COMPASS and SWI/SNF complexes in development and disease

The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene expression programmes established by the Polycomb group of proteins and to promote and maintain an active state of gene expression. Recent st...

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Vydáno v:	Nature reviews. Genetics Ročník 22; číslo 1; s. 38 - 58
Hlavní autoři:	Cenik, Bercin K, Shilatifard, Ali
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Nature Publishing Group 01.01.2021
Témata:	Animals Chromatin - genetics Chromatin Assembly and Disassembly Chromatin remodeling Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Developmental disabilities Drosophila - genetics Drosophila - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Epigenetics Gene expression Gene Expression Regulation, Developmental Gene regulation Growth and Development - genetics Histone H3 Histone methyltransferase Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Lysine Methyltransferase Mice Models, Molecular Multiprotein Complexes Neoplasms - genetics Polycomb group proteins Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Proteins Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism
ISSN:	1471-0056, 1471-0064, 1471-0064
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Shrnutí:	The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that form multiprotein complexes to counteract repressive developmental gene expression programmes established by the Polycomb group of proteins and to promote and maintain an active state of gene expression. Recent studies are providing new insights into how two crucial families of the TrxG - the COMPASS family of histone H3 lysine 4 methyltransferases and the SWI/SNF family of chromatin remodelling complexes - regulate gene expression and developmental programmes, and how misregulation of their activities through genetic abnormalities leads to pathologies such as developmental disorders and malignancies.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1471-0056 1471-0064 1471-0064
DOI:	10.1038/s41576-020-0278-0