Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

Zi-Jiang Chen and Yongyong Shi report a genome-wide association study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They identified three susceptibility loci associated with this condition. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women....

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Published in:	Nature genetics Vol. 43; no. 1; pp. 55 - 59
Main Authors:	Chen, Zi-Jiang, Zhao, Han, He, Lin, Shi, Yuhua, Qin, Yingying, Shi, Yongyong, Li, Zhiqiang, You, Li, Zhao, Junli, Liu, Jiayin, Liang, Xiaoyan, Zhao, Xiaoming, Zhao, Junzhao, Sun, Yingpu, Zhang, Bo, Jiang, Hong, Zhao, Dongni, Bian, Yuehong, Gao, Xuan, Geng, Ling, Li, Yiran, Zhu, Dongyi, Sun, Xiuqin, Xu, Jin-e, Hao, Cuifang, Ren, Chun-e, Zhang, Yajie, Chen, Shiling, Zhang, Wei, Yang, Aijun, Yan, Junhao, Li, Yuan, Ma, Jinlong, Zhao, Yueran
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.01.2011 Nature Publishing Group
Subjects:	631/208/205/2138 631/208/727/2000 692/699/2743/1526/1744 Agriculture Animal Genetics and Genomics Asian Continental Ancestry Group Biomedical and Life Sciences Biomedicine Body mass index Cancer Research Chromosome Mapping Chromosomes Chromosomes, Human, Pair 2 - genetics Chromosomes, Human, Pair 9 - genetics Confidence intervals Disease susceptibility Female Gene Function Genetic aspects Genetic Predisposition to Disease Genetics Genome, Human - genetics Genome-Wide Association Study Genotype Human Genetics Humans Hypothyroidism Insulin resistance letter Meta-Analysis as Topic Metabolic disorders Methods Odds Ratio Physiological aspects Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Principal components analysis Risk factors Single nucleotide polymorphisms Stein-Leventhal syndrome Studies China
ISSN:	1061-4036, 1546-1718, 1546-1718
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Abstract	Zi-Jiang Chen and Yongyong Shi report a genome-wide association study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They identified three susceptibility loci associated with this condition. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P -value by meta-analysis P meta = 7.55 × 10 −21 , odds ratio (OR) 0.71); 2p21 (rs13429458, P meta = 1.73 × 10 −23 , OR 0.67); and 9q33.3 (rs2479106, P meta = 8.12 × 10 −19 , OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
AbstractList	Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P^sub meta^ = 7.55 × 10^sup -21^, odds ratio (OR) 0.71); 2p21 (rs13429458, P^sub meta^ = 1.73 × 10^sup -23^, OR 0.67); and 9q33.3 (rs2479106, P^sub meta^ = 8.12 × 10^sup -19^, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. [PUBLICATION ABSTRACT] Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P sub(meta) = 7.55 10 super(-21), odds ratio (OR) 0.71); 2p21 (rs13429458, P sub(meta) = 1.73 10 super(-23), OR 0.67); and 9q33.3 (rs2479106, P sub(meta) = 8.12 10 super(-19), OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. Zi-Jiang Chen and Yongyong Shi report a genome-wide association study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They identified three susceptibility loci associated with this condition. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P -value by meta-analysis P meta = 7.55 × 10 −21 , odds ratio (OR) 0.71); 2p21 (rs13429458, P meta = 1.73 × 10 −23 , OR 0.67); and 9q33.3 (rs2479106, P meta = 8.12 × 10 −19 , OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P(meta) = 7.55 × 10⁻²¹, odds ratio (OR) 0.71); 2p21 (rs13429458, P(meta) = 1.73 × 10⁻²³, OR 0.67); and 9q33.3 (rs2479106, P(meta) = 8.12 × 10⁻¹⁹, OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended. Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rsl 3405728; combined P-value by meta-analysis [P.sub.meta] = 7.55 x [10.sup.-21], odds ratio (OR) 0.71); 2p21 (rs13429458, [P.sub.meta] = 1.73 x [10.sup.-23], OR 0.67); and 9q33.3 (rs2479106, [P.sub.meta] = 8.12 x [10.sup.-19], OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
Audience	Academic
