Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides

Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analys...

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Vydané v:	Translational psychiatry Ročník 8; číslo 1; s. 224 - 13
Hlavní autori:	Zhou, Yi, Lutz, Pierre-Eric, Wang, Yu Chang, Ragoussis, Jiannis, Turecki, Gustavo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 18.10.2018 Nature Publishing Group Nature Pub. Group
Predmet:	38/39 38/47 38/77 38/91 631/378/2584/2585 692/699/476/1414 Behavioral Sciences Biological Psychology Cell adhesion & migration Cognitive science Depressive Disorder, Major - metabolism Female Gene Expression Regulation Gyrus Cinguli - metabolism Humans Male Medicine Medicine & Public Health Neuroscience Neurosciences Pharmacotherapy Proteins Psychiatry RNA, Long Noncoding - metabolism Sequence Analysis, RNA Suicide Suicides & suicide attempts Transcriptome
ISSN:	2158-3188, 2158-3188
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Abstract	Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs (FDR < 0.1) as well as their differentially expressed overlapping and antisense protein-coding genes. Several of these overlapping or antisense genes were associated with interferon signaling, which is a component of the innate immune response. Using WGCNA, we identified modules of highly co-expressed genes associated with depression and suicide and found protein-coding genes highly connected to differentially expressed lncRNAs within these modules. These protein-coding genes were located distal to their associated lncRNAs and were found to be part of several GO terms enriched in the significant modules, which include: cytoskeleton organization, plasma membrane, cell adhesion, nucleus, DNA-binding, and regulation of dendrite development and morphology. Altogether, we report that lncRNAs are differentially expressed in the brains of depressed individuals who died by suicide and may represent regulators of important molecular functions and biological processes.
AbstractList	Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs (FDR < 0.1) as well as their differentially expressed overlapping and antisense protein-coding genes. Several of these overlapping or antisense genes were associated with interferon signaling, which is a component of the innate immune response. Using WGCNA, we identified modules of highly co-expressed genes associated with depression and suicide and found protein-coding genes highly connected to differentially expressed lncRNAs within these modules. These protein-coding genes were located distal to their associated lncRNAs and were found to be part of several GO terms enriched in the significant modules, which include: cytoskeleton organization, plasma membrane, cell adhesion, nucleus, DNA-binding, and regulation of dendrite development and morphology. Altogether, we report that lncRNAs are differentially expressed in the brains of depressed individuals who died by suicide and may represent regulators of important molecular functions and biological processes.Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs (FDR < 0.1) as well as their differentially expressed overlapping and antisense protein-coding genes. Several of these overlapping or antisense genes were associated with interferon signaling, which is a component of the innate immune response. Using WGCNA, we identified modules of highly co-expressed genes associated with depression and suicide and found protein-coding genes highly connected to differentially expressed lncRNAs within these modules. These protein-coding genes were located distal to their associated lncRNAs and were found to be part of several GO terms enriched in the significant modules, which include: cytoskeleton organization, plasma membrane, cell adhesion, nucleus, DNA-binding, and regulation of dendrite development and morphology. Altogether, we report that lncRNAs are differentially expressed in the brains of depressed individuals who died by suicide and may represent regulators of important molecular functions and biological processes. Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs (FDR < 0.1) as well as their differentially expressed overlapping and antisense protein-coding genes. Several of these overlapping or antisense genes were associated with interferon signaling, which is a component of the innate immune response. Using WGCNA, we identified modules of highly co-expressed genes associated with depression and suicide and found protein-coding genes highly connected to differentially expressed lncRNAs within these modules. These protein-coding genes were located distal to their associated lncRNAs and were found to be part of several GO terms enriched in the significant modules, which include: cytoskeleton organization, plasma membrane, cell adhesion, nucleus, DNA-binding, and regulation of dendrite development and morphology. Altogether, we report that lncRNAs are differentially expressed in the brains of depressed individuals who died by suicide and may represent regulators of important molecular functions and biological processes.
ArticleNumber	224
Author	Lutz, Pierre-Eric Wang, Yu Chang Zhou, Yi Ragoussis, Jiannis Turecki, Gustavo
Author_xml	– sequence: 1 givenname: Yi orcidid: 0000-0003-1301-7015 surname: Zhou fullname: Zhou, Yi organization: McGill Group for Suicide Studies, McGill University – sequence: 2 givenname: Pierre-Eric orcidid: 0000-0003-3383-1604 surname: Lutz fullname: Lutz, Pierre-Eric organization: McGill Group for Suicide Studies, McGill University, Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Fédération de Médecine Translationnelle de Strasbourg – sequence: 3 givenname: Yu Chang surname: Wang fullname: Wang, Yu Chang organization: McGill University and Génome Québec Innovation Centre – sequence: 4 givenname: Jiannis surname: Ragoussis fullname: Ragoussis, Jiannis organization: McGill University and Génome Québec Innovation Centre – sequence: 5 givenname: Gustavo orcidid: 0000-0003-4075-2736 surname: Turecki fullname: Turecki, Gustavo email: gustavo.turecki@mcgill.ca organization: McGill Group for Suicide Studies, McGill University
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Snippet	Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the...
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SubjectTerms	38/39 38/47 38/77 38/91 631/378/2584/2585 692/699/476/1414 Behavioral Sciences Biological Psychology Cell adhesion & migration Cognitive science Depressive Disorder, Major - metabolism Female Gene Expression Regulation Gyrus Cinguli - metabolism Humans Male Medicine Medicine & Public Health Neuroscience Neurosciences Pharmacotherapy Proteins Psychiatry RNA, Long Noncoding - metabolism Sequence Analysis, RNA Suicide Suicides & suicide attempts Transcriptome
Title	Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides
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