angiogenesis Anilides - pharmacology Anilides - therapeutic use Animals Antigens Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Cancer therapies Cancer Vaccines - immunology Care and treatment CEA (Oncology) Cell Line, Tumor Cell Proliferation - drug effects Clinical trials Combination strategies Combined Modality Therapy Confidence intervals Cytotoxicity Cytotoxicity, Immunologic - drug effects FDA approval Female Flow cytometry Genotype & phenotype Health aspects Immune response Immunization Immunotherapy Kinases Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology Lymphocytes Medical equipment and supplies industry Medical prognosis Medical test kit industry Medicine/Public Health Metastasis Mice, Inbred C57BL Mice, Transgenic Neoplasms - blood supply Neoplasms - drug therapy Neoplasms - immunology Neoplasms - pathology Phenotype Prostate cancer Pyridines - pharmacology Pyridines - therapeutic use Rodents Small Molecule Libraries - pharmacology Small Molecule Libraries - therapeutic use Software Studies T cells T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor Microenvironment - drug effects Tumors Tyrosine United States Cabozantinib Cancer vaccine Immunogenic modulation Combination therapy Immunotherapy Immune subset conditioning
ISSN:	1479-5876, 1479-5876
On-line přístup:	Získat plný text
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