Author	Zhao, Xiaoming Ma, Jinlong Ren, Chun-e Qin, Yingying Chen, Zi-Jiang Li, Yiran Yang, Aijun Shi, Yongyong Zhao, Junzhao Gao, Xuan Zhao, Yueran Bian, Yuehong He, Lin Zhang, Bo Chen, Shiling Li, Zhiqiang Zhu, Dongyi Hao, Cuifang Zhang, Wei You, Li Jiang, Hong Liu, Jiayin Zhang, Yajie Liang, Xiaoyan Zhao, Han Yan, Junhao Sun, Xiuqin Li, Yuan Shi, Yuhua Zhao, Junli Xu, Jin-e Geng, Ling Sun, Yingpu Zhao, Dongni
Author_xml	– sequence: 1 givenname: Zi-Jiang surname: Chen fullname: Chen, Zi-Jiang email: zjchen59@yahoo.com organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 2 givenname: Han surname: Zhao fullname: Zhao, Han organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 3 givenname: Lin surname: He fullname: He, Lin organization: Institutes of Biomedical Sciences, Fudan University, Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences – sequence: 4 givenname: Yuhua surname: Shi fullname: Shi, Yuhua organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 5 givenname: Yingying surname: Qin fullname: Qin, Yingying organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 6 givenname: Yongyong surname: Shi fullname: Shi, Yongyong email: shiyongyong@gmail.com organization: Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University – sequence: 7 givenname: Zhiqiang surname: Li fullname: Li, Zhiqiang organization: Bio-X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University – sequence: 8 givenname: Li surname: You fullname: You, Li organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 9 givenname: Junli surname: Zhao fullname: Zhao, Junli organization: Affiliated Hospital of Ningxia Medical University – sequence: 10 givenname: Jiayin surname: Liu fullname: Liu, Jiayin organization: The First Affiliated Hospital with Nanjing Medical University – sequence: 11 givenname: Xiaoyan surname: Liang fullname: Liang, Xiaoyan organization: The Sixth Affiliated Hospital of Sun Yat-sen University – sequence: 12 givenname: Xiaoming surname: Zhao fullname: Zhao, Xiaoming organization: Renji Hospital Affiliated to Shanghai Jiaotong University – sequence: 13 givenname: Junzhao surname: Zhao fullname: Zhao, Junzhao organization: The First Affiliated Hospital of Wenzhou Medical College – sequence: 14 givenname: Yingpu surname: Sun fullname: Sun, Yingpu organization: The First Affiliated Hospital of Zhengzhou University – sequence: 15 givenname: Bo surname: Zhang fullname: Zhang, Bo organization: Maternal and Child Health Hospital in Guangxi – sequence: 16 givenname: Hong surname: Jiang fullname: Jiang, Hong organization: 105th Hospital of People's Liberation Army – sequence: 17 givenname: Dongni surname: Zhao fullname: Zhao, Dongni organization: Shengjing Hospital of China Medical University – sequence: 18 givenname: Yuehong surname: Bian fullname: Bian, Yuehong organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 19 givenname: Xuan surname: Gao fullname: Gao, Xuan organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 20 givenname: Ling surname: Geng fullname: Geng, Ling organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 21 givenname: Yiran surname: Li fullname: Li, Yiran organization: Qingdao Women & Children Medical Healthcare Center, Affiliated Hospital of Weifang Medical College – sequence: 22 givenname: Dongyi surname: Zhu fullname: Zhu, Dongyi organization: Linyi People's Hospital – sequence: 23 givenname: Xiuqin surname: Sun fullname: Sun, Xiuqin organization: Shandong Jingning First People's Hospital – sequence: 24 givenname: Jin-e surname: Xu fullname: Xu, Jin-e organization: The Affiliated Hospital of Medical College Qingdao University – sequence: 25 givenname: Cuifang surname: Hao fullname: Hao, Cuifang organization: Yantai Yuhuangding Hospital – sequence: 26 givenname: Chun-e surname: Ren fullname: Ren, Chun-e organization: Affiliated Hospital of Weifang Medical College – sequence: 27 givenname: Yajie surname: Zhang fullname: Zhang, Yajie organization: Jinan Health Institute of Maternity and