A Clinical Trial of a Whole-Virus H5N1 Vaccine Derived from Cell Culture

There is a need for a vaccine against avian influenza (H5N1). In this initial study, the administration of two doses of a whole-virus H5N1 vaccine derived from Vero cell culture was shown to induce neutralizing-antibody responses to clades 1, 2, and 3 of H5N1 virus strains. The administration of two...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 358; no. 24; pp. 2573 - 2584
Main Authors:	Ehrlich, Hartmut J, Müller, Markus, Oh, Helen M.L, Tambyah, Paul A, Joukhadar, Christian, Montomoli, Emanuele, Fisher, Dale, Berezuk, Greg, Fritsch, Sandor, Löw-Baselli, Alexandra, Vartian, Nina, Bobrovsky, Roman, Pavlova, Borislava G, Pöllabauer, Eva Maria, Kistner, Otfried, Barrett, P. Noel
Format:	Journal Article
Language:	English
Published:	Boston, MA Massachusetts Medical Society 12.06.2008
Subjects:	Adjuvants, Immunologic - administration & dosage Adult Animals Antibodies, Viral - blood Avian flu Biological and medical sciences Cercopithecus aethiops Cross Reactions Female General aspects Humans Immunization Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Injections, Intramuscular - adverse effects Male Medical sciences Neutralization Tests Pandemics Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Vaccines Vero Cells Medicine Prevention Virus Influenzavirus A(H5N1) Cell culture Immunoprophylaxis Clinical trial Vaccine
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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