COMPASS and SWI/SNF complexes in development and disease

The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene expression programmes established by the Polycomb group of proteins and to promote and maintain an active state of gene expression. Recent st...

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Bibliographic Details
Published in:Nature reviews. Genetics Vol. 22; no. 1; pp. 38 - 58
Main Authors: Cenik, Bercin K, Shilatifard, Ali
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.01.2021
Subjects:
Animals
Chromatin - genetics
Chromatin Assembly and Disassembly
Chromatin remodeling
Chromosomal Proteins, Non-Histone - genetics
Chromosomal Proteins, Non-Histone - metabolism
Developmental disabilities
Drosophila - genetics
Drosophila - metabolism
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Epigenetics
Gene expression
Gene Expression Regulation, Developmental
Gene regulation
Growth and Development - genetics
Histone H3
Histone methyltransferase
Histone-Lysine N-Methyltransferase - genetics
Histone-Lysine N-Methyltransferase - metabolism
Humans
Lysine
Methyltransferase
Mice
Models, Molecular
Multiprotein Complexes
Neoplasms - genetics
Polycomb group proteins
Polycomb-Group Proteins - genetics
Polycomb-Group Proteins - metabolism
Proteins
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae Proteins - genetics
Saccharomyces cerevisiae Proteins - metabolism
ISSN:1471-0056, 1471-0064, 1471-0064
Online Access:Get full text
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Summary:The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene expression programmes established by the Polycomb group of proteins and to promote and maintain an active state of gene expression. Recent studies are providing new insights into how two crucial families of the TrxG - the COMPASS family of histone H3 lysine 4 methyltransferases and the SWI/SNF family of chromatin remodelling complexes - regulate gene expression and developmental programmes, and how misregulation of their activities through genetic abnormalities leads to pathologies such as developmental disorders and malignancies.
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ISSN:1471-0056
1471-0064
1471-0064
DOI:10.1038/s41576-020-0278-0