Infant – sequence: 28 givenname: Shiling surname: Chen fullname: Chen, Shiling organization: Nanfang Hospital – sequence: 29 givenname: Wei surname: Zhang fullname: Zhang, Wei organization: Obstetrics & Gynecology Hospital of Fudan University – sequence: 30 givenname: Aijun surname: Yang fullname: Yang, Aijun organization: Affiliated Hospital of Jining Medical College – sequence: 31 givenname: Junhao surname: Yan fullname: Yan, Junhao organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 32 givenname: Yuan surname: Li fullname: Li, Yuan organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 33 givenname: Jinlong surname: Ma fullname: Ma, Jinlong organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China – sequence: 34 givenname: Yueran surname: Zhao fullname: Zhao, Yueran organization: Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, China
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/21151128$$D View this record in MEDLINE/PubMed
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References	XuSGenomic dissection of population substructure of Han Chinese and its implication in association studiesAm. J. Hum. Genet.200985762774 DrieschnerNEvidence for a 3p25 breakpoint hot spot region in thyroid tumors of follicular originThyroid20061610911096 ShiYGaoXSunXZhangPChenZClinical and metabolic characteristics of polycystic ovary syndrome without polycystic ovary: a pilot study on Chinese womenFertil. Steril.20089011391143 ThomasGCapillary and microelectrophoretic separations of ligase detection reaction products produced from low-abundant point mutations in genomic DNAElectrophoresis20042516681677 CarminaECardiovascular risk and events in polycystic ovary syndromeClimacteric200912suppl. 12225 FerrimanDGallweyJDClinical assessment of body hair growth in womenJ. Clin. Endocrinol. Metab.19612114401447 MantelNHaenszelWStatistical aspects of the analysis of data from retrospective studiesJ. Natl. Cancer Inst.195922719748 KornJMIntegrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVsNat. Genet.20084012531260 DuJTwo FSHR variants, haplotypes and meta-analysis in Chinese women with premature ovarian failure and polycystic ovary syndromeMol. Genet. Metab.2010100292295 PetukhovaLGenome-wide association study in alopecia areata implicates both innate and adaptive immunityNature2010466113117 RadziukJInsulin sensitivity and its measurement: structural commonalities among the methodsJ. Clin. Endocrinol. Metab.20008544264433 GoodarziMOAzzizRDiagnosis, epidemiology, and genetics of the polycystic ovary syndromeBest Pract. Res. Clin. Endocrinol. Metab.200620193205 SaxenaRGenome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsScience200731613311336 YiPPCR/LDR/capillary electrophoresis for detection of single-nucleotide differences between fetal and maternal DNA in maternal plasmaPrenat. Diagn.200929217222 ChenZJCorrelation between single nucleotide polymorphism of insulin receptor gene with polycystic ovary syndromeZhonghua Fu Chan Ke Za Zhi200439582585 Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome. Fertil. Steril.81, 19–25 (2004). EhrmannDABarnesRBRosenfieldRLCavaghanMKImperialJPrevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndromeDiabetes Care199922141146 Espinós-GómezJJCorcoyRCalafJPrevalence and predictors of abnormal glucose metabolism in Mediterranean women with polycystic ovary syndromeGynecol. Endocrinol.200925199204 HuCPPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese populationPLoS ONE20094e7643 ShiYAnalysis of clinical characteristics in large-scale Chinese women with polycystic ovary syndromeNeuroendocrinol. Lett.200728807810 CarlsonCSEberleMAKruglyakLNickersonDAMapping complex disease loci in whole-genome association studiesNature2004429446452 ToledoSPAAn inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46, XX femaleJ. Clin. Endocrinol. Metab.19968138503854 KulshreshthaBInsulin response to oral glucose in healthy, lean young women and patients with polycystic ovary