A Clinical Trial of a Whole-Virus H5N1 Vaccine Derived from Cell Culture

There is a need for a vaccine against avian influenza (H5N1). In this initial study, the administration of two doses of a whole-virus H5N1 vaccine derived from Vero cell culture was shown to induce neutralizing-antibody responses to clades 1, 2, and 3 of H5N1 virus strains. The administration of two...

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Vydáno v:	The New England journal of medicine Ročník 358; číslo 24; s. 2573 - 2584
Hlavní autoři:	Ehrlich, Hartmut J, Müller, Markus, Oh, Helen M.L, Tambyah, Paul A, Joukhadar, Christian, Montomoli, Emanuele, Fisher, Dale, Berezuk, Greg, Fritsch, Sandor, Löw-Baselli, Alexandra, Vartian, Nina, Bobrovsky, Roman, Pavlova, Borislava G, Pöllabauer, Eva Maria, Kistner, Otfried, Barrett, P. Noel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Boston, MA Massachusetts Medical Society 12.06.2008
Témata:	Adjuvants, Immunologic - administration & dosage Adult Animals Antibodies, Viral - blood Avian flu Biological and medical sciences Cercopithecus aethiops Cross Reactions Female General aspects Humans Immunization Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Injections, Intramuscular - adverse effects Male Medical sciences Neutralization Tests Pandemics Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Vaccines Vero Cells Medicine Prevention Virus Influenzavirus A(H5N1) Cell culture Immunoprophylaxis Clinical trial Vaccine
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	There is a need for a vaccine against avian influenza (H5N1). In this initial study, the administration of two doses of a whole-virus H5N1 vaccine derived from Vero cell culture was shown to induce neutralizing-antibody responses to clades 1, 2, and 3 of H5N1 virus strains. The administration of two doses of a whole-virus H5N1 vaccine derived from Vero cell culture was shown to induce neutralizing-antibody responses to clades 1, 2, and 3 of H5N1 virus strains. The emergence of a new human influenza pandemic caused by an avian virus strain is possible. Vaccination against pandemic influenza is considered to be the most effective option to limit its spread. However, the conventional approaches to the manufacture of influenza vaccines have a number of disadvantages and raise concern about whether sufficient quantities of an effective vaccine can be made available early enough at the onset of a pandemic to have a major effect on public health. 1 In addition, clinical studies of conventional split-vaccine formulations without adjuvant have shown poor immunogenicity. 2 , 3 It has been suggested that whole-virus vaccines . . .
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Feature-3 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa073121