Efficient CRISPR-Cas13d-Based Antiviral Strategy to Combat SARS-CoV-2

The current SARS-CoV-2 pandemic forms a major global health burden. Although protective vaccines are available, concerns remain as new virus variants continue to appear. CRISPR-based gene-editing approaches offer an attractive therapeutic strategy as the CRISPR-RNA (crRNA) can be adjusted rapidly to...

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Bibliographic Details
Published in:	Viruses Vol. 15; no. 3; p. 686
Main Authors:	Hussein, Mouraya, Andrade dos Ramos, Zaria, Vink, Monique A., Kroon, Pascal, Yu, Zhenghao, Enjuanes, Luis, Zuñiga, Sonia, Berkhout, Ben, Herrera-Carrillo, Elena
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 06.03.2023 MDPI
Subjects:	Analysis Antiviral activity Antiviral agents Antiviral Agents - pharmacology Antiviral drugs antiviral properties Artificial chromosomes Coronaviruses COVID-19 COVID-19 vaccines CRISPR CRISPR-Cas13d Design Dosage and administration FDA approval gene editing Gene Editing - methods Genetic variation Genome editing Genomes Genomics Humans Nucleotide sequence pandemic Pandemics Public health replicon Ribonucleic acid RNA RNA polymerase RNA, Viral - genetics RNA, Viral - metabolism SARS-CoV-2 - genetics SARS-CoV-2 - metabolism SARS-CoV-2 genome Severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome-related coronavirus therapeutics viral genome viruses Zoonoses Netherlands COVID-19 CRISPR-Cas13d RNA SARS-CoV-2 genome
ISSN:	1999-4915, 1999-4915
Online Access:	Get full text
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