syndromeGynecol. Endocrinol.200824637643 Del VillarKMillerCADown-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer?s disease brain and hippocampal neuronsProc. Natl. Acad. Sci. USA200410142104215 WangYWuXCaoYYiLChenJA microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndromeFertil. Steril.200686223226 HuangMInvolvement of ALF in human spermatogenesis and male infertilityInt. J. Mol. Med.200617599604 Olszanecka-GlinianowiczMIs the polycystic ovary syndrome associated with chronic inflammation per se?Eur. J. Obstet. Gynecol. Reprod. Biol.2007133197202 ShiYYHeLSHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism lociCell Res.2005159798 LatronicoACA homozygous microdeletion in helix 7 of the luteinizing hormone receptor associated with familial testicular and ovarian resistance is due to both decreased cell surface expression and impaired effector activation by the cell surface receptorMol. Endocrinol.199812442450 TongYLiaoWXRoyACNgSCAbsence of mutations in the coding regions of follicle-stimulating hormone receptor gene in Singapore Chinese women with premature ovarian failure and polycystic ovary syndromeHorm. Metab. 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Reprod.20092420142022 ZegginiEMeta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesNat. Genet.200840638645 LatronicoACLinsTSBritoVNArnholdIJMendoncaBBThe effect of distinct activating mutations of the luteinizing hormone receptor gene on the pituitary-gonadal axis in both sexesClin. Endocrinol.200053609613 JC Barrett (BFng732_CR37) 2005; 21 JM Korn (BFng732_CR32) 2008; 40 Y Wang (BFng732_CR11) 2006; 86 AC Latronico (BFng732_CR18) 1998; 12 S Sudo (BFng732_CR10) 2002; 8 M Huang (BFng732_CR17) 2006; 17 C Hu (BFng732_CR26) 2009; 4 YY Shi (BFng732_CR35) 2005; 15 S Xu (BFng732_CR15) 2009; 85 AC Latronico (BFng732_CR20) 2000; 53 J Du (BFng732_CR23) 2010; 100 ZJ Chen (BFng732_CR12) 2004; 39 Y Shi (BFng732_CR9) 2007; 28 CS Carlson (BFng732_CR14) 2004; 429 B Kulshreshtha (BFng732_CR8) 2008; 24 G Thomas (BFng732_CR33) 2004; 25 E Kandaraki (BFng732_CR5) 2009; 53 N Drieschner (BFng732_CR24) 2006; 16 O Valkenburg (BFng732_CR21) 2009; 24 K Del Villar (BFng732_CR27) 2004; 101 E Carmina (BFng732_CR4) 2009; 12 L Petukhova (BFng732_CR36) 2010; 466 R Saxena (BFng732_CR38) 2007; 316 JJ Espinós-Gómez (BFng732_CR7) 2009; 25 J Radziuk (BFng732_CR31) 2000; 85 MO Goodarzi (BFng732_CR2) 2006; 20 DA Ehrmann (BFng732_CR3) 1999; 22 AL Price (BFng732_CR16) 2006; 38 BFng732_CR1 M Olszanecka-Glinianowicz (BFng732_CR28) 2007; 133 Y Shi (BFng732_CR30) 2008; 90 G Villuendas (BFng732_CR13) 2002; 87 N Mantel (BFng732_CR39) 1959; 22 P Yi (BFng732_CR34) 2009; 29 S Wild (BFng732_CR6) 2000; 3 SPA Toledo (BFng732_CR19) 1996; 81 D Ferriman (BFng732_CR29) 1961; 21 Y Tong (BFng732_CR22) 2001; 33 E Zeggini (BFng732_CR25) 2008; 40 19177453 - Prenat Diagn. 2009 Mar;29(3):217-22 19944404 - Am J Hum Genet. 2009 Dec;85(6):762-74 19811236 - Climacteric. 2009;12 Suppl 1:22-5 16772151 - Best Pract Res Clin Endocrinol Metab. 2006 Jun;20(2):193-205 15498182 - Zhonghua Fu Chan Ke Za Zhi. 2004 Sep;39(9):582-5 11134088 - J Clin Endocrinol Metab. 2000 Dec;85(12):4426-33 20399696 - Mol Genet Metab. 2010 Jul;100(3):292-5 18372903 - Nat Genet. 2008 May;40(5):638-45 11889177 - J Clin Endocrinol Metab. 2002 Mar;87(3):1134-41 20596022 - Nature. 2010 Jul 1;466(7302):113-7 10333916 - Diabetes Care. 1999 Jan;22(1):141-6 19031221 - Gynecol Endocrinol. 2008 Nov;24(11):637-43 19466215 - Arq Bras Endocrinol Metabol. 2009 Mar;53(2):227-37 8923827 - J Clin Endocrinol Metab. 1996 Nov;81(11):3850-4 11844363 - Hum Fertil (Camb). 2000;3(2):101-105 9514160 - Mol Endocrinol. 1998 Mar;12(3):442-50 15007167 - Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4210-5 12356937 - Mol Hum Reprod. 2002 Oct;8(10):893-9 17889857 - Fertil Steril. 2008 Oct;90(4):1139-43 17224231 - Eur J Obstet Gynecol Reprod Biol. 2007 Aug;133(2):197-202 11106922 - Clin Endocrinol (Oxf). 