Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

Zi-Jiang Chen and Yongyong Shi report a genome-wide association study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They identified three susceptibility loci associated with this condition. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women....

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Veröffentlicht in:Nature genetics Jg. 43; H. 1; S. 55 - 59
Hauptverfasser: Chen, Zi-Jiang, Zhao, Han, He, Lin, Shi, Yuhua, Qin, Yingying, Shi, Yongyong, Li, Zhiqiang, You, Li, Zhao, Junli, Liu, Jiayin, Liang, Xiaoyan, Zhao, Xiaoming, Zhao, Junzhao, Sun, Yingpu, Zhang, Bo, Jiang, Hong, Zhao, Dongni, Bian, Yuehong, Gao, Xuan, Geng, Ling, Li, Yiran, Zhu, Dongyi, Sun, Xiuqin, Xu, Jin-e, Hao, Cuifang, Ren, Chun-e, Zhang, Yajie, Chen, Shiling, Zhang, Wei, Yang, Aijun, Yan, Junhao, Li, Yuan, Ma, Jinlong, Zhao, Yueran
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Nature Publishing Group US 01.01.2011
Nature Publishing Group
Schlagworte:
631/208/205/2138
631/208/727/2000
692/699/2743/1526/1744
Agriculture
Animal Genetics and Genomics
Asian Continental Ancestry Group
Biomedical and Life Sciences
Biomedicine
Body mass index
Cancer Research
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 2 - genetics
Chromosomes, Human, Pair 9 - genetics
Confidence intervals
Disease susceptibility
Female
Gene Function
Genetic aspects
Genetic Predisposition to Disease
Genetics
Genome, Human - genetics
Genome-Wide Association Study
Genotype
Human Genetics
Humans
Hypothyroidism
Insulin resistance
letter
Meta-Analysis as Topic
Metabolic disorders
Methods
Odds Ratio
Physiological aspects
Polycystic ovary syndrome
Polycystic Ovary Syndrome - genetics
Principal components analysis
Risk factors
Single nucleotide polymorphisms
Stein-Leventhal syndrome
Studies
China
ISSN:1061-4036, 1546-1718, 1546-1718
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Zusammenfassung:Zi-Jiang Chen and Yongyong Shi report a genome-wide association study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They identified three susceptibility loci associated with this condition. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P -value by meta-analysis P meta = 7.55 × 10 −21 , odds ratio (OR) 0.71); 2p21 (rs13429458, P meta = 1.73 × 10 −23 , OR 0.67); and 9q33.3 (rs2479106, P meta = 8.12 × 10 −19 , OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
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ISSN:1061-4036
1546-1718
1546-1718
DOI:10.1038/ng.732