2000 Nov;53(5):609-13 13655060 - J Natl Cancer Inst. 1959 Apr;22(4):719-48 11383926 - Horm Metab Res. 2001 Apr;33(4):221-6 16525715 - Int J Mol Med. 2006 Apr;17(4):599-604 15740637 - Cell Res. 2005 Feb;15(2):97-8 19862325 - PLoS One. 2009 Oct 28;4(10 ):e7643 18063948 - Neuro Endocrinol Lett. 2007 Dec;28(6):807-10 14711538 - Fertil Steril. 2004 Jan;81(1):19-25 19347711 - Gynecol Endocrinol. 2009 Mar;25(3):199-204 16764871 - Fertil Steril. 2006 Jul;86(1):223-6 17463246 - Science. 2007 Jun 1;316(5829):1331-6 17123335 - Thyroid. 2006 Nov;16(11):1091-6 18776909 - Nat Genet. 2008 Oct;40(10):1253-60 16862161 - Nat Genet. 2006 Aug;38(8):904-9 15297300 - Bioinformatics. 2005 Jan 15;21(2):263-5 15164069 - Nature. 2004 May 27;429(6990):446-52 13892577 - J Clin Endocrinol Metab. 1961 Nov;21:1440-7 19403562 - Hum Reprod. 2009 Aug;24(8):2014-22 15188256 - Electrophoresis. 2004 Jun;25(10-11):1668-77
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Metabol.200953227237 – reference: ThomasGCapillary and microelectrophoretic separations of ligase detection reaction products produced from low-abundant point mutations in genomic DNAElectrophoresis20042516681677 – reference: SudoSGenetic and functional analyses of polymorphisms in the human FSH receptor geneMol. Hum. Reprod.20028893899 – reference: VilluendasGSan MillánJLSanchoJEscobar-MorrealeHFThe -597 G→A and -174 G→C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenismJ. Clin. Endocrinol. Metab.20028711341141 – reference: ShiYGaoXSunXZhangPChenZClinical and metabolic characteristics of polycystic ovary syndrome without polycystic ovary: a pilot study on Chinese womenFertil. Steril.20089011391143 – reference: FerrimanDGallweyJDClinical assessment of body hair growth in womenJ. Clin. Endocrinol. Metab.19612114401447 – reference: Olszanecka-GlinianowiczMIs the polycystic ovary syndrome associated with chronic inflammation per se?Eur. J. Obstet. 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Diagn.200929217222 – reference: PetukhovaLGenome-wide association study in alopecia areata implicates both innate and adaptive immunityNature2010466113117 – reference: CarlsonCSEberleMAKruglyakLNickersonDAMapping complex disease loci in whole-genome association studiesNature2004429446452 – reference: ToledoSPAAn inactivating mutation of the luteinizing hormone receptor causes amenorrhea in a 46, XX femaleJ. Clin. Endocrinol. Metab.19968138503854 – reference: KulshreshthaBInsulin response to oral glucose in healthy, lean young women and patients with polycystic ovary syndromeGynecol. Endocrinol.200824637643 – reference: TongYLiaoWXRoyACNgSCAbsence of mutations in the coding regions of follicle-stimulating hormone receptor gene in Singapore Chinese women with premature ovarian failure and polycystic ovary syndromeHorm. Metab. 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Snippet	Zi-Jiang Chen and Yongyong Shi report a genome-wide association study for polycystic ovary syndrome, a common metabolic and endocrine disorder in women. They... Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of...
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SubjectTerms	631/208/205/2138 631/208/727/2000 692/699/2743/1526/1744 Agriculture Animal Genetics and Genomics Asian Continental Ancestry Group Biomedical and Life Sciences Biomedicine Body mass index Cancer Research Chromosome Mapping Chromosomes Chromosomes, Human, Pair 2 - genetics Chromosomes, Human, Pair 9 - genetics Confidence intervals Disease susceptibility Female Gene Function Genetic aspects Genetic Predisposition to Disease Genetics Genome, Human - genetics Genome-Wide Association Study Genotype Human Genetics Humans Hypothyroidism Insulin resistance letter Meta-Analysis as Topic Metabolic disorders Methods Odds Ratio Physiological aspects Polycystic ovary syndrome Polycystic Ovary Syndrome - genetics Principal components analysis Risk factors Single nucleotide polymorphisms Stein-Leventhal syndrome Studies
Title	Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
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